VNF Chain Placement for Large Scale IoT of Intelligent Transportation.

With the advent of the Internet of things (IoT), intelligent transportation has evolved over time to improve traffic safety and efficiency as well as to reduce congestion and environmental pollution. However, there are some challenging issues to be addressed so that it can be implemented to its full potential. The major challenge in intelligent transportation is that vehicles and pedestrians, as the main types of edge nodes in IoT infrastructure, are on the constant move.

Scalable TiCT MXene Interlayered Forward Osmosis Membranes for Enhanced Water Purification and Organic Solvent Recovery.

The design of nanosheets interlayer between the substrate and polyamide layer has attracted growing attention to improve the performance of thin-film composite membranes. However, the membrane size is limited by current fabrication methods such as vacuum filtration. Herein, a high-performance MXene (TiCT) interlayered polyamide forward osmosis (FO) membrane is fabricated based on a combination of a facile and scalable brush-coating of MXene on nylon substrates and the interfacial polymerization process.

Chemical constituents and their cytotoxicities from mushroom Tricholoma imbricatum.

Two undescribed triterpenes, tricholimbrins A and B, three undescribed steroids, tricholimbrins C‒E, one undescribed 4-chromanone derivative, along with 27 known compounds were isolated from fruiting bodies of the mushroom Tricholoma imbricatum. Tricholimbrins A and B are two polycyclic triterpenoids with a carbon degradation, while tricholimbrin C is a ring-rearranged steroid containing an aromatic moiety that might be derived from an ergosterol. Isocyathisterol, 3β,15α-dihydroxyl-(22E,24R)-ergosta-5,8(14),22-trien-7-one, demethylincisterol A, and volemolide showed cytotoxicities to six human cancer cell lines.

Physical, Rheological, and Morphological Properties of Asphalt Reinforced by Basalt Fiber and Lignin Fiber.

Studies show that each kind of fiber has its own advantages in improving the properties of asphalt binders. However, there are very limited research studies about mixed fiber-reinforced asphalt (MFRA). In this study, two kinds of fibers, basalt fiber (BF) and lignin fiber (LF), were selected to reinforce SBS (styrene-butadiene-styrene triblock copolymer)-modified asphalt, which is now widely used in pavement engineering.

Ferromagnetic CoSe broadband photodetector at room temperature.

Broadband infrared photodetectors based on two-dimensional (2D) materials which are the research focus in the infrared field, have wide applications in remote sensing, thermal imaging, and astronomy observation. In this article, the photodetector based on 2D ferromagnetic material CoSe is studied at room temperature, demonstrating the air-stable, broadband, and up to long wavelength properties. The CoSe material is applied to infrared photodetectors for the first time.

A novel device to prevent errors in medication dosing and dispensing.

Erroneous intravenous drug administration has a high probability of causing patient morbidity or mortality during anesthesia. Anesthesiologists are cognizant of this longstanding issue, which has prompted the development of a variety of different protocols and solutions designed to ameliorate the problem and ultimately improve patient outcomes. Unfortunately, no definitive solution has been developed yet.

A QSAR study that compares the ability of bisdioxopiperazine analogs of the doxorubicin cardioprotective agent dexrazoxane (ICRF-187) to protect myocytes with DNA topoisomerase II inhibition.

The cardiotoxicity caused by doxorubicin and extravasation injury caused by anthracyclines is reduced by the clinically approved bisdioxopiperazine drug dexrazoxane. Dexrazoxane is a rings-closed analog of EDTA and is hydrolyzed in vivo to a form that strongly binds iron. Its protective effects were originally thought to be due to the ability of its metabolite to remove iron from the iron-doxorubicin complex, thereby preventing oxygen radical damage to cellular components.

A novel rat model of ocular hypertension by a single intracameral injection of cross-linked hyaluronic acid hydrogel (Healaflow ).

To create a novel animal model of ocular hypertension via the intracameral injection of Healaflow. Unilateral chronic ocular hypertension model of rats was created by the intracameral injection of 3 μL Healaflow. The IOP of subjects was monitored.

Strain engineering and lattice vibration manipulation of atomically thin TaS films.

Beside the extraordinary structural, mechanical and physical properties of two-dimensional (2D) materials, the capability to tune properties strain engineering has shown great potential for nano-electromechanical systems. External strain, in a controlled manner, can manipulate the optical and electronic properties of the 2D materials. We observed the lattice vibration modulation in strained mono- and few-layer tantalum sulfide (TaS).

LncRNA NEAT1 promotes proliferation of chondrocytes via down-regulation of miR-16-5p in osteoarthritis.

Background: Non-coding RNAs are endogenous regulators of gene expression that have been implicated in the pathogenesis of various diseases, including osteoarthritis (OA). Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) and miR-16-5p are up-regulated in OA tissues; however, their functions have not been clarified.

Methods: Chondrocyte ATDC5 was used as a cell model.

A Review on Current Development of Membranes for Oil Removal from Wastewaters.

The current situation with the problems associated with the removal of oil from wastewaters by membranes is being explored. Many types of membranes have been investigated-organic polymers, inorganic or ceramic species and hybrids of the two. Polymeric membranes can be designed to facilitate the passage of oil, but the more successful approach is with hydrophilic types that encourage the passage of water.

Delayed in toilet training association with pediatric lower urinary tract dysfunction: A systematic review and meta-analysis.

Background: Globally, attitudes and practices towards toilet training have changed several decades ago and children are completing toilet training at a later age compared to previous generations. Concurrently, there has been an increase in the incidence of pediatric bladder bowel dysfunction (BBD), including lower urinary tract dysfunction (LUTD). Whether the fact of delayed toilet training may negatively impact the ability of children to obtain bladder and bowel control and cause LUT dysfunction remains controversial.

ISO-alpha-acids improve the hematoma resolution and prevent peri-hematoma inflammations by transforming microglia via PPARgamma-CD36 axis in ICH rats.

Objective: To elucidate the effects of ISO-α-acids (IAAs), a PPAR-γ agonist, on ICH rats and its potential mechanism.

Material And Methods: The Sprague Dawley rats ICH model was induced by stereotactic injecting of 100 μl autologous artery blood. Ninety male rats were randomly allocated to five groups: autologous blood and IAAs (IAA); received autologous blood, IAAs and PPAR-γ inhibitor (IAA + GW9662); autologous blood and normal Saline (Saline); only autologous blood (Mock); and only needle injection (Sham).

Intracranial Pressure Monitoring-Aided Management Associated with Favorable Outcomes in Patients with Hypertension-Related Spontaneous Intracerebral Hemorrhage.

To investigate the effect of intracranial pressure (ICP) monitoring on the functional outcome of patients with hypertension-related spontaneous intracerebral hemorrhage (ICH). We included 196 patients with Glasgow Coma Scale (GCS) scores of 3-12 in this observational study, of which 103 underwent ICP monitors. Binary and ordinal regression analyses were used to estimate the effect of ICP monitoring on the functional outcome.

Detoxification and reclamation of hydrometallurgical arsenic- and trace metals-bearing gypsum via hydrothermal recrystallization in acid solution.

Arsenic- and trace metals-bearing gypsum (As-gypsum) is one of the major hazardous solid wastes produced from metallurgical industry that poses a serious threat to the environment. However, the method for effective extraction of As and trace metals from As-gypsum is still lacking. In this study, simultaneous extraction of As and trace metals from a hydrometallurgical As-gypsum via hydrothermal recrystallization in acid solution was investigated.

Characterization of Fe(AsO)Cl(OH)·5HO, a new ferric arsenite hydroxychloride precipitated from FeCl-AsO-HCl solutions relevant to arsenic immobilization.

Tooeleite (Fe(AsO)SO(OH)·4HO) is widely precipitated for direct As(III) removal from sulfate-rich industrial effluents. However, whether or not Fe(III)-As(III)-Cl(-I) precipitate is produced in chloridizing leaching media for As immobilization is almost unknown. This work founded the existence of ferric arsenite (hydroxy)chloride as a new mineral for As(III) removal.

Bifunctional Catalysts for Reversible Oxygen Evolution Reaction and Oxygen Reduction Reaction.

Metal-air batteries (MABs) and reversible fuel cells (RFCs) rely on the bifunctional oxygen catalysts for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). Finding efficient bifunctional oxygen catalysts is the ultimate goal and it has attracted a great deal of attention. The dilemma is that a good ORR catalyst is not necessarily efficient for OER, and vice versa.

Trends of Intra-Cranial Bacterial Infection in Patients Requiring Emergency Neurosurgery.

Intra-cranial bacterial infection is a serious complication in emergency neurosurgical patients, and few data are available on the trends of these infections and the rates of antibacterial drug resistance. We surveyed retrospectively the patients with intra-cranial bacterial infection in our emergency neurosurgical center between January 2009 and December 2018. Demographic characteristics, causative bacteria, and antimicrobial susceptibility test results were collected.

In Situ Observation of Crystalline Silicon Growth from SiO at Atomic Scale.

The growth of crystalline Si (c-Si) via direct electron beam writing shows promise for fabricating Si nanomaterials due to its ultrahigh resolution. However, to increase the writing speed is a major obstacle, due to the lack of systematic experimental explorations of the growth process and mechanisms. This paper reports a systematic experimental investigation of the beam-induced formation of c-Si nanoparticles (NPs) from amorphous SiO under a range of doses and temperatures by in situ transmission electron microscopy at the atomic scale.

Weighted gene expression profiles identify diagnostic and prognostic genes for lung adenocarcinoma and squamous cell carcinoma.

Objective: To construct a diagnostic signature to distinguish lung adenocarcinoma from lung squamous cell carcinoma and a prognostic signature to predict the risk of death for patients with nonsmall-cell lung cancer, with satisfactory predictive performances, good stabilities, small sizes and meaningful biological implications.

Methods: Pathway-based feature selection methods utilize pathway information as a priori to provide insightful clues on potential biomarkers from the biological perspective, and such incorporation may be realized by adding weights to test statistics or gene expression values. In this study, weighted gene expression profiles were generated using the GeneRank method and then the LASSO method was used to identify discriminative and prognostic genes.

Development of a pseudovirus-based assay for measuring neutralizing antibodies against Coxsackievirus A10.

Coxsackievirus A10 (CV-A10) has recently emerged as a major pathogen of hand, foot, and mouth disease in children worldwide. Currently no effective treatments are available; development of anti-CV-A10 vaccine is a most cost-effective way for CV-A10 prevention. Robust assay to measure neutralizing antibody (NtAb) titres elicited by vaccination would greatly prompt anti-CV-A10 vaccine development.

Application of Exercised-based Pre-rehabilitation in Perioperative Period of Patients with Gastric Cancer.

Objective: To analyze the difference between exercised-based pre-rehabilitation and postoperative rapid rehabilitation of gastric cancer patients.

Methods: The clinical data of 120 patients who underwent surgical treatment between 2016 and 2018 in our hospital with pathologically confirmed gastric cancer were retrospectively reviewed. According to the different treatments during the perioperative period, they were divided into exercised-based pre-rehabilitation group and postoperative rapid rehabilitation group.

Impact of Transverse Ultrasound Images on the Classification and Treatment of Pediatric Lateral Humeral Condyle Fractures.

Background: Pediatric lateral humeral condyle fractures (LHCFs) are sometimes misdiagnosed and inappropriately treated on the basis of x-ray radiographs because cartilage cannot be seen on radiographs. However, as a useful technique, transverse ultrasonography can accurately and readily determine the integrity of the cartilage hinge in pediatric LHCFs. The purpose of this study was to assess the reliability of the Jakob classification, the treatment plan, and the necessity for further examination of pediatric LHCFs with the use of x-ray with and without transverse ultrasound images.

Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity.

Animal and clinical studies have shown that mesenchymal stem cells (MSCs) play an important role in cartilage repair. The therapeutic effect of mesenchymal stem cells based therapies has been increasingly demonstrated to exosome-mediated paracrine secretion. Here, we investigated the cellular processes and mechanism of exosomes produced by conventional 2D culture (2D-Exos) and exosomes produced from 3D culture (3D-Exos) of umbilical MSCs (U-MSCs) in a hollow-fiber bioreactor for the treatment of cartilage repair.

Effect of freezing on recombinant hepatitis E vaccine.

Studies have revealed that vaccines are more often exposed to sub-zero temperatures during cold chain transportation than what was previously known. Such exposure might be detrimental to the potency of temperature-sensitive vaccines. The aim of this study was to evaluate the impact of exposure to freezing on the physicochemical properties and biological activities of recombinant hepatitis E (rHE) vaccine.