Testing the existence of waste Kuznets curve hypothesis in 45 emerging economies: Evidence from an e-waste panel data survey.

This study examines the Waste Kuznets Curve (WKC) hypothesis by integrating it with the Tapio decoupling model to explore the relationship between economic development and e-waste imports in 45 emerging economies from 2002 to 2022. The empirical results show that (1) the relationship between economic growth and e-waste imports exhibits an inverted U-shaped curve, with decoupling achieved when GDP per capita exceeds the WKC turning point of $10,755.23; (2) Emerging economies are categorized into six quadrants based on their e-waste decoupling status: high-income non-decoupling, low-income non-decoupling, low-income relative decoupling, high-income relative decoupling, low-income absolute decoupling, and high-income absolute decoupling; (3) Most emerging economies remain in low-income non-decoupling state, with only a few countries like China and Poland achieving high-income absolute decoupling.

Effectiveness and Safety of Micro-Plasma Radiofrequency Treatment Combined With Autologous Chyle Fat Grafting Treatment for Hypertrophic Scars: A Retrospective Study.

Background: Hypertrophic scar (HS) is a fibroproliferative disorder resulting from abnormal healing of skin tissue after injury. Although various therapies are currently employed in clinical to treat HSs, there is no widely accepted standard therapy. Micro-plasma radiofrequency (MPR) and autologous chyle fat grafting are emerging treatments for this condition, and they have demonstrated promising therapeutic outcomes in clinical applications.

Adipocyte-derived ferroptotic signaling mitigates obesity.

Ferroptosis is characterized as an iron-dependent and lipophilic form of cell death. However, it remains unclear what role ferroptosis has in adipose tissue function and activity. Here, we find a lower ferroptotic signature in the adipose tissue of individuals and mice with obesity.

BODIPY-Based Ratiometric Fluorescent Probe for Sensing Peroxynitrite in Inflammatory Cells and Tissues.

Peroxynitrite (ONOO) plays an important role in many physiological and pathological processes. Excessive ONOO in cells leads to oxidative stress and inflammation. However, precise monitoring of ONOO levels in specific organelles (e.

Alkaloids and Iridoids from Phlogacanthus curviflorus.

Four unreported pyridine alkaloids, curviflorines A-D (1-4), two undescribed iridoids, curviridoids A and B (5 & 6), and one known iridoid glycoside (7), were isolated from the twigs and leaves of Phlogacanthus curviflorus. The structures of these compounds were established by detailed interpretation of MS and NMR data, with the absolute configurations being assigned via comparison of experimental and calculated electronic circular dichroism spectra. Notably, it is the first report of alkaloidal constituents (1-4) from the genus Phlogacanthus.

Emerging and characterization of a novel fowl adenovirus 4 strain with open reading frame 19 (ORF19) in diseased chickens from China.

The highly virulent genotype fowl adenovirus 4 (FAdV-4), associated with severe hydropericardium hepatitis syndrome (HHS) in poultry from China, is characterized by a large deletion of 1966 bp (1966-del), including losses of ORF19 and ORF27. However, how this virus originated remains unclear. In this study, a novel FAdV-4 strain, HNU-XXY-2019, from diseased chickens, which has a genome size of 45669 bp and is approximately 1966 bp longer than the known FAdV-4 genome from China, was isolated and characterized.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis.

The induction of adipose thermogenesis plays a critical role in maintaining body temperature and improving metabolic homeostasis to combat obesity. β3-adrenoceptor (β3-AR) is widely recognized as a canonical β-adrenergic G-protein-coupled receptor (GPCR) that plays a crucial role in mediating adipose thermogenesis in mice. Nonetheless, the limited expression of β3-AR in human adipocytes restricts its clinical application.

New insights into the efficient secretion of foreign protein in Bacillus subtilis via Ribo-seq and RNA-seq integrative analyses.

Background: As an important prokaryotic model organism, Bacillus subtilis has been widely used in the industrial production of a variety of target products. The efficient secretion of target products has always been the main purpose of industrial microbial technology. The modification of gene regulatory networks is an important technical means to construct a factory of microbial cells that efficiently secretes target products.

Mapping rapeseed () aboveground biomass in different periods using optical and phenotypic metrics derived from UAV hyperspectral and RGB imagery.

Aboveground biomass (AGB) is a key indicator of crop nutrition and growth status. Accurately and timely obtaining biomass information is essential for crop yield prediction in precision management systems. Remote sensing methods play a key role in monitoring crop biomass.

The asymptomatic tuberculosis proportion among the elderly population: a systematic review and meta-analysis.

Background: The elderly population is a high-risk group for tuberculosis, and increasing evidence demonstrates a comparatively high proportion of asymptomatic tuberculosis in this group. This study aimed to determine the proportion of asymptomatic tuberculosis among patients with active tuberculosis through active case finding in the elderly population.

Materials And Methods: We searched for relevant articles published from the establishment of each database to December 31, 2023 in Web of Science, PubMed, VIP database, Chinese National Knowledge Infrastructure, and Wanfang database.

Ingenane diterpenoids with anti-inflammatory activity from Euphorbia antiquorum.

The Euphorbia plants are famous for their diterpenoid constituents with diverse structures and broad biological activities. Herein, the discovery of 15 ingenane diterpenoids including 10 previously unreported ones (1-10) from Euphorbia antiquorum was presented. Structures of the undescribed compounds were established via detailed spectroscopic analyses.

Wolfberry Honey and Its Extract Alleviate Dextran Sodium Sulfate-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Reducing Oxidative Stress and Inflammation.

Inflammatory bowel disease (IBD) is a chronic condition characterized by gut inflammation causing persistent diarrhea and abdominal pain. Despite the nutritional benefits of wolfberry honey (from Lycium barbarum L.), its potential to alleviate IBD remains underexplored.

Determination of Lactoferrin Using High-Frequency Piezoelectric Quartz Aptamer Biosensor Based on Molecular Bond Rupture.

In this study, an aptamer biosensor for detecting lactoferrin (LF) was developed using piezoelectric quartz-induced bond rupture sensing technology. The thiol-modified aptamer I was immobilized on the gold electrode surface of the quartz crystal microbalance (QCM) through an Au-S bond to specifically bind LF. It was then combined with aptamer-magnetic beads to amplify the mass signal.

Tolerability, safety, and pharmacokinetics of GR1603 injection in healthy subjects: a randomized, double-blind, placebo-controlled single-dose escalation clinical trial.

Background: GR1603 is a monoclonal antibody targeting the type I interferon receptor. The aim of this study was to evaluate the safety, tolerability, pharmacokinetics, immunogenicity and pharmacodynamics of GR1603 in healthy volunteers.

Methods: Healthy adults (≥18 years old) were enrolled in a placebo control, dose-escalation Phase I clinical trial receiving a single injectable dose of GR1603.

Gut microbiota of patients insusceptible to olanzapine-induced fatty liver disease relieves hepatic steatosis in rat.

Olanzapine-induced fatty liver disease continues to pose vital therapeutic challenges in the treatment of psychiatric disorders. In addition, we observed that some patients were less prone to hepatic steatosis induced by olanzapine. Therefore, we aimed to investigate the role and the underlying mechanism of the intestinal flora in olanzapine-mediated hepatic side effects and explore the possible countermeasures.

A Retrospective Data Audit of Outcome of Moderate and Severe Covid-19 Patients Who Had Received MP and Dex: A Single Center Study.

Purpose: To evaluate the necessity of the application of glucocorticoid (GC) in moderate COVID-19 patients, and which is the optimal choice between methylprednisolone (MP) and dexamethasone (DEX) in the clinical use of GC in different types of COVID-19 patients.

Patients And Methods: The study included patients with COVID-19 in Shanxi, China, from December 18, 2022, to March 1, 2023. The main clinical outcomes were 30-day mortality, disease exacerbations, and hospitalization days.

Research advancements in the association between prevalent trace metals and connective tissue diseases.

Connective tissue diseases (CTD) encompass a spectrum of autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), inflammatory myopathy (IIM), systemic sclerosis (SSc), among others. Recent research has highlighted the significant role of trace metals in the pathogenesis of connective tissue diseases. This article provides an overview of recent advancements in understanding the correlation between common trace metals such as iron, copper, zinc and CTD, aiming to offer novel insights for the diagnosis and treatment of these conditions.

Effect of black highland barley polysaccharides and low frequency-static magnetic field on casein-based coacervates: Formation, characterization, and probiotic encapsulation capacity.

To evaluate the combination effects of highland barley polysaccharides (HBP) and low-frequency static magnetic field (LF-SMF) treatment on the structure and properties of acid-induced casein (CS) coacervates, this study conducted a comprehensive investigation at various stages- before, during, and after coacervation-for the first time. Compared with native CS, adding HBP caused CS to denature owing to hydrophobic and electrostatic interactions, and LF-SMF treatment further promoted these changes. During the acidification (pH 7.

Effects of high-intensity interval training on cardiorespiratory function in coronary artery disease: An overview of systematic reviews.

Background: Exercise-based cardiac rehabilitation has been identified as a crucial component in mitigating all-cause mortality among individuals diagnosed with coronary artery disease (CAD). Nevertheless, the optimal exercise prescription remains elusive.

Objective: The purpose of this overview is to conduct a systematic evaluation and synthesis of the evidence derived from systematic reviews/meta-analyses (SRs/MAs) regarding the effects on cardiorespiratory fitness and safety of high-intensity interval training (HIIT) compared to moderate-intensity continuous training (MICT) for CAD.

Transmission line foreign object segmentation based on RB-UNet algorithm.

Background: The identification of foreign objects on transmission lines is crucial for their normal operation. There are risks and difficulties associated with identifying foreign objects on transmission lines due to their scattered distribution and elevated height.

Methods: The dataset for this paper consists of search material from the web, including bird nests, kites, balloons, and rubbish, which are common foreign objects found on top of transmission lines, totaling 400 instances.

Exploratory Development of a Prognostic Model for Coronary Artery Disease Utilizing CT-FFR Derived Functional Duke Jeopardy Score.

Rationale And Objectives: To explore the prognostic value of the functional Duke Jeopardy Score based on CT-FFR(fDJS) in assessing major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD).

Materials And Methods: A total of 894 patients with stable CAD with stenosis ranging from 30% to 90%, who underwent CCTA were included in the study. Follow-up was performed to record MACE.

Ampelopsis japonica enhances the effect of radiotherapy in non-small cell lung cancer.

Background: Radiotherapy is widely used in the clinical treatment of non-small cell lung cancer (NSCLC); however, its effectiveness often proves unsatisfactory. Ampelopsis japonica (AJ) is a traditional Chinese herb with anti-inflammatory and anticancer activities. However, whether AJ could enhance the effect of radiotherapy in NSCLC needs to be further explored.

Spatial transcriptomics in focal cortical dysplasia type IIb.

Focal cortical dysplasia (FCD) type IIb (FCD IIb) is an epileptogenic malformation of the neocortex that is characterized by cortical dyslamination, dysmorphic neurons (DNs) and balloon cells (BCs). Approximately 30-60% of lesions are associated with brain somatic mutations in the mTOR pathway. Herein, we investigated the transcriptional changes around the DNs and BCs regions in freshly frozen brain samples from three patients with FCD IIb by using spatial transcriptomics.