Intercellular Ion-Gradient Piezoheterogated Biphasic Gel for Ultrahigh Iontronic Generation.

Piezoionic materials have attracted considerable attention for their ability to generate iontronic signals or power in response to stress stimuli. However, the limited intrinsic transport distinction between cations and anions within most ionic materials results in weakened iontronic power conversion efficiencies under stress fields. Here, we report a piezoheterogated biphasic gel for ultrahigh iontronic generation, characterized by high-internal microphase heterointerfaces that facilitate the distinct transport of various ion species.

Generation of a red-green-blue laser by stimulated Raman scattering of ethanol.

In this paper, we report an efficient red-green-blue (RGB) laser based on the stimulated Raman scattering (SRS) of ethanol. The wavelengths of the three-color laser are 631, 532, and 447 nm, respectively, and the gamut space that can cover is 116% of the Rec. 2020 standard gamut in the CIE1976 color space.

Heterogating Gel Iontronics: A Revolution in Biointerfaces and Ion Signal Transmission.

Currently, existing iontronic systems are limited and struggle to process electronic-to-multi-ionic transport, resulting in interchange inefficiencies and incompatibilities between artificial ion devices and biological tissue interfaces. The development of heterogating gel iontronics offers a significant advancement in bridging this gap, drawing inspiration from the complex ionic transmission mechanisms found in biological synapses within neural networks. These heterogating gels utilize a biphasic architecture, where the heterointerface effect constructs ionic transfer energy barriers, enabling distinct signal transmission among different ions.

Protective effects of Nogo-B deficiency in NAFLD mice and its multiomics analysis of gut microbiology and metabolism.

Background: Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver ailment that can lead to serious conditions such as cirrhosis and hepatocellular carcinoma. Hepatic Nogo-B regulates glucose and lipid metabolism, and its inhibition has been shown to be protective against metabolic syndrome. Increasing evidence suggests that imbalances in the gut microbiota (GM) and lipid metabolism disorders are significant contributors to NAFLD progression.

Successful treatment of sepsis-induced cardiomyopathy with 36 hours refractory ventricular fibrillation: A case report.

Sepsis-induced cardiomyopathy (SIC) is generally characterized by decreased cardiac ejection fraction (EF) reversibility, less cardiac response to fluid resuscitation and catecholamine, and rarely complicated with refractory ventricular fibrillation (RVF). Once RVF is induced, the mortality rate of sepsis patients will be greatly increased. In this case, we reported a 26-year-old female patient who was diagnosed sepsis-induced cardiomyopathy (SIC), presented with RVF for 36 hours.

New compatible pair of TCM: Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation.

Objective: Drug-induced liver injury (DILI), a type of acute inflammation, has sparked significant concern owing to its unpredictability and severity. Psoraleae Fructus (PF), an edible Chinese herb widely used in traditional Chinese medicine (TCM), causes liver injury. Therefore, the elucidation of the mechanism underlying PF-induced liver injury and the search for more effective means of detoxification using herbal compatibility has become an urgent issue.

Optimization and Modelling of the Physical and Mechanical Properties of Grass Fiber Reinforced with Slag-Based Composites Using Response Surface Methodology.

The construction industry's high energy consumption and carbon emissions negatively impact the ecological environment; large-scale construction projects consume much energy and emit a significant amount of CO into the atmosphere. Statistics show that 30% of energy loss and 40% of solid waste in the construction industry are generated during construction. Therefore, reducing emissions during construction has significant research potential and value.

Correction: Affective computing for human-machine interaction a bionic organic memristor exhibiting selective activation.

Correction for 'Affective computing for human-machine interaction a bionic organic memristor exhibiting selective activation' by Bingjie Guo , , 2024, https://doi.org/10.1039/D3MH01950K.

Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by drug pair.

Objective: Acute lung injury (ALI) is characterized by inflammation and currently lacks an efficacious pharmacological intervention. The medicine combination of (LJF) and (FF) demonstrates combined properties in its anti-infective, anti-inflammatory, and therapeutic effects, particularly in alleviating respiratory symptoms. In previous studies, Chinese medicine has shown promising efficacy in lipopolysaccharides (LPS)-induced ALI.

LINC00963 Represses Osteogenic Differentiation of hBMSCs via the miR-10b-5p/RAP2A/AKT Axis.

Osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for human bone formation. Long non-coding RNAs (lncRNAs) are critical regulators in osteogenic differentiation. This study aimed to explore the function and mechanisms of long intergenic non-protein coding RNA 963 (LINC00963) in affecting osteogenesis.

Affective computing for human-machine interaction a bionic organic memristor exhibiting selective activation.

Affective computing, representing the forefront of human-machine interaction, is confronted with the pressing challenges of the execution speed and power consumption brought by the transmission of massive data. Herein, we introduce a bionic organic memristor inspired by the ligand-gated ion channels (LGICs) to facilitate near-sensor affective computing based on electroencephalography (EEG). It is constructed from a coordination polymer comprising Co ions and benzothiadiazole (Co-BTA), featuring multiple switching sites for redox reactions.

Unveiling Small-Sized Plastic Particles Hidden behind Large-Sized Ones in Human Excretion and Their Potential Sources.

Health risks of microplastic exposure have drawn growing global concerns due to the widespread distribution of microplastics in the environment. However, more evidence is needed to understand the exposure characteristics of microplastics owing to the limitation of current spectrum technologies, especially the missing information on small-sized particles. In the present study, laser direct infrared spectroscopy and thermal desorption-gas chromatography-mass spectrometry combined pyrolysis using a tubular furnace (TD-GC/MS) were employed to comprehensively detect the presence of plastic particles down to 0.

Broadband and ascendant nonlinear optical properties of the wide bandgap material GaN nanowires.

Gallium nitride (GaN) nanowire, as a type of wide bandgap nanomaterial, has attracted considerable interest because of its outstanding physicochemical properties and applications in energy storage and photoelectric devices. In this study, we prepared GaN nanowires via a facile chemical vapor deposition method and investigated their nonlinear absorption responses ranging from ultraviolet to near-infrared in the z-scan technology under irradiation by picosecond laser pulses. The experiment revealed that GaN nanowires exhibit remarkable nonlinear absorption characteristics attributed to their wide bandgap and nanostructure, including saturable absorption and reverse saturable absorption.

The important role of EPS in mediated biosynthesis of CdS QDs: Comparative study of EPS-intact and EPS-free.

In this study, we investigated the adsorption of Cd(II) and the biosynthesis of CdS quantum dots (QDs) mediated by cells of sulfate-reducing bacteria before and after the removal of EPS to determine whether EPS or the cell wall plays a major role. Potentiometric titration revealed that the concentration of proton-active binding sites on cells with EPS (EPS-intact) was notably higher than that on cells without EPS (EPS-free) and that the sites were predominantly carboxyl, phosphoryl, hydroxyl, and amine groups. The protein content in EPS-intact cells was higher, and thus the Cd(II) adsorption capacity was stronger.

Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction.

In the realm of autoimmune and inflammatory diseases, the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) signaling pathway has been thoroughly investigated and established. Despite this, the clinical approval of drugs targeting the cGAS-STING pathway has been limited. The Total glucosides of paeony (TGP) is highly anti-inflammatory and is commonly used in the treatment of rheumatoid arthritis (RA), emerged as a subject of our study.

Low-Power Perovskite Neuromorphic Synapse with Enhanced Photon Efficiency for Directional Motion Perception.

The advancement of artificial intelligent vision systems heavily relies on the development of fast and accurate optical imaging detection, identification, and tracking. Framed by restricted response speeds and low computational efficiency, traditional optoelectronic information devices are facing challenges in real-time optical imaging tasks and their ability to efficiently process complex visual data. To address the limitations of current optoelectronic information devices, this study introduces a novel photomemristor utilizing halide perovskite thin films.

Ion-Concentration-Hopping Heterolayer Gel for Ultrahigh Gradient Energy Conversion.

Conventional solid ion channel systems relying on single one- or two-dimensional confined nanochannels enabled selective and ultrafast convective ion transport. However, due to intrinsic solid channel stacking, these systems often face pore-pore polarization and ion concentration blockage, thereby restricting their efficiency in macroscale ion transport. Here, we constructed a soft heterolayer-gel system that integrated an ion-selective hydrogel layer with a water-barrier organogel layer, achieving ultrahigh cation selectivity and flux and effectively providing high-efficiency gradient energy conversion on a macroscale order of magnitude.

A Self-Oscillated Organic Synapse for In-Memory Two-Factor Authentication.

Entering the era of AI 2.0, bio-inspired target recognition facilitates life. However, target recognition may suffer from some risks when the target is hijacked.

The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.

Background: HBV infection can result in severe liver diseases and is one of the primary causes of liver cell carcinoma-related mortality. Liuwei Wuling tablet (LWWL) is a traditional Chinese medicine formula, with a protecting liver and decreasing enzyme activity, usually used to treat chronic hepatitis B with NAs in clinic. However, its main active ingredients and mechanism of action have not been fully investigated.

Removal efficiency of antibiotic residues, antibiotic resistant bacteria, and genes across parallel secondary settling tank and membrane bioreactor treatment trains in a water reclamation plant.

Antimicrobial resistance is recognized as a potent threat to human health. Wastewater treatment facilities are viewed as hotspots for the spread of antimicrobial resistance. This study provides comprehensive data on the occurrences of 3 different antibiotic resistant opportunistic pathogens (with resistance to up to 5 antibiotics), 13 antibiotic resistant genes and intI1, and 22 different antimicrobial residues in a large water reclamation plant (176 million gallons per day) that runs a conventional Modified Ludzack-Ettinger (MLE) reactor followed by a secondary settling tank (SST) and membrane bioreactor (MBR) in parallel.

Machine learning based peri-surgical risk calculator for abdominal related emergency general surgery: a multicenter retrospective study.

Background: Currently, there is a lack of ideal risk prediction tools in the field of emergency general surgery (EGS). The American Association for the Surgery of Trauma recommends developing risk assessment tools specifically for EGS-related diseases. In this study, we sought to utilize machine learning (ML) algorithms to explore and develop a web-based calculator for predicting five perioperative risk events of eight common operations in EGS.

Bicontinuous vitrimer heterogels with wide-span switchable stiffness-gated iontronic coordination.

Currently, it remains challenging to balance intrinsic stiffness with programmability in most vitrimers. Simultaneously, coordinating materials with gel-like iontronic properties for intrinsic ion transmission while maintaining vitrimer programmable features remains underexplored. Here, we introduce a phase-engineering strategy to fabricate bicontinuous vitrimer heterogel (VHG) materials.

Tissue accumulation of microplastics and potential health risks in human.

Microplastics have become ubiquitous throughout the environment. Humans constantly ingest and inhale microplastics, increasing concerns about the health risks of microplastic exposure. However, limited data impedes a full understanding of the internal exposure to microplastics.