Risk-based triage strategy by extended HPV genotyping for women with ASC-US cytology.

Objective: We attempted to evaluate the immediate high-grade squamous intraepithelial lesion-cervical intraepithelial neoplasia grade 2/3 or worse (HSIL-CIN2+/3+, hereafter referred to as CIN2+/3+) risk of specific human papillomavirus (HPV) genotype and form the precise risk-based triage strategy for atypical squamous cells of undetermined significance (ASC-US) women.

Methods: The clinical data of ASC-US women who underwent HPV genotyping testing and colposcopy were retrospectively reviewed. The distribution and CIN2+/3+ risks of specific HPV genotype were assessed by three approaches.

Facile Preparation of Sulfonated Polysulfone Composite Membranes with High Hydrophilicity and Visible-Light Driving Self-Cleaning Performance.

The photo-Fenton reaction can efficiently degrade organic pollutants and thus is applied intensively for clearing out membrane fouling. However, the pollutant removal efficiency is greatly limited by the redox cycle rate of Fe/Fe and the rapid recombination rate of the photogenerated electrons and holes. In order to overcome these drawbacks, a sulfonated polysulfone composite membrane was designed and prepared by incorporating titanium dioxide (TiO) nanoparticles into a sulfonated polysulfone membrane and sequentially forming β-FeOOHs on the membrane surface.

Na-K-ATPase/GLT-1 interaction participates in EGCG protection against cerebral ischemia-reperfusion injury in rats.

Background: In China, stroke is the primary cause of adult death and disability. Because of the increased rate of blood vessel reperfusion, it is important to prevent cerebral ischemia-reperfusion injury, in which glutamate (Glu) excitotoxicity plays a critical role. The most important Glu transporter, GLT-1, is essential for the regulation of Glu, which is dependent on Na-K-ATPase (NKA)-induced ion concentration gradient differences.

Connexin 43 contributes to perioperative neurocognitive disorder by attenuating perineuronal net of hippocampus in aged mice.

Background: Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anesthesia and surgery. The underlying mechanisms of PND are closely related to perineuronal nets (PNNs). PNNs, which are complexes of extracellular matrix primarily surrounding neurons in the hippocampus, play a critical role in neurocognitive function.

miR-468-3p suppresses osteogenic differentiation of BMSCs by targeting Runx2 and inhibits bone formation.

An improved understanding of the molecular actions underpinning bone marrow mesenchymal stem cell (BMSC) differentiation could highlight new therapeutics for osteoporosis (OP). Current evidence indicates that microRNAs (miRNAs) exert critical roles in many biological systems, including osteoblast differentiation. In this study, we examined miR-468-3p effects on osteogenic differentiation (OD).

Blue Quantum Dot Light-Emitting Diodes toward Full-Color Displays: Materials, Devices, and Large-Scale Fabrication.

Quantum dots (QDs) light-emitting diodes (QLEDs) are gaining significant interest for the next generation of display and lighting applications because of their wide color gamut, cost-effective solution processability, and good stability. The last decades have witnessed rapid advances in improving their efficiency and lifetime. So far, among the three primary colors of QLEDs devices, the performance of blue QLEDs is considerably inferior to that of green and red ones including Cd-based and Cd-free devices, which is a key bottleneck hindering QLEDs' application.

DNMT3a Deficiency Contributes to Anesthesia/Surgery-Induced Synaptic Dysfunction and Cognitive Impairment in Aged Mice.

Perioperative neurocognitive disorder (PND) is a severe postoperative complication in older patients. Epigenetic changes are hallmarks of senescence and are closely associated with cognitive impairment. However, the effects of anesthesia and surgery on the aging brain's epigenetic regulatory mechanisms and its impact on cognitive impairment remain unclear.

PCDHGA10 as a potential prognostic biomarker and correlated with immune infiltration in gastric cancer.

Background: Gastric cancer (GC) is one of the most common malignant tumors and is associated with poor prognosis. To improve the prognosis of GC patients, an effective immune-related prognostic biomarker is urgent. Here, we aim to explore the correlation between the expression of procalcitonin gamma subfamily A, 10 (PCDHGA10) and clinicopathological characteristics, especially its relation with tumor-infiltrating immune cells (TILs) in GC.

Suppression of Interfacial Oxidation in Core/Shell InP Quantum Dots through Solvent Assisted Core-Etching Strategy for Efficient Green Light-Emitting Diodes.

Indium phosphide (InP) quantum dots (QDs) are promising alternative heavy-metal CdSe QDs for light-emitting diode (LED) application. However, their highly reactive core surface is prone to oxidation, which reduces the photoluminescence quantum yield (PL QY) and impedes subsequent shell growth. Traditional etching methods using HF aqueous solution are problematic as water can induce reoxidation during or after etching.

Investigation on the Distribution of in Yuanshui Unique Fish Species National Aquatic Germplasm Resources Reserve Using Environmental DNA Technology.

Freshwater ecosystems face unprecedented challenges as the cumulative impact of human activities intensifies. While protected areas and species-specific conservation policies are widely implemented, their effectiveness remains difficult to gauge using traditional catch-based surveys. This research employed environmental DNA (eDNA) technology to assess the distribution of the endangered fish, , within the Yuanshui Unique Fish Species National Aquatic Germplasm Resources Reserve (YUFRR) in Hunan, China.

Effects of Applying Organic Amendments on Soil Aggregate Structure and Tomato Yield in Facility Agriculture.

Amendment significantly improves soil structure and promotes crop growth. To combat soil degradation and low crop yields in facility agriculture, it is crucial to study the optimal application rate of amendments. This study analyzed the effects of biochar, vermicompost, and mineral-source potassium fulvic acid on the stability of aggregate structure, soil nutrient content, and tomato yield in cambisols, providing a theoretical basis for improving the soil quality of plastic greenhouses in Southern China.

The Effects of the oxLDL/β2GPI/anti-β2GPI Complex on Macrophage Autophagy and its Mechanism.

Background: Previous research has established that the oxidized low-density lipoprotein/β2-glycoprotein I/anti-β2-glycoprotein I antibody (oxLDL/β2GPI/anti-β2GPI) complex can stimulate macrophages to secrete molecules associated with atherosclerosis (AS), such as monocyte chemotactic protein 1 (MCP-1), tissue factor (TF), and tumor necrosis factor-α (TNF-α). This complex also enhances the uptake of oxLDL, thereby accelerating foam cell formation through the Toll-like receptor-4/nuclear factor kappa B (TLR4/NF-κB) pathway. Given the critical role of macrophage autophagy in the instability of vulnerable atherosclerotic plaques, it is imperative to investigate whether the oxLDL/β2GPI/anti-β2GPI complex influences macrophage autophagy in AS.

Systemic immune-inflammation index values are associated with non-melanoma skin cancers: evidence from the National Health and Nutrition Examination Survey 2010-2018.

Introduction: The systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, has recently been investigated as a prognostic marker in several tumors. However, the SII has rarely been reported in skin cancers. In this study, we aimed to assess the association between SII values and the risk of occurrence of skin cancers.

Bio-inspired e-skin with integrated antifouling and comfortable wearing for self-powered motion monitoring and ultra-long-range human-machine interaction.

Electronic skin (e-skin) inspired by the sensory function of the skin demonstrates broad application prospects in health, medicine, and human-machine interaction. Herein, we developed a self-powered all-fiber bio-inspired e-skin (AFBI E-skin) that integrated functions of antifouling, antibacterial, biocompatibility and breathability. AFBI E-skin was composed of three layers of electrospun nanofibrous films.

NaturalEssential Oils: A Promising Therapy Way for Treating Ischemic Stroke.

Stroke is an acute cerebrovascular disease with high morbidity, mortality, and disability, making it the second leading cause of death worldwide. Ischemic stroke (IS) accounts for the majority of strokes, and its pathogenesis is complex, often involving complications and sequelae. Currently, conventional clinical approaches are ineffective, with few drugs available for intravenous thrombolysis and mechanical thrombolysis limited by a short time window.

Sedative-Hypnotic Effect and Mechanism of Carbon Nanofiber Loaded with Essential Oils of ( Hort.) and Finger Citron ( L. var. ) on Mice Models of Insomnia.

(1) Background: Insomnia is a neurological illness that poses a significant threat to both physical and mental health. It results in the activation of neuroglial cells, heightened neuroinflammation, oxidative stress, and disruptions in the Hypothalamic-Pituitary-Adrenal (HPA) axis. (CX) and Finger citron (FC) are frequently utilized botanicals for addressing sleeplessness.

Association analysis between serum asprosin and metabolic characteristics, Complications in type 2 diabetic patients with different durations.

Aims/introduction: To investigated the association between serum asprosin and metabolic characteristics in type 2 diabetes mellitus patients with different durations.

Materials And Methods: A total of 436 patients with type 2 diabetes mellitus were enrolled in this study from the community health service center in southeastern Shanxi Province. All the patients were divided into two groups according to their diabetes duration: diabetes duration ≤5 years group (n = 132) and diabetes duration ≥10 years group (n = 304).

Baicalein enhances cisplatin sensitivity in cervical cancer cells by promoting cuproptosis through the Akt pathway.

Resistance to cisplatin presents a major obstacle in managing advanced-stage cervical cancer. Cuproptosis, a newly identified form of cell death induced by copper ions, has potential in overcoming chemoresistance. But the application of cuproptosis in cervical cancer resistant to cisplatin has not yet been reported.

Manganese-Modified Aluminum Adjuvant Enhances both Humoral and Cellular Immune Responses.

Aluminum adjuvants remain the most commonly used vaccine adjuvants. Being rather effective in triggering humoral immunity, however, aluminum adjuvants usually show limited abilities in activating cellular immunities. Herein, by adding manganese ions during the preparation of aluminum adjuvant, a manganese-modified aluminum (Mn-Al) adjuvant is obtained, which can effectively stimulate both humoral and cellular immune responses.

The relationship between 25-hydroxy vitamin D and serum asprosin in patients with type 2 diabetes in the community.

Objectives: This study aimed to investigate the link between 25-hydroxy vitamin D and serum asprosin in individuals with type 2 diabetes within the community. The goal was to provide a foundation for clinical interventions.

Methods: Between November 2019 and July 2021, data from 463 patients with type 2 diabetes were consistently gathered at a community health service station in Southeast Shanxi Province.

Hsa_circ_0001359 in Serum Exosomes: A Promising Marker to Predict Bronchopulmonary Dysplasia in Premature Infants.

Objective: This prospective study is to explore the role of specific circRNAs in predicting the development of bronchopulmonary dysplasia (BPD).

Methods: From July 1, 2021 to December 1, 2021, peripheral blood samples were collected from 62 premature infants with gestational age (GA) ≤32 weeks on the 7th, 14th, and 28th day after birth. Then, on the 28th day, the included infants were divided into the BPD group and the non-BPD group according to the definition of BPD.

Quantum-Confined Perovskite Nanocrystals Enabled by Negative Catalyst Strategy for Efficient Light-Emitting Diodes.

The perovskite nanocrystals (PeNCs) are emerging as a promising emitter for light-emitting diodes (LEDs) due to their excellent optical and electrical properties. However, the ultrafast growth of PeNCs often results in large sizes exceeding the Bohr diameter, leading to low exciton binding energy and susceptibility to nonradiative recombination, while small-sized PeNCs exhibit a large specific surface area, contributing to an increased defect density. Herein, Zn ions as a negative catalyst to realize quantum-confined FAPbBr PeNCs with high photoluminescence quantum yields (PL QY) over 90%.

Synergistic impact of psoriasis and hypertension on all-cause mortality risk: A prospective cohort study.

Background: The linkage between psoriasis and hypertension has been established through observational studies. Despite this, a comprehensive assessment of the combined effects of psoriasis and hypertension on all-cause mortality is lacking. The principal aim of the present study is to elucidate the synergistic impact of psoriasis and hypertension on mortality within a representative cohort of adults residing in the United States.