Multidisciplinary Approach Improves Eradication Rate and Safety in Refractory Helicobacter pylori Infection.

Introduction: Helicobacter pylori (HP) infection is prevalent worldwide and contributes to various gastrointestinal diseases. Eradication therapy is crucial in managing HP infection, but antibiotic resistance has led to refractory cases, complicating treatment outcomes and increasing the risk of adverse events. This study aimed to evaluate the effectiveness of a multidisciplinary approach, termed HP Multidisciplinary Team (MDT) Clinic, in improving eradication rates and safety in patients with refractory HP infection.

Association of metalloestrogens exposure with depression in women across reproductive lifespan.

Background: Exposure to metal could impact women's depression risk. However, the connection and mechanisms between metalloestrogens exposure and depression are still not fully understood. We aim to explore the associations between metalloestrogens and the risk of depression in women across reproductive lifespan.

Competing Risk Modeling with Bivariate Varying Coefficients to Understand the Dynamic Impact of COVID-19.

The coronavirus disease 2019 (COVID-19) pandemic has exerted a profound impact on patients with end-stage renal disease relying on kidney dialysis to sustain their lives. A preliminary analysis of dialysis patient postdischarge hospital readmissions and deaths in 2020 revealed that the COVID-19 effect has varied significantly with postdischarge time and time since the pandemic onset. However, the complex dynamics cannot be characterized by existing varying coefficient models.

tsRNAs: A Prospective, Effective Therapeutic Intervention for Neurodegenerative Diseases.

Background: Neurological disorders known as neurodegenerative diseases (NDDs) result in the slow loss of neurons in the central nervous system (CNS) or peripheral nervous system (PNS), as well as the collapse of neural networks in terms of structure and function. NDDs are expected to surpass cancer as the second biggest cause of mortality by 2040, according to World Health Organization (WHO) estimations. Neurons cannot effectively regenerate themselves because they are terminally differentiated.

Barley2035: A decade vision on barley research and breeding.

Barley (Hordeum vulgare ssp. vulgare) is one of the oldest founder crops in early human civilization, and has been widely dispersed around the globe to supply human life through livestock feeding and brewing industries. It has been used in innovative research of cytogenetics, biochemistry, and genetics since the early half of the 20 century, facilitated by its mode of reproduction through self-pollination, its true diploid status which has contributed to the accumulation of a plethora of germplasm and mutant resources.

Targeting Autophagy with Geniposide Ameliorates Atherosclerosis in [Formula: see text] Mice.

Atherosclerosis (AS) is a major cause of mortality worldwide. Geniposide (GP) has lipolytic and anti-inflammatory effects and is widely administered for the treatment of cardiovascular disease. There is considerable evidence for the importance of autophagy in the cardiovascular system, and GP can promote autophagy and improve AS.

A previously unidentified circRNA inhibits virus replication by regulating the miR-24-3p/KEAP1 axis.

Circular RNAs (circRNAs) exert diverse biological functions in different processes. However, the role of circRNAs during virus infection is mostly unknown. Herein, we explored the characteristics of host circRNAs using alphaherpesvirus pseudorabies virus (PRV) as a model.

Association between vertebral bone quality score and residual back pain following percutaneous vertebroplasty for osteoporotic vertebral compression fractures.

Background: Residual back pain (RBP) is one of the complications following percutaneous vertebroplasty (PVP) in older people with osteoporotic vertebral compression fractures (OVCFs). The vertebral bone quality (VBQ) score obtained from magnetic resonance imaging (MRI) can be used to evaluate bone quality. The objective of this study aimed to explore the potential relationship between the VBQ score and RBP after PVP.

Mechanical and electromechanical properties of 2D materials studied microscopy techniques.

Two-dimensional (2D) materials with van der Waals stacking have been reported to have extraordinary mechanical and electromechanical properties, which give them revolutionary potential in various fields. However, due to the atomic-scale thickness of these 2D materials, their fascinating properties cannot be effectively characterized in many cases using conventional measurement techniques. Based on typical microscopy techniques such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM), a range of microscopy techniques have been developed to systematically quantify the mechanical and electromechanical properties of 2D materials.

Virtual reality therapy in managing cancer pain in middle-aged and elderly: a systematic review and meta-analysis.

Background: Virtual reality technology has been proposed to rehabilitate cancer patients. This study aimed to summarize the effectiveness of virtual reality (VR)--based therapies for pain management in middle-aged and elderly cancer patients.

Methods: This meta-analysis was registered in PROSPERO (CRD42023400432).

Fully Printable Manufacturing of Miniaturized, Highly Integrated, Flexible Evaporation-Driven Electricity Generator Arrays.

Harvesting sustainable clean energy from natural water evaporation holds great promise to provide continuous power for portable and wearable electronics. However, poor portability and complex fabrication processes hinder the low-cost and large-scale integration of flexible evaporation-driven electricity generators (FEEGs). Herein, a fully-printed flexible evaporation-driven generator (PFEEG) is developed.

Antibiotic sorption onto MPs in terrestrial environment: a critical review of the transport, bioaccumulation, ecotoxicological effects and prospects.

Microplastics (MPs) and antibiotics are prevalent contaminants in terrestrial environment. MPs possess the ability to absorb antibiotics, resulting in the formation of complex pollutants. While the accumulation and fate of MPs and antibiotics in marine ecosystems have been extensively studied, their combined pollution behavior in terrestrial environments remains relatively underexplored.

Single-Nucleus and Spatial Transcriptome Profiling Delineates the Multicellular Ecosystem in Hepatocellular Carcinoma After Hepatic Arterial Infusion Chemotherapy.

Hepatic arterial infusion chemotherapy (HAIC) has emerged as a promising treatment strategy for hepatocellular carcinoma (HCC), but a detailed understanding of the multicellular ecosystem after HAIC treatment is lacking. Here, we collected tumor samples from treatment-naïve primary and post-HAIC HCC, and integrated single-nucleus RNA sequencing with spatial transcriptomics to characterize the tumor ecosystem in the post-HAIC HCC. Increased fractions and enhanced cellular communication of CD4 T, CD20 B, and dendritic cell subtypes were identified in post-HAIC tumors.

Clinical application of intramedullary nail fixation assisted by locking plates in segmental tibia fractures: A retrospective study.

It is unclear whether small plates are needed for augment fixation to provide a more stable mechanical environment in segmental fractures of the tibia treated with intramedullary nail. The purpose of this study was to investigate the efficacy of intramedullary nailing combined with locking plates in the treatment of segmental fractures of the tibia. This study included 41 patients with segmental tibia fractures between January 1, 2018 and January 1, 2023.

Planetary Gearboxes Fault Diagnosis Based on Markov Transition Fields and SE-ResNet.

The working conditions of planetary gearboxes are complex, and their structural couplings are strong, leading to low reliability. Traditional deep neural networks often struggle with feature learning in noisy environments, and their reliance on one-dimensional signals as input fails to capture the interrelationships between data points. To address these challenges, we proposed a fault diagnosis method for planetary gearboxes that integrates Markov transition fields (MTFs) and a residual attention mechanism.

Assessment of the Aging State for Transformer Oil-Barrier Insulation by Raman Spectroscopy and Optimized Support Vector Machine.

Accurate assessment of the aging state of transformer oil-barrier insulation is crucial for ensuring the safe and reliable operation of power systems. This study presents the development of indoor accelerated thermal aging experiments to simulate the degradation of oil-immersed barrier insulation within transformers. A series of samples reflecting various aging states was obtained and categorized into six distinct groups.

Phase Evolution in MnZnNiMgAlO High-Entropy Oxide Films by Heat Treatment.

In this work, Mn-Zn-Ni-Mg-Al multi-layer films were annealed in air at different temperatures to form spinel-structured MnZnNiMgAlO high-entropy oxide films. X-ray diffraction results demonstrate that the films possess a polycrystalline spinel phase as well as impurity phases: when annealed at 650 °C and 750 °C, MnO and AlO impurity phases exist; at 950 °C, an AlO impurity phase exists. Only at 850 °C does a pure spinel phase exist.

Laser-Induced Graphene Decorated with MOF-Derived NiCo-LDH for Highly Sensitive Non-Enzymatic Glucose Sensor.

Designing and fabricating a highly sensitive non-enzymatic glucose sensor is crucial for the early detection and management of diabetes. Meanwhile, the development of innovative electrode substrates has become a key focus for addressing the growing demand for constructing flexible sensors. Here, a simple one-step laser engraving method is applied for preparing laser-induced graphene (LIG) on polyimide (PI) film, which serves as the sensor substrate.

Effects of Precooling on Endurance Exercise Performance in the Heat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

An increasing number of studies have explored the effects of precooling on endurance exercise performance in the heat, yet the available results remain inconsistent. Therefore, this study aimed to investigate the effects of different precooling strategies on endurance exercise performance in the heat. A comprehensive search was conducted across PubMed, Web of Science, Cochrane, Scopus, and EBSCO database.

Trends in Consumption of Ultra-Processed Foods Among Adults in Southern China: Analysis of Serial Cross-Sectional Health Survey Data 2002-2022.

Background: Over time, there have been significant changes in the dietary patterns of the Chinese population with the emergence of ultra-processed foods (UPFs).

Methods: To ascertain the changes in UPFs intake among adults in southern China, over the past two decades, the study included residents aged 18 years and older who participated in the China National Nutrition Surveys in Guangdong province in 2002, 2012, and 2022. Dietary intake data were collected via three-day 24 h dietary recalls and weighing household foods and condiments.

Influence of Copper Valence in CuO/TiO Catalysts on the Selectivity of Carbon Dioxide Photocatalytic Reduction Products.

The Cu cocatalyst supported on the surface of TiO photocatalysts has demonstrated unique activity and selectivity in photocatalytic CO reduction. The valence state of copper significantly influences the catalytic process; however, due to the inherent instability of copper's valence states, the precise role of different valence states in CO reduction remains inadequately understood. In this study, CuO/TiO catalysts were synthesized using an in situ growth reduction method, and we investigated the impact of various valence copper species on CO photocatalytic reduction.

Utilizing Microbial Electrochemical Methods to Enhance Lycopene Production in .

Utilizing (), this study constructed a dual-chamber microbial electrosynthesis system, based on microbial electrolysis cells, that was capable of producing lycopene. Cultivation within the electrosynthesis chamber yielded a lycopene concentration of 282.3722 mg/L when the optical density (OD) reached 0.

Poly l-Lactic Acid Nanofiber Membrane Effectively Inhibits Liver Cancer Cells Growth and Prevents Postoperative Residual Cancer Recurrence.

Electrospun nanocarrier systems, widely employed in the medical field, exhibit the capability to encapsulate multiple drugs and mitigate complications. Doxorubicin hydrochloride (DOX) represents a frequently utilized chemotherapeutic agent for liver cancer patients. Sodium bicarbonate (SB) serves to neutralize the acidic tumor microenvironment, while ibuprofen (IBU) attenuates inflammatory factor production.

Mechanisms of anthraquinone dye Vat Blue 4 biodegradation by Pseudomonas aeruginosa WYT and genotoxicity assessment of its transformation products.

Dye biodegradation products may cause genotoxicity, raising concerns about the safety of bioremediated water. The underlying biotransformation mechanism and related genotoxicity during anthraquinone degradation remain unclear. In this study, we employed Pseudomonas aeruginosa WYT (PaWYT) to investigate the biotransformation of Vat Blue 4 (VB4), a dye with a typical anthraquinone structure and low bioavailability.