The current research status of the mechanisms and treatment of radioactive brain injury.

Radioactive brain injury, a severe complication ensuing from radiotherapy for head and neck malignancies, frequently manifests as cognitive impairment and substantially diminishes patients' quality of life. Despite its profound impact, the pathogenesis of this condition remains inadequately elucidated, and efficacious treatments are notably absent in clinical practice. Consequently, contemporary interventions predominantly focus on symptom alleviation rather than achieving a radical cure or reversing the injury process.

Comprehensive Analysis of Sialylation-Related Gene Profiles and Their Impact on the Immune Microenvironment in Periodontitis.

Periodontitis is a chronic inflammatory disease strongly influenced by host's immune response. Aberrant sialylation on cell surface plays a key role in inflammation and immunity. This study aims to identify sialylation-related genes associated with periodontitis and explore their impact on periodontal immune microenvironment.

Isolated ipsilateral ptosis associated with ventral midbrain infarction: a case report and literature review.

Documented cases of ipsilateral ptosis caused by midbrain infarction remain rare. Herein, we present a patient with isolated ipsilateral ptosis that was initially considered to be a consequence of myasthenia gravis but was subsequently attributed to ventral midbrain infarction. We also discuss the possible underlying mechanisms; ipsilateral ptosis in our patient was attributed to selective damage of the levator palpebral muscle branch of the oculomotor nerve.

Induction sintilimab and chemotherapy followed by concurrent chemoradiotherapy for locally advanced esophageal cancer: a proof-of-concept, single-arm, multicenter, phase 2 trial.

Background: Concurrent chemoradiotherapy is the standard nonoperative treatment for locally advanced esophageal squamous cell carcinoma. However, local recurrence is still the main failure pattern, accounting for more than half of all treatment failures, indicating that the sensitivity of radiotherapy still needs to be improved. This trial aimed at demonstrating whether PD-1 inhibitors followed by chemoradiotherapy could promote esophageal tumor vascular normalization, alleviate hypoxia, and thus enhance radiosensitivity and improve local control.

Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets.

Periodontitis, which is related to various systemic diseases, is a chronic inflammatory disease caused by periodontal dysbiosis of the microbiota. Multiple factors can influence the interaction of periodontitis and associated inflammatory disorders, among which host immunity is an important contributor to this interaction. Innate immunity can be activated aberrantly because of the systemic inflammation induced by periodontitis.

[Diagnostic value and interventional treatment of elbow cyst by high frequency ultrasound].

Objective: To study and analyze the diagnostic value and interventional treatment value of high-frequency ultrasound for elbow cyst.

Methods: From February 2018 to February 2021, the data of 60 patients with elbow cyst treated by high-frequency ultrasound interventional therapy were retrospectively analyzed, including 30 males and 30 females with an average age of (30.93±5.

Machine Learning-Based Models for Assessing Postoperative Risk Factors in Patients with Cervical Cancer.

Rationale And Objectives: To investigate the value of machine learning-based radiomics, intravoxel incoherent motion (IVIM) diffusion-weighted imaging and its combined model in predicting the postoperative risk factors of parametrial infiltration (PI), lymph node metastasis (LNM), deep muscle invasion (DMI), lymph-vascular space invasion (LVSI), pathological type (PT), differentiation degree (DD), and Ki-67 expression level in patients with cervical cancer.

Materials And Methods: The data of 180 patients with cervical cancer were retrospectively analyzed and randomized 2:1 into a training and validation group. The IVIM-DWI and radiomics parameters of primary lesions were measured in all patients.

Role of Orai3-Mediated Store-Operated Calcium Entry in Radiation-Induced Brain Microvascular Endothelial Cell Injury.

Radiation-induced brain injury is a serious complication with complex pathogenesis that may accompany radiotherapy of head and neck tumors. Although studies have shown that calcium (Ca) signaling may be involved in the occurrence and development of radiation-induced brain injury, the underlying molecular mechanisms are not well understood. In this study, we used real-time quantitative polymerase chain reaction and Western blotting assays to verify our previous finding using next-generation sequencing that the mRNA and protein expression levels of Orai3 in rat brain microvascular endothelial cells (rBMECs) increased after X-ray irradiation.

Nickel hydroxide/sulfide hybrids: halide ion controlled synthesis, structural characteristics, and electrochemical performance.

Focusing on the synthesis of nickel-based materials (such as nickel sulfides, nickel hydroxides, and nickel oxides) is an urgent need in the fields of batteries, supercapacitors, and catalysis. However, their controlled synthesis still remains a great challenge because of the inadequate understanding of the control factor of their synthesis. A two-step solvo-/hydrothermal process with halide ion embedding/releasing was proposed to understand the effect of the halide ions on the synthesis and sulfidation of nickel hydroxy-halides.

X-Ray Causes mRNA Transcripts Change to Enhance Orai2-Mediated Ca Influx in Rat Brain Microvascular Endothelial Cells.

Radiation-induced brain injury is a serious and treatment-limiting complication of brain radiation therapy. Although endothelial cell dysfunction plays a critical role in the development of this pathogenesis, the underlying molecular mechanisms remain elusive. Primary cultured rat brain microvascular endothelial cells (BMECs) were divided into five groups without or with exposure of x-rays delivered at 5 Gy or 20 Gy.

Clinical efficacy of low-dose emetine for patients with COVID-19: a real-world study.

Objective: Emetine, an isoquinoline alkaloid that is enriched at high concentrations in the lung, has shown potent in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to better understand the effectiveness of low-dose emetine for patients with coronavirus disease 2019 (COVID-19).

Methods: In this real-world study, 63 patients with mild or common COVID-19 were recruited from Wuhan Fangcang Shelter Hospital and five COVID-19-designated hospitals in Anhui Province, China from February to March 2020.

Facile fabrication of core-shell structured Ni(OH)/Ni(PO) composite via one-step electrodeposition for high performance asymmetric supercapacitor.

Metal metaphosphates, particularly those with core-shell structure, have showed extraordinary potential in energy storage field due to their superior chemical and physical properties. However, the core-shell metal metaphosphates with high energy density in supercapacitor application is rarely reported. Here, the core-shell structured Ni(OH)/Ni(PO) (NNP) hybrid electrode were prepared by one-step electrodeposition, which exhibits a superior specific capacitance of 1477 F g at a current density of 1 A g.

Effect of X-rays on transcript expression of rat brain microvascular endothelial cells: role of calcium signaling in X-ray-induced endothelium damage.

Radiation-induced brain edema is a serious adverse effect of radiotherapy. Although there are many causes of radiation-induced brain edema, the pathogenesis is not clear and clinical treatment is not ideal. Therefore, knowing the differential expression of the brain microvascular endothelial cell (BMEC) transcriptome after brain radiotherapy may shed light on the pathogenesis of radiation-induced brain edema.

Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences.

Unlabelled: The global pandemic of COVID-19 has attracted extensive drug searching interets for the new coronavirus SARS-CoV-2. Although currently several of clinically used "old" drugs have been repurposed to this new disease for the urgent clinical investigation, there is still great demand for more effective therapies for the anti-infections. Here we report the discovery that an "old" drug Emetine could potently inhibit SARS-CoV-2 virus replication and displayed virus entry blocking effect in Vero cells at low dose.

Graphene oxide-drove transformation of NiS/NiS microbars towards NiS polyhedrons for supercapacitor.

NiS is regarded as one of the promising electrode materials for energy storage, but the difficulty in obtaining its pure phase hinders its wide applications. In this work, we introduced a novel method to in-situ synthesize NiS@reduced graphene oxide (rGO) composite, where graphene oxide (GO) was found to induce the oxidation of Ni to Ni and the morphology transformation from microbar to polyhedron during the hydrothermal process. The influence of the content and oxidation degree of GO on the phase composition and morphology of nickel sulfide is investigated.

Downregulation of EB virus miR-BART4 inhibits proliferation and aggressiveness while promoting radiosensitivity of nasopharyngeal carcinoma.

Objective: This study aims to explore the role of Epstein-Barr virus (EBV) miR-BART4 in occurrence and progression of nasopharyngeal carcinoma (NPC) and its effect on radiosensitivity.

Method: The expressions of EBV and miR-BART4 in 108 cases of NPC tissues and 97 cases of chronic nasopharyngeal inflammation tissues were determined by real time quantitative polymerase chain reaction (PCR), and the relationship between the expression of miR-BART4 and the clinicopathological features of NPC was analyzed. Cell lines, HONEl, CNEl, CNE2, C666-1, 6-10B, and NP-69 were used to compare the expression of miR-BART4, in which the CNE2 cells were selected for further experiments.

MicroRNA‑125 inhibits RKO colorectal cancer cell growth by targeting VEGF.

Colorectal cancer (CRC) is one of the major types of cancer and causes of mortality worldwide, and it remains the third most common cause of cancer‑associated mortality worldwide. MicroRNAs (miRNAs) are a class of small RNAs, which have been shown to be associated with CRC. In the present study, an MTT assay and proliferating cell nuclear antigen (PCNA) protein examination assay were performed to detect RKO cell viability.

Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy.

Colorectal cancer (CRC) is among the main tumor-related causes of death worldwide. The fact that the majority of the patients develop resistance to chemoradiotherapy (CRT) is a major obstacle for the treatment of CRC. In order to develop more effective treatment strategies, it is crucial to elucidate the mechanisms underlying the development of resistance to CRT.

Metal-Organic Framework-Derived CoZnC/Co Embedded in Nitrogen-Doped Carbon Nanotube-Grafted Carbon Polyhedra as a High-Performance Electrocatalyst for Water Splitting.

The development of efficient, low-cost, and stable electrocatalysts for overall water splitting is of great significance for energy conversion. Transition-metal carbides (TMCs) with high catalytic activity and low cost have attracted great interests. Nevertheless, utilizing an efficient catalyst for overall water splitting is still a challenging issue for TMCs.

Self-Supported Hierarchical FeCoNi-LTH/NiCoO/CC Electrodes with Enhanced Bifunctional Performance for Efficient Overall Water Splitting.

The development of advanced earth-abundant electrocatalysts for hydrogen production is highly desirable. In this paper, we report the design and synthesis of a novel and highly efficient electrode of NiCoO nanoneedles decorated with FeCoNi layered ternary hydroxides supported on carbon cloth (FeCoNi-LTH/NiCoO/CC) by a facile and efficient two-step approach. It exhibits superior bifunctional catalytic activities for the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in alkaline media, due to the special structure and strong synergies.

Expression of COX-2 and HER-2 in colorectal cancer and their correlation.

Aim: To detect the expression of COX-2 and HER-2 in colorectal cancer and to analyze their correlation and clinical significance.

Methods: A total of 1026 colorectal cancer surgical specimens were collected from patients treated from December 2002 to December 2007 at the First Affiliated Hospital of Anhui Medical University. All specimens were made into 4-μm slices.