VA-ECOM assisted percutaneous mechanical thrombectomy treatment high-risk pulmonary embolism.

Background: Percutaneous mechanical thrombectomy (PMT) is increasingly used in the treatment of intermediate and high-risk acute pulmonary embolism (PE), and the treatment of high-risk PE with the aid of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has also been reported. However, there are few reports of VA-ECOM-assisted PMT in the treatment of high-risk PE. The purpose of this study is to summarize the data of 11 patients with high-risk PE treated with VA-ECMO assisted PMT, and propose feasible treatment methods for such patients.

Hydrogel doped with sinomenine-CeO nanoparticles for sustained intra-articular therapy in knee osteoarthritis.

In this study, we developed an intra-articular injectable hydrogel drug depot (SMN-CeO@G) for sustained OA treatment. This hydrogel system, which carries sinomenine-loaded cerium dioxide nanoparticles (SMN-CeO), enhances anti-inflammatory and anti-apoptotic effects within the joint cavity. SMN-CeO@G features a three-dimensional network structure with an approximate pore size of 10 μm, stably encapsulating SMN-CeO nanoparticles (∼75 nm).

Semantic aware enhanced event causality identification.

Event Causality Identification (ECI) aims to predict causal relations between events in a text. Existing research primarily focuses on leveraging external knowledge such as knowledge graphs and dependency trees to construct explicit structured features to enrich event representations. However, this approach underestimates the semantic features of the original input sentences and performs poorly in capturing implicit causal relations.

Understanding the mechanism of saccharides type and concentration affecting texture of freeze-dried pectin-CMC cryogels through experiment and molecular dynamic simulation.

Saccharides are the dominant factor shaping the texture of freeze-dried products. This study investigated the impact of various molecular-weight saccharides at different concentrations on the physical properties and intermolecular interactions of pectin-CMC cryogels by experiment and molecular dynamic (MD) simulations. Results showed that the increased shrinkage of cryogels and enhanced molecular interactions between saccharides and pectin-CMC were mechanisms that enhanced the hardness of cryogels.

Vacuum suction catheter semi-rigid ureteroscopic laser lithotripsy for impacted upper ureteral stones: randomised controlled trial.

Purpose: To evaluate the effectiveness and safety of an upgraded integrated vacuum suction catheter in semi-rigid ureteroscopic laser lithotripsy (VC-URSL) compared to traditional methods for treating impacted upper ureteral stones.

Patients And Methods: This prospective, randomized controlled trial was conducted from September 2022 to March 2024 at a single center, enrolling 95 patients aged 18 to 70 years with a single radiopaque impacted upper ureteral stone. Participants were randomized into two groups: the VC-URSL group used an integrated vacuum suction catheter featuring a stainless steel stabilizing tube and a narrowed distal end to prevent obstruction, while the T-URSL group underwent standard ureteroscopic lithotripsy without vacuum assistance.

Adaptive discrete-time neural prescribed performance control: A safe control approach.

Most existing results on prescribed performance control (PPC), subject to input saturation and initial condition limitations, focus on continuous-time nonlinear systems. This article, as regards discrete-time nonlinear systems, is dedicated to constructing a novel adaptive switching control strategy to circumvent the singular problem when the PPC undergoes input saturation, while the initial conditions of the system can be released under the framework of PPC. The main design steps and characteristics include: (1) By devising a new discrete-time global finite-time performance function (DTGFTPF), the constructed performance boundary is shown to survive insensitive to arbitrary initial values, which present in the system; (2) A discrete-time adaptive finite-time prescribed performance controller (DTAFPPC) and a discrete-time adaptive backstepping controller (DTABC) are constructed, simultaneously.

Induced Ferroptosis to Inhibit Glioma Cells and was Associated with Increased Oxidative Stress.

Background: Glioma, a malignant brain tumour, poses a significant threat to human life and well-being. Identifying new treatment targets is crucial. This study aimed to explore the impact of (BRCA1 interacting helicase 1) on glioma cell ferroptosis and its underlying mechanisms.

Accurate and Fast Prediction of Intrinsic Disorder Using flDPnn.

Intrinsically disordered proteins (IDPs) that include one or more intrinsically disordered regions (IDRs) are abundant across all domains of life and viruses and play numerous functional roles in various cellular processes. Due to a relatively low throughput and high cost of experimental techniques for identifying IDRs, there is a growing need for fast and accurate computational algorithms that accurately predict IDRs/IDPs from protein sequences. We describe one of the leading disorder predictors, flDPnn.

Saffron improves the efficacy of immunotherapy for colorectal cancer through the IL-17 signaling pathway.

Ethnopharmacological Relevance: Saffron is one of the traditional medicinal herbs, which contains various active ingredients, such as safranal, crocin, saffron acid, etc. It has anti-inflammatory, antioxidant, and anti-cancer properties, and is widely used in clinical practice. The anti-cancer efficacy of saffron has been previously confirmed, but its anti-cancer mechanism in colorectal cancer remains unclear.

Switching CO Electroreduction Pathways between Ethylene and Ethanol via Tuning Microenvironment of the Coating on Copper Nanofibers.

Engineering the microenvironment of electrode surface is one of the effective means to tune the reaction pathways in CORR. In this work, we prepared copper nanofibers with conductive polypyrrole coating by polymerization of pyrrole using polyvinyl pyrrolidone (PVP) as template. As a result, the obtained copper nanofibers Cu/CuO/SHNC, exhibited a superhydrophobic surface, which demonstrated very high selectivity for ethanol with a Faraday efficiency (FE) of 66.

Comorbidity of white matter lesions in parkinson's disease: a study on risk factors and phenotypic differences.

Background: Comorbidity of white matter lesions (WMLs) in idiopathic Parkinson's disease (PD) is becoming increasingly common.

Objective: To analyze the risk factors and phenotypic differences for the occurrence and severity of WMLs in patients with PD.

Methods: A total of 123 PD patients underwent clinical, laboratory, and magnetic resonance imaging (MRI) evaluations.

Zero-Intrarenal Pressure Percutaneous Nephrolithotomy for One-Stage Treatment of Non-Acute Infectious Calculous Pyonephrosis: A Strategy to Avert Sepsis.

To evaluate the efficacy and safety of a novel zero-intrarenal pressure (IRP) percutaneous nephrolithotomy (PCNL) technique for one-stage treatment of non-acute infectious calculous pyonephrosis. This retrospective study analyzed 12 patients (4 males, 8 females; mean age 56.4 years) who underwent zero-IRP PCNL.

Higher molecular weight pectin inhibits ice crystal growth and its effect on the microstructural and physical properties of pectin cryogels.

Understanding the formation of ice crystals is essential for tailoring the microstructure and physical properties of cryogels. This study investigated the effects and mechanisms of pectin molecular weight (Mw) on impacting ice crystal formation. Pectin fractions various Mw (10.

Recent advances in small-angle scattering techniques for MOF colloidal materials.

This paper reviews the recent progress of small angle scattering (SAS) techniques, mainly including X-ray small angle scattering technique (SAXS) and neutron small angle scattering (SANS) technique, in the study of metal-organic framework (MOF) colloidal materials (CMOFs). First, we introduce the application research of SAXS technique in pristine MOFs materials, and review the studies on synthesis mechanism of MOF materials, the pore structures and fractal characteristics, as well as the spatial distribution and morphological evolution of foreign molecules in MOF composites and MOF-derived materials. Then, the applications of SANS technique in MOFs are summarized, with emphasis on SANS data processing method, structure modeling and quantitative structural information extraction.

A step towards 6D WAXD tensor tomography.

X-ray scattering/diffraction tensor tomography techniques are promising methods to acquire the 3D texture information of heterogeneous biological tissues at micrometre resolution. However, the methods suffer from a long overall acquisition time due to multi-dimensional scanning across real and reciprocal space. Here, a new approach is introduced to obtain 3D reciprocal information of each illuminated scanning volume using mathematic modeling, which is equivalent to a physical scanning procedure for collecting the full reciprocal information required for voxel reconstruction.

Alien emergent aquatic plants develop better ciprofloxacin tolerance and metabolic capacity than one native submerged species.

Antibiotic pollution and biological invasion pose significant risks to freshwater biodiversity and ecosystem health. However, few studies have compared the ecological adaptability and ciprofloxacin (CIPR) degradation potential between alien and native macrophytes. We examined growth, physiological response, and CIPR accumulation, translocation and metabolic abilities of two alien plants (Eichhornia crassipes and Myriophyllum aquaticum) and one native submerged species (Vallisneria natans) exposed to CIPR at 0, 1 and 10 mg/L.

Assessment of Disordered Linker Predictions in the CAID2 Experiment.

Disordered linkers (DLs) are intrinsically disordered regions that facilitate movement between adjacent functional regions/domains, contributing to many key cellular functions. The recently completed second Critical Assessments of protein Intrinsic Disorder prediction (CAID2) experiment evaluated DL predictions by considering a rather narrow scenario when predicting 40 proteins that are already known to have DLs. We expand this evaluation by using a much larger set of nearly 350 test proteins from CAID2 and by investigating three distinct scenarios: (1) prediction residues in DLs vs.

Alkyl sulfonate surfactant mediates electroreduction of carbon dioxide to ethylene or ethanol over hydroxide-derived copper catalysts.

For CO electroreduction (COER) to C compounds, it is generally accepted that the formation of ethylene and ethanol shares the same intermediate, *HCCOH. The majority of studies have achieved high faradaic efficiency (FE) towards ethylene, but faced challenges to get high ethanol FE. Herein, we present an alkyl sulfonate surfactant (, sodium dodecyl sulfonate, SDS) mediated COER to a C product over an generated Cu catalyst (Cu@SDS) from SDS-modified Cu(OH).

A Study on the Nanostructural Evolution of Bi/C Anode Materials during Their First Charge/Discharge Processes.

As a candidate anode material for Li-ion batteries, Bi-based materials have attracted extensive attention from researchers due to their high specific capacity, environmental friendliness, and simple synthesis methods. However, Bi-based anode materials are prone to causing large volume changes during charging and discharging processes, and the effect of these changes on lithium storage performance is still unclear. This work introduces that Bi/C nanocomposites are prepared by the Bi-based MOF precursor calcination method, and that the Bi/C nanocomposite maintains a high specific capacity (931.

Ecotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate on aquatic plant Vallisneria natans.

Perfluorinated compounds (PFCs) are persistent organic contaminants that are highly toxic to the environment and bioaccumulate, but their ecotoxic effects on aquatic plants remain unclear. In this study, the submerged plant Vallisneria natans was treated with short-term (7 days) and long-term (21 days) exposures to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) at concentrations of 0, 0.01, 0.

Clinical Efficacy Evaluation of a Novel Negative Pressure Ureteroscopic Lithotripsy for Ureteral Stones.

Objective: To evaluate the clinical efficacy of a novel negative pressure ureteroscopic lithotripsy (NP-URL) compared to standard ureteroscopic lithotripsy (S-URL) for treating ureteral stones.

Methods: A total of 284 patients diagnosed with ureteral stones and who underwent ureteroscopic lithotripsy between December 2020 and May 2022 at our hospital were included in the study. Among them, 146 cases underwent NP-URL and 138 cases underwent S-URL.

Forsythiaside A suppresses renal fibrosis and partial epithelial-mesenchymal transition by targeting THBS1 through the PI3K/AKT signaling pathway.

Renal fibrosis is a key feature of chronic kidney disease (CKD) progression, whereas no proven effective anti-fibrotic treatments. Forsythiaside A (FTA), derived from Forsythia suspense, has been found to possess nephroprotective properties. However, there is limited research on its anti-fibrotic effects, and its mechanism of action remains unknown.

Tailoring microstructure and mechanical properties of pectin cryogels by modulate intensity of ionic interconnection.

Porous morphology and mechanical properties determine the applications of cryogels. To understand the influence of the ionic network on the microstructure and mechanical properties of pectin cryogels, we prepared low-methoxyl pectin (LMP) cryogels with different Ca concentrations (measured as R-value, ranging from 0 to 2) through freeze-drying (FD). Results showed that the R-values appeared to be crucial parameters that impact the pore morphology and mechanical characteristics of cryogels.