AKR1C1 interacts with STAT3 to increase intracellular glutathione and confers resistance to oxaliplatin in colorectal cancer.

Oxaliplatin (OXA), a platinum-based chemotherapeutic agent, remains a mainstay in first-line treatments for advanced colorectal cancer (CRC). However, the eventual development of OXA resistance represents a significant clinical challenge. In the present study, we demonstrate that the aldo-keto reductase 1C1 (AKR1C1) is overexpressed in CRC cells upon acquisition of OXA resistance, evident in OXA-resistant CRC cell lines.

Age, creatinine, and ejection fraction score is a risk factor for acute kidney injury after surgical aortic valve replacement.

Background: The incidence of acute kidney injury (AKI) increases after surgical aortic valve replacement (SAVR). This study aimed to characterize the risk factors of AKI after SAVR.

Methods And Results: We conducted a retrospective registry study based on data from 299 consecutive patients undergoing SAVR.

Clinical and Genetic characterization of 51 Patients with Congenital Fibrinogen Disorders from China.

Objective To investigate the classification, clinical manifestations, laboratory findings, and genetic mutations associated with hereditary fibrinogen disorders in Chinese population. Methods Between February 2015 and February 2022, 65 patients with congenital fibrinogen disorders (CFD) were identified at Wuhan Union Hospital. Comprehensive data were available for 51 patients, allowing for a retrospective analysis.

Development and Characterization of Biodegradable, Binderless Fiberboards from Eggplant Straw Fibers.

Currently, wood-based panels are mainly made from wood and adhesives containing formaldehyde. With the growing demand for raw materials and increasing concern for human health, the use of residues from annual crops to manufacture binder-free biodegradable biomass boards has attracted increasing interest. The aim of this study was to develop a biodegradable bio-board without any adhesives using eggplant straw fibers.

FAP-targeting biomimetic nanosystem to restore the activated cancer-associated fibroblasts to quiescent state for breast cancer radiotherapy.

Cancer associated fibroblasts (CAFs) are one of the most important stromal cells in the tumor microenvironment, playing a pivotal role in the development, recurrence, metastasis, and immunosuppression of cancer and treatment resistance. Here, we developed a core-shell biomimetic nanosystem termed as FAP-C NPs. This system was comprised of 4T1 extracellular vesicles fused with a FAP single-chain antibody fragment to form the biomimetic shell, and PLGA nanoparticles loaded with calcipotriol as the core.

Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study.

Traffic-related air pollution (TRAP) has been linked with numerous respiratory diseases. Recently, lung microbiome is proposed to be characterized with development and progression of respiratory diseases. However, the underlying effects of TRAP exposure on lung microbiome are rarely explored.

Muscle strength trajectories and outcomes in critically ill patients: A prospective multicentre cohort study.

Objectives: To investigate the trajectories and determinants of muscle strength in ICU patients and their impact on 1-, 6-, and 12-month mortality outcomes.

Design: Prospective multicenter cohort study.

Settings: Ten ICUs across five tertiary hospitals in Fujian Province, China.

Prediction Models for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis.

Background: Stroke is one of the most serious illnesses worldwide and is the primary cause of acquired disability among adults. Post-stroke cognitive impairment (PSCI) is a complication of stroke that significantly impacts patients' daily activities and social functions. Therefore, developing a risk prediction model for PSCI is essential for identifying and preventing disease progression.

Advanced Dual-Mode Microfluidic Sensing Platform Based on Amphiphilic Polymer-Capped Perovskite Nanozymes Induced Photoelectrochemical Signal Amplification and Fluorescence Emission.

A novel dual-mode microfluidic sensing platform integrating photoelectrochemical (PEC) and fluorescence (FL) sensors was developed for the sensitive monitoring of heart fatty acid binding protein (h-FABP). First, BiVO/AgInS (BVAIS) composites with excellent photoelectric activity were synthesized as sensing matrices. The BVAIS heterojunction with a well-matched internal energy level structure provided a stable photocurrent.

Global, regional, and national burden of myocarditis in children aged 0-14 years, 1990-2021: analysis for the global burden of disease study 2021.

Objective: There are limited epidemiological data on myocarditis in children aged 0-14 years. This study aims to investigate the trends in incidence, mortality, disability-adjusted life years (DALYs), and corresponding estimated annual percentage change (EAPC) of myocarditis in children aged 0-14 years from 1990 to 2021.

Methods: We utilized the 2021 Global Burden of Disease, Injuries, and Risk Factors Study (GBD) analytical tools to examine the incidence, mortality, and DALYs of myocarditis in children aged 0-14 years, considering factors such as age, sex, region, sociodemographic index (SDI), and data from 204 countries or regions.

Energetic MOF-derived FeC nanoparticles encased in N,S-codoped mesoporous pod-like carbon nanotubes for efficient oxygen reduction reaction.

The rational design of advanced oxygen reduction reaction (ORR) catalysts is essential to improve the performance of energy conversion devices. However, it remains a huge challenge to construct hierarchical micro-/meso-/macroporous nanostructures, especially mesoporous transport channels in catalysts, to enhance catalytic capability. Herein, motivated by the characteristics of energetic metal-organic frameworks (EMOFs) that produce an abundance of gases during high-temperature pyrolysis, we prepared a unique tetrazine-based EMOF-derived electrocatalyst (denoted as FeC@NSC-900) consisting of highly dispersed FeC nanoparticles and N,S-codoped mesoporous carbon nanotubes.

Mediating and moderating factors between stigma and adaptability to return to work for cancer survivors.

Adaptability to return to work is a process by which cancer survivors(CSs) utilize accessible resources to reconstruct themselves. While the stigma, financial situation and social support are known to influence their adaptability to return to work, the mechanisms by which these factors work remain unclear. This study proposes a moderated mediation model to signify a pathway linking stigma to the adaptability to return to work.

Comparative Effectiveness of Antivirals and Monoclonal Antibodies for Treating COVID-19 Patients Infected With Omicron Variant: A Systematic Review and Network Meta-Analysis.

Antiviral drugs likely remain effective against the SARS-CoV-2 Omicron variant, while monoclonal antibody (mAb) therapies have experienced drops in neutralizing ability. This systematic review and network meta-analysis aims to estimate the comparative effectiveness of antivirals and mAb therapies for treating COVID-19 patients infected with Omicron, capturing primarily acute outcomes. We searched multiple databases from July 4 to July 19, 2022, with updates through November 4, 2022.

A Novel Neuroprotective Derived Peptide of Erythropoietin Improved Cognitive Function in Vascular Dementia Mice.

The effective therapeutics for vascular dementia are still lacking. Here, we designed a novel derived peptide of erythropoietin-DEPO and evaluated its safety, erythropoiesis effect, and neuroprotective effects in mice of vascular dementia. For evaluating the safety and erythropoiesis, DEPO was injected into naive C57BL6 mice (n = 5) for 4-8 weeks, and venous blood was collected at 1, 2, and 4 weeks after DEPO treatment.

Development of a multi-functional naringin-loaded bioglass/carboxymethyl chitosan/silk fibroin porous scaffold for hemostasis and critical size bone regeneration.

Persistent bleeding and limited repair capacity greatly threaten patients with bone destruction. Designing inorganic-organic biomimetic scaffolds with quick hemostasis and osteogenesis functions will solve this problem. A novel degradable and naringin (NG) loaded porous scaffold (SCB-N) based on APTES-modified bioactive glass (ABG), carboxymethyl chitosan and silk fibroin is developed.

Engineering Mild-Photothermal Responsive and NO Donor Prussian Blue Nanozymes Using Mild Synthesis for Inflammation Regulation and Bacterial Eradication in Periodontal Disease.

Periodontitis, an infectious disease of periodontal tissues caused by oral bacterial biofilms, is characterized by reactive oxygen species (ROS) accumulation and immune microenvironment imbalance. Multifunctional nanozymes, leveraging their physiochemical properties and enzymatic activities, offer promising antibacterial and anti-inflammatory strategies for managing periodontitis. In particular, Prussian blue nanozymes (PBzymes) exhibit exceptional ROS control due to their robust catalytic activity, diverse antioxidant functions, and high biocompatibility.

Aggregation-Induced Electrochemiluminescence of Silica-Confined Tetraphenylethylene with Pd Nanocube-Loaded CoO Nanosheets as a Coreaction Accelerator for Sensitive Bioanalysis.

Aggregation-induced electrochemiluminescence (AIECL) provides a new approach for the development of novel electrochemiluminescence (ECL) strategies. Herein, a biosensor was constructed by incorporating 1,1,2,2-tetra(4-carboxylphenyl)ethylene (HTCPE) into a mesoporous silica nanosphere (MSN) to obtain a highly organized AIECL luminophore of (MSN-HTCPE) for signal antibody (Ab) labeling and using Pd nanocube (NC)-loaded CoO nanosheets (NSs) (PdNCs/CoONSs) as a novel coreaction accelerator. The confinement of HTCPE molecules in the MSN restricted the intramolecular rotation and thus enhanced the radiation transition of HTCPE.

Allergen Sensitization in Allergic Skin Diseases in Suzhou, East China: A Retrospective Study from 2021 to 2023.

Introduction: Allergen distribution varies geographically, and local epidemiological data can guide disease prevention and management. We investigated allergen sensitization among patients with three types of allergic skin disease in Suzhou, East China, from 2021 to 2023.

Methods: Serum-specific immunoglobulin E levels were analyzed from 4,603 patients who visited the First Affiliated Hospital of Soochow University between January 2021 and December 2023.

Cell-free DNA methylation signatures reflect the risk of vascular endothelial cell injury associated with traffic-related air pollution.

Traffic-related air pollution (TRAP) contains a plethora of hazardous pollutants, and is associated with a multitude of adverse health effects. However, up to now, no early biomarkers that can quickly reflect the health damage induced by TRAP. We conducted a randomized crossover trial in 35 healthy adults.

Clinical features, radiological findings and prognosis of microscopic polyangiitis with interstitial lung disease: a retrospective matched control study.

Background: The association between interstitial lung disease (ILD) and microscopic polyangiitis (MPA) has received increasing attention in recent years. However, there are still no studies comparing clinical characteristics and prognoses between MPA-ILD patients and patients with ANCA-negative ILDs. Therefore, the purpose of this study was to analyse a group of patients presenting MPA-ILD matched with patients exhibiting ANCA-negative ILDs to identify differences in their clinical characteristics and survival.

Incidence and Associated Factors of Postoperative Delirium in Adults Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Prospective Cohort Study.

Background: Delirium is one of the most common and serious complications after cardiac surgery with cardiopulmonary bypass (CPB). A comprehensive assessment of independent risk factors for postoperative delirium (POD) is essential for early detection and prevention.

Aims And Objectives: To investigate the incidence and independent associated factors of POD in adults undergoing cardiac surgery with CPB.

Trajectory and determinants of intensive care unit-acquired weakness in critical illness: A multicentre, prospective, longitudinal study.

Background: Intensive care unit-acquired weakness (ICU-AW) is prevalent and adversely affects patient outcomes. Muscle strength progression and response to rehabilitation differ across ICU populations. However, the trajectories, determinants and prognoses of muscle strength changes remain unclear.

Butorphanol Alleviates Hypoxia/Reoxygenation-Induced Myocardial Injury by Activating Wnt/β-Catenin Signal Pathway.

Ischemic heart disease remains a global health problem with high morbidity and mortality. Butorphanol, as a novel opioid, has been discovered with its cardioprotective properties. The purpose of this study was to explore that butorphanol can alleviate hypoxia/reoxygenation (H/R)-induced myocardial injury by activating the Wnt/β-catenin signal pathway.

BaTiO Doping Enhances Ultrasound-Driven Piezoelectric Bactericidal Effects of Fibrous Poly(L-Lactic Acid) Dressings to Accelerate Septic Wound Healing.

Bacterial invasion in infected skin wounds triggers inflammation and impedes healing. Current therapeutic strategies incorporating drug interventions within wound dressings often result in drug resistance and delayed healing. Here, we developed a comprehensive therapeutic modality integrating piezoelectric fibrous dressing with controlled ultrasound stimulation for efficient healing in an infected wound model.