Fecal occult blood affects intestinal microbial community structure in colorectal cancer.

Background: Gut microbes have been used to predict CRC risk. Fecal occult blood test (FOBT) has been recommended for population screening of CRC.

Objective: To analyze the effects of fecal occult blood test (FOBT) on gut microbes.

Comprehensive retrospect and future perspective on bacteriophage and cancer.

Background: Researchers gradually focus on the relationship between phage and cancer.

Objective: To summarize the research hotspots and trends in the field of bacteriophage and cancer.

Methods: The downloaded articles were searched from the Web of Science Core Collection database from January 2008 to June 2023.

Escherichia coli on colorectal cancer: A two-edged sword.

Escherichia coli (E. coli) is a ubiquitous symbiotic bacterium in the gut, and the diversity of E. coli genes determines the diversity of its functions.

Gut microbial subtypes and clinicopathological value for colorectal cancer.

Background: Gut bacteria are related to colorectal cancer (CRC) and its clinicopathologic characteristics.

Objective: To develop gut bacterial subtypes and explore potential microbial targets for CRC.

Methods: Stool samples from 914 volunteers (376 CRCs, 363 advanced adenomas, and 175 normal controls) were included for 16S rRNA sequencing.

Recent trends: Retractions of articles in the oncology field.

Background: In recent years, there has been a surge in media reports on articles being retracted after publication. This issue has gained significant attention, particularly due to the consecutive large-scale retractions carried out by renowned international publishers, which have aroused widespread concern in the society.

Objective: To analyze the data of retracted articles and retraction trends.

Action of m6A-related gene signatures on the prognosis and immune microenvironment of colonic adenocarcinoma.

N6-methyladenosine (m6A) modification in human tumor cells exerts considerable influence on crucial processes like tumorigenesis, invasion, metastasis, and immune response. This study aims to comprehensively analyze the impact of m6A-related genes on the prognosis and immune microenvironment (IME) of colonic adenocarcinoma (COAD). Public data sources, predictive algorithms identified m6A-related genes and differential gene expression in COAD.

Third-generation PacBio sequencing to explore gut bacteria and gender in colorectal cancer.

Background: Gut bacteria have an important influence on colorectal cancer (CRC). The differences of gut bacteria between genders have been the hot spots.

Objective: To analyze the relationship between gut bacteria and gender differences in patients with CRC.

Age and aging process alter the gut microbes.

Background: Gut microbes and age are both factors that influence the development of disease. The community structure of gut microbes is affected by age.

Objective: To plot time-dependent gut microbe profiles in individuals over 45 years old and explore the correlation between age and gut microbes.

Advances in single-cell sequencing technology in microbiome research.

With the rapid development of histological techniques and the widespread application of single-cell sequencing in eukaryotes, researchers desire to explore individual microbial genotypes and functional expression, which deepens our understanding of microorganisms. In this review, the history of the development of microbial detection technologies was revealed and the difficulties in the application of single-cell sequencing in microorganisms were dissected as well. Moreover, the characteristics of the currently emerging microbial single-cell sequencing (Microbe-seq) technology were summarized, and the prospects of the application of Microbe-seq in microorganisms were distilled based on the current development status.

CFViSA: A comprehensive and free platform for visualization and statistics in omics-data.

Introduction: The rapid growth of omics technologies has led to the use of bioinformatics as a powerful tool for unravelling scientific puzzles. However, the obstacles of bioinformatics are compounded by the complexity of data processing and the distinct nature of omics data types, particularly in terms of visualization and statistics.

Objectives: We developed a comprehensive and free platform, CFViSA, to facilitate effortless visualization and statistical analysis of omics data by the scientific community.

Identification of enterotype and its predictive value for patients with colorectal cancer.

Background: Gut microbiota dysbiosis involved in the pathogenesis of colorectal cancer (CRC). The characteristics of enterotypes in CRC development have not been determined.

Objective: To characterize the gut microbiota of healthy, adenoma, and CRC subjects based on enterotype.

GPX3 is a key cholesterol-related gene associated with prognosis and tumor-infiltrating T cells in colorectal cancer.

High cholesterol is an important factor inducing colorectal cancer (CRC). The study aims to determine the key genes and regulatory mechanism associated with tumor-infiltrating T cells underlying cholesterol-induced CRC. Gene expression data and clinical data from CRCS in The Cancer Genome Atlas (TCGA) were selected for differential expression and survival analysis.

Colorectal cancer and gut viruses: a visualized analysis based on CiteSpace knowledge graph.

Background: Gut microbiome is a complex community of microbes present in the human gut and plays an important role in the occurrence and progression of colorectal cancer (CRC). However, the relationship between virus and CRC has not been fully understood.

Objective: To explore the hot spots and research trends in the field of CRC and virus.

Cholesterol induction in CD8 T cell exhaustion in colorectal cancer via the regulation of endoplasmic reticulum-mitochondria contact sites.

Background: Hypercholesterolemia is one of the risk factors for colorectal cancer (CRC). Cholesterol can participate in the regulation of human T cell function and affect the occurrence and development of CRC.

Objective: To elucidate the pathogenesis of CRC immune escape mediated by CD8 T cell exhaustion induced by cholesterol.

Identification of Molecular Targets of Bile Acids Acting on Colorectal Cancer and Their Correlation with Immunity.

Background: Bile acids (BAs) are closely related to the occurrence and development of colorectal cancer (CRC), but the specific mechanism is still unclear.

Aims: To identify potential targets related to BAs in CRC and analyze the correlation with immunity.

Methods: The expression of BAs and CRC-related genes in TCGA was studied and screened using KEGG.

Single-cell transcriptome analysis reveals T population heterogeneity and functions in tumor microenvironment of colorectal cancer metastases.

Cell mediated immune escape, a microenvironment factor, induces tumorigenesis and metastasis. The purpose of this study was to display the characteristics of T cell populations in immune microenvironments for colorectal cancer (CRC) metastasis. Unsupervised cluster analysis was conducted to identify functionally distinct T cell clusters from 3,003 cells in peripheral blood and 4,656 cells in tissues.

Gut bacteria and sex differences in colorectal cancer.

Differences in gut bacteria that are associated with the occurrence and development of colorectal cancer (CRC) exist between sexes, and males have a higher morbidity of CRC. Clinical data for the relationship between gut bacteria and sexes in patients with CRC are not available and are needed to support individualized screening and treatment programmes. To analyse the relationship between gut bacteria and sexes in patients with CRC.

Analysis of bacterial diversity and community structure in gastric juice of patients with advanced gastric cancer.

Background: The occurrence and development of gastric cancer are related to microorganisms, which can be used as potential biomarkers of gastric cancer.

Objective: To screen the microbiological markers of gastric cancer from the microorganisms of gastric juice.

Methods: Gastric juice samples were collected from 61 healthy people and 78 patients with gastric cancer (48 cases of early gastric cancer and 30 cases of advanced gastric cancer).

Prediction model of colorectal cancer (CRC) lymph node metastasis based on intestinal bacteria.

Background: Lymph node metastasis is the main metastatic mode of CRC. Lymph node metastasis affects patient prognosis.

Objective: To screen differential intestinal bacteria for CRC lymph node metastasis and construct a prediction model.

Using whole-genome sequencing (WGS) to plot colorectal cancer-related gut microbiota in a population with varied geography.

Background: Colorectal cancer (CRC) is a multifactorial disease with genetic and environmental factors. Regional differences in risk factors are an important reason for the different incidences of CRC in different regions.

Objective: The goal was to clarify the intestinal microbial composition and structure of CRC patients in different regions and construct CRC risk prediction models based on regional differences.

Biological roles of toll-like receptors and gut microbiota in colorectal cancer.

Colorectal cancer (CRC) is one of the most considerably common malignancies of the alimentary system, with high mortality and incidence rates.  The present study suggested that the occurrence of CRC is closely related to bacteria, as the large intestine is a gathering place for human micro-organisms. However, the nosogenesis of bacteria leading to tumorigenesis is still obscure.

Novel acetylation-related gene signatures for predicting the prognosis of patients with colorectal cancer.

Histone acetylation may affect the tumorigenesis and prognosis of colorectal cancer (CRC). However, there is still a lack of studies exploring the effect of acetylation-related genes on the prognosis of CRC. To explore the role of acetylation-related genes in CRC prognosis using bioinformatics strategies, the expression data and survival information of CRC patients were collected from the Gene Expression Omnibus.