Spin Magnetic Effect Activate Dual Site Intramolecular O─O Bridging for Nickel-Iron Hydroxide Enhanced Oxygen Evolution Catalysis.

The oxygen evolution reaction (OER) involves the recombination of diamagnetic hydroxyl (OH) or water (HO) into the paramagnetic triplet state of oxygen (O). The spin conservation of oxygen intermediates plays a crucial role in OER, however, research on spin dynamics during the catalytic process remains in its early stages. Herein, β-Ni(OH) and Fe-doped β-Ni(OH) (NiFe(OH)) are utilized as model catalysts to understand the mechanism of spin magnetic effects at iron (III) sites during OER.

The Association of Persistent Hyperuricemia With Liver Function and the Management of Uric Acid Levels: Insights From a Three-Year Prospective Cohort Study.

Objective: The association of long-term hyperuricemia with liver function remains less well understood. This prospective cohort study aimed to investigate the relationship between hyperuricemia and liver function as well as other metabolic and cardiovascular parameters.

Methods: We enrolled 375 participants with hyperuricemia and 599 normouricemic controls.

Diagnostic Accuracy of a Point-Of-Care aMMP-8 Test for Discriminating Periodontal Health Status in Adults: Validation Trials and Updated Meta-Analysis.

Aim: To evaluate the diagnostic accuracy of an active matrix metalloproteinase-8 (aMMP-8) point-of-care oral rinse test (POC-ORT) for predicting periodontitis in treatment-naïve subjects in two independent studies and update a recent meta-analysis.

Methods: The aMMP-8 POC-ORT index test was performed in a representative population in Hong Kong, China, and a consecutive convenience sample in Shanghai, China. The reference standard was the 2017 World Workshop classification of periodontal diseases.

The intervention of B. longum metabolites in Fnevs' carcinogenic capacity: A potential double-edged sword.

Colorectal cancer (CRC) ranks among the most prevalent malignant tumors globally. Fusobacterium nucleatum and its metabolites are effective biological targets for colon cancer promotion. Probiotics such as Bifidobacterium can block the occurrence and development of CRC by regulating the host intestinal mucosal immunity, eliminating carcinogens, and interfering with tumor cell proliferation and apoptosis.

Nano structural regulation of lignin and evaluation of its ultraviolet light absorption properties through quantum chemistry calculations.

Lignin, a biomass-derived material containing chromophores, possesses the potential to serve as a versatile organic ultraviolet (UV) light screening agent. By employing quantum chemical computation techniques, an amphoteric deep eutectic solvent (DES) based on sulfamic acid was purposefully designed and engineered to create a solvent system tailored for the nanoparticle formation and functionalization of lignin. As confirmed by experimental evidence, the size of the modified lignin nanoparticles (LNPs) varies from 168.

Deep Red-Light-Mediated Nitric Oxide and Photodynamic Synergistic Antibacterial Therapy for the Treatment of Drug-Resistant Bacterial Infections.

Infections caused by persistent, drug-resistant bacteria pose significant challenges in inflammation treatment, often leading to severe morbidity and mortality. Herein, the photosensitizer rhodamine derivatives are selected as the light-trapping dye and the electron-rich substituent N-nitrosoaminophen as the nitric oxide (NO)-releasing component to develop a multifunctional (deep) red-light activatable NO photocage/photodynamic prodrug for efficient treatment of wounds and diabetic foot infections. The prodrug, RhB-NO-2 integrates antimicrobial photodynamic therapy (aPDT), NO sterilization, and NO-mediated anti-inflammatory properties within a small organic molecule and is capable of releasing NO and generating Reactive oxygen species (ROS) when exposed to (deep) red laser (660 nm).

5G Remote Robot-Assisted Hepatobiliary and Pancreatic Surgery: A Report of Five Cases and a Literature Review.

Background: This study aimed to explore the feasibility and safety of using 5G communication technology for domestic surgical robots to perform ultra-remote hepatobiliary and pancreatic surgery.

Methods: A retrospective analysis was conducted on the clinical data of five cases of ultra-remote domestic robot-assisted laparoscopic hepatobiliary and pancreatic surgery completed at Sir Run Run Shaw Hospital, Zhejiang University School of Medicine (referred to as Hangzhou, Zhejiang) and Sir Run Run Shaw Hospital, Alaer Hospital, Zhejiang University School of Medicine (referred to as Alaer city, Xinjiang) from February to September 2023. The main system of the operating desk at Hangzhou, Zhejiang, uses 5G network signal transmission to remotely control the bedside operating system at Alaer City, Xinjiang.

[AKBA combined with doxorubicin inhibits proliferation and metastasis of triple-negative breast cancer MDA-MB-231 cells and xenograft growth in nude mice].

Objectives: To investigate the synergistic inhibitory effects of AKBA and doxorubicin on malignant phenotype of triple-negative breast cancer (TNBC) MDA-MB-231 cells.

Methods: CCK-8 assay was used to determine the 48-h IC of AKBA and doxorubicin in MDA-MB-231 cells, and SynergyFinder was employed to calculate the synergistic index and the optimal concentrations of the two agents. MDA-MB-231 cells treated with AKBA (22.

Social isolation profiles and conditional process analysis among postoperative enterostomy patients with colorectal cancer.

Purpose: This study aimed to identify social isolation latent profiles and analyze the specific mechanisms in which social support, resilience, and posttraumatic growth associated social isolation from the perspective of positive psychology. Suggestions were offered to improve the mental health status of postoperative enterostomy patients with colorectal cancer.

Methods: This was a cross-sectional survey.

Predicting higher risk factors for COVID-19 short-term reinfection in patients with rheumatic diseases: a modeling study based on XGBoost algorithm.

Background: Corona virus disease 2019 (COVID-19) reinfection, particularly short-term reinfection, poses challenges to the management of rheumatic diseases and may increase adverse clinical outcomes. This study aims to develop machine learning models to predict and identify the risk of short-term COVID-19 reinfection in patients with rheumatic diseases.

Methods: We developed four prediction models using explainable machine learning to assess the risk of short-term COVID-19 reinfection in 543 patients with rheumatic diseases.

The Efficacy and Safety Profile of Balanced Propofol Sedation for Bronchoscopy.

Purpose: We conducted a prospective, real-world study to evaluate the efficacy and safety of balanced propofol sedation (BPS) in bronchoscopy and identify an advantageous sedation regimen for such procedures.

Patients And Methods: The participants were placed in four groups based on their sedation regimen (exposure factor): the M-S group (midazolam + sufentanil for traditional sedation), R-S group (remimazolam + sufentanil for traditional sedation), M-S-P group (midazolam + sufentanil + propofol for BPS), and R-S-P group (remimazolam + sufentanil + propofol for BPS). The primary outcomes included satisfaction metrics (satisfaction of the patients, endoscopic physicians, and nurses) and follow-up questionnaires.

Innovative formaldehyde adsorption with optimized deep eutectic solvents: An experiment and multilevel computational chemistry approach.

Formaldehyde, a hazardous gas that is exposed to everyone every day, has been proven to pose an elevated risk of respiratory problems, allergies, and chronic diseases. Adsorption technologies have proven to be a straightforward and labor-saving method to reduce indoor formaldehyde levels. Currently, extensive research has been conducted utilizing Deep Eutectic Solvents (DES) as adsorbents for harmful gases, yet the adsorption and conversion mechanisms for formaldehyde remain unclear.

A scalable and durable polydimethylsiloxane-coated nanoporous polyethylene textile for daytime radiative cooling.

Radiative cooling technology with zero-energy consumption and zero-carbon emission has drawn enormous attention. However, the high-cost manufacture, limited scalability, and narrow application scopes remain major impediments to radiative cooling commercialization. Here, we present a bilayer PDMS/nanoPE fabricated by an automatic film applicator for high-performance passive daytime radiative cooling.

Prediction acrylamide contents in fried dough twist based on the application of artificial neural network.

Acrylamide forms through the reaction between reducing sugars and asparagine in the thermal processing of food. Detection measures like LC-MS, HPLC are time-consuming and costly, which inspired us to use back propagation-artificial neural networks (BP-ANN) based on a genetic algorithm to establish an acrylamide prediction model in fried dough twist. The effects of frying time and temperature on acrylamide contents, as well as the color difference and acid value at different time and temperature were determined.

Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism.

Background: The association between mitochondrial dysfunction and multiple metabolic adaptations is increasingly being proven. We previously elucidated that mitochondrial complex I deficiency can promote glycolysis in mut-p53 SW480 cells. However, studies have revealed a phenotype with attenuated glycolysis but enhanced fatty acid oxidation (FAO) in invasive tumors.

Corrigendum: Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.

[This corrects the article DOI: 10.3389/fphar.2023.

The Role of Pharmacogenetic-Based Pharmacokinetic Analysis in Precise Breast Cancer Treatment.

Given the high prevalence of breast cancer and the diverse genetic backgrounds of patients, a growing body of research emphasizes the importance of pharmacogenetic-based pharmacokinetic analysis in optimizing treatment outcomes. The treatment of breast cancer involves multiple drugs whose metabolism and efficacy are influenced by individual genetic variations. Genetic polymorphisms in drug-metabolizing enzymes and transport proteins are crucial in the regulation of pharmacokinetics.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19.

The RNA-dependent RNA polymerase (RdRp), 3C-like protease (3CL), and papain-like protease (PL) are pivotal components in the viral life cycle of SARS-CoV-2, presenting as promising therapeutic targets. Currently, all FDA-approved antiviral drugs against SARS-CoV-2 are RdRp or 3CL inhibitors. However, the mutations causing drug resistance have been observed in RdRp and 3CL from SARS-CoV-2, which makes it necessary to develop antivirals with novel mechanisms.

Transcriptomics integrated with metabolomics reveals the effect of benzo[a]pyrene exposure on acute lung injury.

Benzo[a]pyrene (BaP), a major harmful component in PM2.5, is widely present in automobile emissions and atmospheric pollution. BaP exposure directly targets the lungs, often resulting in acute lung injury (ALI).

A digital pathology model for predicting radioiodine-avid metastases on initial post-therapeutic I scan in patients with papillary thyroid cancer.

Accurate postoperative assessment is critical for optimizing I therapy in patients with papillary thyroid cancer (PTC). This study aimed to develop a pathology model utilizing postoperative digital pathology slides to predict lymph node and/or distant metastases on post-therapeutic I scan after initial I treatment in PTC patients. A retrospective analysis was conducted on 229 PTC patients who underwent total or near-total thyroidectomy and subsequent I treatment after levothyroxine (LT4) withdrawal between January 2022 and August 2023.