Apolipoprotein B Modifies the Association between Lipoprotein(a) and ASCVD Risk.

Background: Elevated lipoprotein(a) (Lp[a]) and apolipoprotein B (apoB) are individually associated with the risk of atherosclerotic cardiovascular disease (ASCVD). Moreover, previous basic research has implicated the potential interaction between apoB and Lp(a) in the atherogenic process. We aimed to determine whether apoB levels significantly modulate ASCVD risk associated with Lp(a) in a large community-based population without baseline cardiovascular disease.

Evaluation of SMA-13 Asphalt Mixture Reinforced by Different Types of Fiber Additives.

This research aims at systematically evaluating the properties of SMA-13 asphalt mixture reinforced by several fiber additives including flocculent lignin fiber (FLF), granular lignin fiber (GLF), chopped basalt fiber (CBF), and flocculent basalt fiber (FBF). Firstly, the thermal stability, moisture absorption, and oil absorption property of these fiber additives were analyzed. Secondly, the property of SMA-13 reinforced using four types of single fibers and two kinds of composite fibers (FLF + CBF and FLF + FBF) was comprehensively analyzed.

Artificial Intelligence Diagnosing of Oral Lichen Planus: A Comparative Study.

Early diagnosis of oral lichen planus (OLP) is challenging, which traditionally is dependent on clinical experience and subjective interpretation. Artificial intelligence (AI) technology has been widely applied in objective and rapid diagnoses. In this study, we aim to investigate the potential of AI diagnosis in OLP and evaluate its effectiveness in improving diagnostic accuracy and accelerating clinical decision making.

Localization and expression of C1QTNF6 in chicken follicles and its regulatory effect on follicular granulosa cells.

C1q/tumor necrosis factor-related protein 6 (C1QTNF6) is a newly discovered adiponectin analog that plays a significant role in female reproduction. However, its expression and function in chickens remain unclear. In this study, the full-length coding sequence (CDS) of chicken C1QTNF6 was cloned from adult chicken ovary.

The dynamic patterns of critical ecological areas in the Yellow River Basin are driven primarily by climate factors but threatened by human activities.

While the identification of critical ecological areas (CEAs) has been limited by the availability of resources, funds, and land space, these areas are central for maintaining the contributions from nature and ecosystem biodiversity. Thus, in this study, CEAs were systematically identified and classified via long-term ecosystem assessment with a multifunctionality-stability-integrity framework in the Yellow River Basin (YRB). The intensity and pathways of the driving factors of CEA dynamics were also determined by the geographical detector model (GDM) and the partial least squares structural equation model (PLS-SEM).

Biosynthetic potential of the gut microbiome in longevous populations.

Gut microbiome plays a pivotal role in combating diseases and facilitating healthy aging, and natural products derived from biosynthetic gene clusters (BGCs) of the human microbiome exhibit significant biological activities. However, the natural products of the gut microbiome in long-lived populations remain poorly understood. Here, we integrated six cohorts of long-lived populations, encompassing a total of 1029 fecal metagenomic samples, and employed the metagenomic single sample assembled BGCs (MSSA-BGCs) analysis pipeline to investigate the natural products and their associated species.

Efficacy of Ultrasound-Guided Interscalene Brachial Plexus Block for Acute Post-Hepatectomy Shoulder Pain: A Randomized Controlled Trial.

Objective: To investigate the efficacy of ultrasound-guided interscalene brachial plexus block in the treatment of shoulder pain following hepatectomy.

Design: A randomized controlled trial.

Methods: We conducted a single-center, randomized controlled trial.

From Small Data Modeling to Large Language Model Screening: A Dual-Strategy Framework for Materials Intelligent Design.

Small data in materials present significant challenges to constructing highly accurate machine learning models, severely hindering the widespread implementation of data-driven materials intelligent design. In this study, the Dual-Strategy Materials Intelligent Design Framework (DSMID) is introduced, which integrates two innovative methods. The Adversarial domain Adaptive Embedding Generative network (AAEG) transfers data between related property datasets, even with only 90 data points, enhancing material composition characterization and improving property prediction.

Histone variant H2AZ1 drives lung cancer progression through the RELA-HIF1A-EGFR signaling pathway.

Background: A growing body of evidence indicates that histone variants play an oncogenic role in cancer progression. However, the role and mechanism of histone variant H2AZ1 in lung cancer remain poorly understood. In this study, we aim to identify novel functions and molecular mechanisms of H2AZ1 in lung cancer.

Global Burden of Inflammatory Bowel Disease Among Children and Adolescents: A Comprehensive Analysis (1990-2019).

Objective: We summarize the global, regional, and national burden of inflammatory bowel disease (IBD) in children and adolescents from 1990 to 2019.

Methods: Based on the Global Burden of Disease Study 2019, the data of IBD in children and adolescents were analyzed by sex, age, year, and location. Joinpoint analysis was applied to assess the temporal trend of the disease burden.

Gray matter structural alterations of cortico-striato-thalamo-cortical loop in familial Paroxysmal Kinesigenic Dyskinesia.

Background: Previous studies have indicated that patients with Paroxysmal Kinesigenic Dyskinesia (PKD) exhibit reduced gray matter volume in certain brain regions within the cortico-striato-thalamo-cortical (CSTC) loop. However, a comprehensive investigation specifically targeting the CSTC loop in PKD has never been conducted.

Objectives: To provide evidence for the involvement of the CSTC loop in the pathogenesis of PKD from the perspective of structural alterations, this study carried out a surface-based morphometry (SBM), voxel-based morphometry (VBM), and structural covariance networks (SCN) combined analysis in familial PKD patients.

Analysis of neutrophil extracellular trap-related genes in Crohn's disease based on bioinformatics.

Crohn's disease (CD) presents with diverse clinical phenotypes due to persistent inflammation of the gastrointestinal tract. Its global incidence is on the rise. Neutrophil extracellular traps (NETs) are networks released by neutrophils that capture microbicidal proteins and oxidases targeting pathogens.

Fabrication of anti-freezing and self-healing hydrogel sensors based on carboxymethyl guar gum and poly(ionic liquid).

As classical soft materials, conductive hydrogels have attracted wide attention in the field of strain sensors due to their unique flexibility and conductivity. However, there are still challenges in developing conductive hydrogels with comprehensive mechanical strength, self-healing ability and sensitive sensing properties. In this paper, a novel PAV/CMGG hydrogel was prepared by a simple one-pot method through the introduction of 1-vinyl-3-butylimidazolium bromide (VBIMBr), acrylic acid (AA), carboxymethyl guar gum (CMGG) and AlCl.

Infectious wrist arthritis complicating acute carpal tunnel syndrome in a child: A CARE-compliant case report.

Introduction: The objective of this case report is to provide clinical evidence that acute infectious wrist arthritis in children can lead to the rare condition of acute carpal tunnel syndrome (ACTS). This article discusses in detail the characteristics of infectious wrist arthritis complicating ACTS in children in terms of etiology, pathogenic bacteria, treatment modalities, and sequelae to improve the understanding of this disease.

Patient Concerns: A 10-year-old male child presented with a 15-day history of swelling and pain in the left forearm, wrist, and hand.

The role of AdipoQ on proliferation, apoptosis, and hormone Secretion in chicken primary adenohypophysis cells.

Adiponectin (AdipoQ), an adipokine secreted by adipocytes, has been reported to exist widely in various cell types and tissues, including the adenohypophysis of chickens. However, the molecular mechanism by which AdipoQ regulates the function of chicken adenohypophysis remains elusive. In this study, we investigated the effects of AdipoQ on proliferation, apoptosis, secretion of related hormones (FSH, LH, TSH, GH, PRL and ACTH) and expression of related genes (FSHβ, LHβ, GnRHR, TSHβ, GH, PRL and ACTH) in primary adenohypophysis cells of chickens by using real-time fluorescent quantitative PCR (RT-qPCR), cell counting kit-8 (CCK-8), flow cytometry, enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) assays.

Increased EHD1 in trophoblasts causes RSM by activating TGFβ signaling†.

Background: Recurrent spontaneous miscarriage is one of the complications during pregnancy. However, the pathogenesis of recurrent spontaneous miscarriage is far from fully elucidated.

Objective: Since the endocytic pathway is crucial for cellular homeostasis, our study aimed to explore the roles of endocytic recycling, especially EH domain containing 1, a member of the endocytic recycling compartment, in recurrent spontaneous miscarriage.

24-Hour Urinary Sodium Excretion Is Associated With Increased Risk of Pancreatic Cancer: A Prospective Cohort Study.

Introduction: This study builds on previous research and its limitations, which indicate the need for further investigation in prospective cohorts. Our aim was to explore the association between estimated 24-hour urinary sodium excretion (indicative of daily sodium consumption) and the occurrence of pancreatic cancer in the UK Biobank's large prospective cohort.

Methods: Using the INTERSALT equation, the study computed estimated 24-hour urinary sodium excretion by analyzing the baseline spot urine sodium measurements of 434,372 individuals enrolled in the UK Biobank.

Spatiotemporal drivers of Nature's contributions to people: A county-level study.

Nature's contributions to people (NCP) encompass both the beneficial and detrimental effects of living nature on human quality of life, including regulatory, material, and non-material contributions. Globally, vital NCPs have been deteriorating, accelerated by changes in both natural and anthropogenic drivers over recent decades. Despite the often inevitable trade-offs between NCPs due to their spatially and temporally uneven distributions, few studies have quantitatively assessed the impacts of different drivers on the spatial and temporal changes in multiple NCPs and their interrelationships.

Estrogen promotes gonadotropin-releasing hormone expression by regulating tachykinin 3 and prodynorphin systems in chicken.

The "KNDy neurons" located in the hypothalamic arcuate nucleus (ARC) of mammals are known to co-express kisspeptin, neurokinin B (NKB), and dynorphin (DYN), and have been identified as key mediators of the feedback regulation of steroid hormones on gonadotropin-releasing hormone (GnRH). However, in birds, the genes encoding kisspeptin and its receptor GPR54 are genomic lost, leaving unclear mechanisms for feedback regulation of GnRH by steroid hormones. Here, the genes tachykinin 3 (TAC3) and prodynorphin (PDYN) encoding chicken NKB and DYN neuropeptides were successfully cloned.

Purely Organic Room-Temperature Phosphorescence Molecule for High-Performance Non-Doped Organic Light-Emitting Diodes.

Purely organic molecules with room-temperature phosphorescence (RTP) are potential luminescent materials with high exciton utilization for organic light-emitting diodes (OLEDs), but those exhibiting superb electroluminescence (EL) performances are rarely explored, mainly due to their long phosphorescence lifetimes. Herein, a robust purely organic RTP molecule, 3,6-bis(5-phenylindolo[3,2-a]carbazol-12(5H)-yl)-xanthen-9-one (3,2-PIC-XT), is developed. The neat film of 3,2-PIC-XT shows strong green RTP with a very short lifetime (2.