Publications by authors named "Wu Yuan Yuan"

Study Design: Retrospective case-control study.

Objective: To examine the differences in various clinical indicators between Kümmell's disease (KD) and osteoporotic vertebral compression fractures (OVCF), in order to assist in the diagnosis of KD and provide a foundation for further analysis of its risk factors.

Summary Of Background Data: The mechanisms underlying the progression of OVCF to KD remain unclear, and research analyzing the indicators between the two conditions is still limited.

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Epidural electrical stimulation (EES) could restore motor function of paralyzed limbs of patients with spinal cord injury (SCI). However, its invasiveness limits its application in early stage of injury. Photobiomodulation (PBM) utilizes infrared light for percutaneous irradiation of the spinal cord to protect nerve tissue, delay muscle atrophy, and can be applied in early stage of SCI due to its non-invasiveness.

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Background: Miller fisher syndrome (MFS) is a variant of Guillain-Barré syndrome, an acute immune-mediated peripheral neuropathy that is often secondary to viral infections. Anti-ganglioside antibodies play crucial roles in the development of MFS. The positive rate of ganglioside antibodies is exceptionally high in MFS patients, particularly for anti-GQ1b antibodies.

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Purpose: Tumor initiating cells (TICs) or cancer stem cells (CSCs) are considered to be the main culprit of hepatocellular carcinoma (HCC) initiation and progression, nevertheless the mechanism by which tumor microenvironment maintains the HCC 'stemness' is not fully understood. This study aims to investigate the effect of regulatory T cells (Tregs) on the TICs characteristics of HCC.

Methods: Immunocytochemistry, flow cytometry, real-time PCR, western blot, in vitro sphere-formation, and in vivo tumorigenesis assay were used to detect HCC 'stemness'.

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The secretory leukocyte protease inhibitor (SLPI) is mainly produced by immune cells and various epithelial cells, and is regulated by a variety of cytokines, such as transforming growth factor β1, interleukin 1β and tumor necrosis factor α. In addition to commonly known anti-protease activity, it has been found in recent years that SLPI plays essential roles in anti-apoptosis, regulating cell cycle, cell differentiation and proliferation, and inhibiting inflammatory response. SLPI can also assist the immune system to clear pathogens/damaged cells by enhancing the phagocytic function of phagocytes, so as to ameliorate tissue damage and promote repair.

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The recovery of biopolymers, particularly alginate-like extracellular polymers, from municipal sludge represents a promising step toward sustainable sludge treatment practices. Originating from wastewater plants in complexly polluted environments, alginate-like extracellular polymers carry potential environmental risks concerning their reuse. This study employs ultrahigh-performance liquid chromatography-tandem mass spectrometry to investigate the distribution coefficients and occurrence of alginate-like extracellular polymers and sulfamethoxazole.

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This study aims to investigate the impact of Kuntai Capsules(KTC) on polycystic ovarian syndrome(PCOS) rat models and explore the underlying mechanism. Fifty female SD rats were randomly divided into five groups(10 rats in each group), including control group, model group, low-, medium-, and high-dose KTC group. Except for the control group, the other groups were injected with dehydroepiandrosterone(DHEA) combined with a high-fat diet(HFD) to induce the PCOS rat model for 28 days.

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Background: The frequent exacerbator phenotype of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is characterized by experiencing at least two exacerbations per year, leading to a significant economic burden on healthcare systems worldwide. Although several biomarkers have been shown to be effective in assessing AECOPD severity in recent years, there is a lack of studies on markers to predict the frequent exacerbator phenotype of AECOPD. The current study aimed to develop a new predictive model for the frequent exacerbator phenotype of AECOPD based on rapid, inexpensive, and easily obtained routine markers.

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Central nervous system (CNS) diseases have become one of the leading causes of death in the global population. The pathogenesis of CNS diseases is complicated, so it is important to find the patterns of the disease to improve the treatment strategy. Microglia are considered to be a double-edged sword, playing both harmful and beneficial roles in CNS diseases.

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Alzheimer's disease (AD) is a progressive neurodegenerative disease for which there is a lack of effective therapeutic drugs. There is great potential for natural products to be used in the development of anti-AD drugs. P-coumaric acid (PCA), a small molecule phenolic acid widely distributed in the plant kingdom, has pharmacological effects such as neuroprotection, but its anti-AD mechanism has not been fully elucidated.

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This study was to evaluate the efficacy of an integrated mycotoxin-mitigating agent in reducing the adverse effects of co-occurring dietary aflatoxin B deoxynivalenol and ochratoxin A on broiler breeder hens. 360 30-week-old Hubbard Efficiency Plus broiler breeder hens were allocated into four groups and received a basal diet (BD; Control), BD added 0.15 mg/kg aflatoxin B+1.

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Objective: To analyze the immunological phenotype of chronic myeloid leukemia (CML), and explore its characteristics and significance.

Methods: The immunophenotypes of 40 CML children and 40 controls were analyzed by multicolor flow cytometry. CD45/SSC, as the basic gate, was used to delineate neutrophils.

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Article Synopsis
  • Interferon-induced tetrapeptide repeat (IFIT) family proteins play a critical role in the antiviral immune response and include four main members: IFIT1, IFIT2, IFIT3, and IFIT5.
  • Research suggests that IFIT proteins are involved in various physiological processes, regulating immune cell differentiation and homeostasis, and are linked to several autoimmune diseases.
  • The review discusses the biological functions of IFIT proteins in autoimmune diseases, proposing their potential as biomarkers and therapeutic targets to improve diagnosis and treatment strategies.
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Article Synopsis
  • - A series of silver(I) complexes with O-phenanthroline were created and analyzed using various techniques like IR, MS, NMR, and X-ray crystallography to confirm their structure and properties.
  • - The cytotoxic effects of one complex, P-131, were tested on cancer cell lines (HCT-116, HeLa, MDA-MB-231) and a normal cell line (LO2), revealing that P-131 is more effective against cancer cells and safer for normal cells compared to cisplatin, with a lower IC value for HCT-116 (0.86 μM).
  • - P-131 was shown to inhibit DNA synthesis, raise reactive oxygen species levels, and demonstrated
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This study was to evaluate the efficacy of TOXO-XL (XL), an integrated mycotoxin-mitigating agent, on aflatoxin B (AFB)-induced damage in Leghorn male hepatoma (LMH), porcine jejunum epithelial cell line (IPEC-J2) and porcine alveolar macrophages (3D4/21) cells, and to explore its potential mechanisms. The results showed that 30% inhibition concentration (IC) of AFB in LMH, IPEC-J2 and 3D4/21 cells was 0.5, 15.

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Rheumatoid arthritis (RA) is a chronic autoimmune disease of unexplained causes. Its pathological features include synovial tissue hyperplasia, inflammatory cell infiltration in joint cavity fluid, cartilage bone destruction, and joint deformation. C-C motif chemokine ligand 3 (CCL3) belongs to inflammatory cell chemokine.

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The essential oils of Ligusticum chuanxiong Hort. (CXEO) are considered to be important parts of the pharmacological action of Ligusticum chuanxiong Hort. CXEO have a wide range of applications in various fields.

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Article Synopsis
  • Acute kidney injury (AKI) is a serious condition that can lead to high morbidity and mortality, and can progress to chronic kidney disease, with renal ischemia-reperfusion (IR) as a major cause.
  • Changes in the expression of erythropoietin homodimer receptor (EPOR) and its heterodimer with β common receptor (EPOR/βcR) are significant in the development and repair of AKI, with EPOR aiding in fibrosis and EPOR/βcR promoting repair.
  • This review explores the roles and mechanisms of EPOR and EPOR/βcR, including their effects on apoptosis, inflammation, and repair processes after IR, highlighting the need for better understanding to improve treatment strategies
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Article Synopsis
  • - A series of gallium(III) complexes were created and characterized using X-ray crystallography and density functional theory, focusing mainly on their cytotoxic effects against various human cancer cell lines.
  • - One specific complex, CP-, showed significant effectiveness in killing colon cancer cells (HCT116) with comparatively lower toxicity than conventional drugs like cisplatin and oxaliplatin.
  • - The study revealed that CP- induces apoptosis in cancer cells by affecting DNA-related protein expression and also demonstrated potential for use in colon cancer diagnosis and treatment due to its desirable emissive properties.
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A macrocyclic tetra-imidazolium salt () based on quinoxaline was prepared and characterized. The recognition of to nitro compounds was investigated by fluorescence spectroscopy, H NMR titrations, MS, IR spectroscopy, and UV/vis spectroscopy. The results displayed that was able to effectively differentiate -dinitrobenzene from other nitro compounds via the fluorescence method.

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Background: Gallium (III) metal-organic complexes have been shown to have the ability to inhibit tumor growth, but the poor water solubility of many of the complexes precludes further application. The use of materials with high biocompatibility as drug delivery carriers for metal-organic complexes to enhance the bioavailability of the drug is a feasible approach.

Methods: Here, we modified the ligands of gallium 8-hydroxyquinolinate complex with good clinical anticancer activity by replacing the 8-hydroxyquinoline ligands with 5-bromo-8-hydroxyquinoline (HBrQ), and the resulting Ga(III) + HBrQ complex had poor water solubility.

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Article Synopsis
  • Agroecosystems contribute significantly to nitric oxide (NO) emissions, with upland cropping systems emitting more NO than paddy fields, but uncertainties about these emissions and their regulating factors remain.
  • Various field studies have been conducted to analyze NO emissions and potential mitigation strategies, which form the basis of this study's meta-analysis.
  • Results from 49 peer-reviewed references revealed that NO emissions varied across different cropping systems in China, correlating positively with nitrogen input in certain systems while showcasing a need for better management practices to mitigate emissions.
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Despite the significant efficacy of acupuncture in alleviating anxiety and depression, the mechanism remains unclear. In recent years, functional magnetic resonance imaging (fMRI) technology has provided a visual method for deciphering the mechanism of acupuncture in treating anxiety and depression. This paper summarized the clinical studies about the imaging changes of anxiety and depression during the treatment with acupuncture under fMRI.

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Background: Patients with recurrent implantation failure (RIF) may have more uterine contractions. Several observational studies suggested that atosiban administration around embryo transfer resulted in higher pregnancy rates in RIF patients. This study aimed to evaluate the effect of atosiban given before fresh embryo transfer on pregnancy outcomes of women with RIF.

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