Publications by authors named "Wu Meng-Chao"
Objective: To evaluate the efficacy and safety of Cidan Capsule combined with adjuvant transarterial chemoembolization (TACE) in patients with a high risk of early recurrence after curative resection of hepatocellular carcinoma (HCC).
Methods: A multicenter, randomized controlled trial was conducted in patients with high-risk recurrence factors after curative resection of HCC from 9 medical centers between July 2014 and July 2018. Totally 249 patients were randomly assigned to TACE with or without Cidan Capsule administration groups by stratified block in a 1:1 ratio.
Non-alcoholic fatty liver disease (NAFLD) is emerging as an epidemic risk factor for hepatocellular carcinoma (HCC). The progression of NAFLD to HCC is closely associated with paracrine communication among hepatic cells. Vascular endothelial growth factor A (VEGFA) plays a key role in NAFLD and HCC; however, the cellular communication of VEGFA in the pathological transition from NAFLD to HCC remains unclear.
View Article and Find Full Text PDFA new staging system for hepatocellular carcinoma associated with portal vein tumor thrombus.
Hepatobiliary Surg Nutr
December 2021
Article Synopsis
- A new staging system for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) was created by improving upon existing classifications, incorporating factors like liver function and tumor resectability.
- The research involved a training cohort of 2,179 patients and a validation cohort of 1,550 patients from major liver centers in China, demonstrating the system's effectiveness in predicting overall survival based on identified clinical factors.
- The new staging system showed strong ability to classify patients into distinct stages, significantly impacting median overall survival rates, thus serving as a valuable supplement to current HCC staging systems.
Background: Microvascular invasion (MVI) is a risk factor of post-hepatectomy tumor recurrence for hepatocellular carcinoma (HCC). The patterns, treatments, and prognosis have not been documented in HCC patients with MVI.
Methods: A multicenter database of patients with HCC and MVI following resection was analyzed.
Mesoporous Silica Nanoparticles for Potential Immunotherapy of Hepatocellular Carcinoma.
Front Bioeng Biotechnol
October 2021
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death worldwide, which lacks effective inhibition of progression and metastasis in the advanced clinical stage. Mesoporous silica nanoparticle (MSN)-based cytotoxic or immunoregulatory drug-loading strategies have attracted widespread attention in the recent years. As a representative of mesoporous biomaterials, MSNs have good biological characteristics and immune activation potential and can cooperate with adjuvants against HCC.
View Article and Find Full Text PDFBackground: Microvascular invasion (MVI) adversely affects long-term survival in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). This study aimed to examine the association between preoperative type 2 diabetes mellitus (T2DM) with incidences of MVI and prognosis in HBV-related HCC after liver resection (LR).
Material And Methods: Data of HBV-related HCC patients who underwent LR as an initial therapy from four hospitals in China were retrospectively collected.
Article Synopsis
- The study investigates the relationship between preoperative international normalized ratio (INR) levels and the occurrence of portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) patients, highlighting its implications for patient outcomes.
- It included 2,207 HCC patients, noting that those in the Low INR group had a higher incidence and more severe forms of PVTT compared to Normal and High INR groups.
- The findings show that patients with Low INR experienced significantly worse recurrence-free survival (RFS) and overall survival (OS) rates post-liver resection, suggesting that INR levels could be a critical factor for predicting prognosis in these patients.
Portal vein tumor thrombus (PVTT) is one of the most serious forms of hepatocellular carcinoma (HCC) vessel metastasis and has a poor survival rate. However, the molecular mechanism of PVTT has not yet been elucidated. In this study, the molecular mechanism of AXL expressed in tumor-derived endothelial cells (TECs) in vessel metastasis was investigated.
View Article and Find Full Text PDFBackground: Microvascular invasion (MVI) is a risk factor for postoperative survival outcomes for hepatocellular carcinoma (HCC) after liver resection (LR). This study aims to investigate the actual long-term survival and its associated prognostic factors after LR for HCC patients with MVI.
Methods: This study was conducted on HCC patients with MVI who underwent LR from January 2009 to December 2012 at five major hospitals in China.
Article Synopsis
- The study analyzed the long-term survival of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT), focusing on the influence of splenomegaly and splenectomy on outcomes after liver resection.
- Out of 716 HCC patients, 140 had splenomegaly, and the study found that splenomegaly was linked to poorer overall and recurrence-free survival compared to those without it.
- Patients who underwent splenectomy for splenomegaly showed significantly better survival rates than those who did not, highlighting the potential benefits of splenectomy in improving long-term outcomes for these patients.
Background: Surgical resection of huge hepatocellular carcinoma (HCC, ≥ 10 cm) is potentially curative. More adjuvant treatments are needed to reduce relapses in these patients. We evaluated the influence of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) on the prognosis of huge HCC.
View Article and Find Full Text PDFArticle Synopsis
- Advanced hepatocellular carcinoma (HCC) treatment faces challenges, creating a need for effective alternative therapies; this study explores the use of HCC-derived extracellular vesicles (EVs) as a delivery system for targeted treatment through nanocatalysts.* -
- The unique design of the nanocarrier, referred to as GOD-ESIONs@EVs (GE@EVs), enhances the uptake of therapeutic agents in HCC cells via RGD-targeting, allowing for efficient tumor suppression and triggering cell death.* -
- In addition to their therapeutic role, these engineered EVs show potential as contrast agents for magnetic resonance imaging, suggesting broad applications in biomedicine beyond just cancer treatment.*
A new classification for hepatocellular carcinoma with hepatic vein tumor thrombus.
Hepatobiliary Surg Nutr
December 2020
Background: Hepatic vein tumor thrombus (HVTT) is a significant poor risk factor for survival outcomes in hepatocellular carcinoma (HCC) patients. Currently, the widely used international staging systems for HCC are not refined enough to evaluate prognosis for these patients. A new classification for macroscopic HVTT was established, aiming to better predict prognosis.
View Article and Find Full Text PDFBackground: Krüppel-like factor 8 (KLF8), a cancer-promoting factor that regulates critical gene transcription and cellular cancer-related events, has been implicated in tumor development and progression. However, the functional role of KLF8 in the pathogenesis of hepatocellular carcinoma (HCC) remains largely unknown.
Methods: The gene expression patterns and genome-wide regulatory profiles of HCC cells after KLF8 knockout were analyzed by using RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) of histone H3 lysine 27 acetylation (H3K27ac) combined with bioinformatics analysis.
Background: With an increase in life expectancy and improvement of surgical safety, more elderly patients with hepatocellular carcinoma (HCC), even with large tumors, are now considered for hepatectomy. This study aimed to clarify the impact of age on short- and long-term outcomes after major hepatectomy (≥3 segments) for large HCC (≥5 cm).
Patients And Methods: Using a multicenter database, patients who underwent curative-intent major hepatectomy for large HCC between 2006 and 2016 were identified.
Article Synopsis
- The study investigates how the surgical margin impacts the prognosis of patients with early solitary hepatocellular carcinoma (HCC) and finds that a margin of more than 2 mm leads to better survival outcomes.
- Patients with a surgical margin greater than 2 mm exhibited higher 5-year recurrence-free survival (RFS) and overall survival (OS) rates, both before and after adjusting for biases with propensity score matching.
- Furthermore, the research highlights that wide-margin resection particularly benefits patients with microvascular invasion and those without liver cirrhosis, suggesting the need for individualized surgical strategies based on tumor and liver factors.
Article Synopsis
- - The study analyzed data from 894 patients who underwent liver resection for HBV-associated hepatocellular carcinoma (HCC) to explore the factors affecting early (≤2 years) and late (>2 years) recurrence after surgery.
- - Key findings indicated that 36% of patients had early recurrence while 31.5% had late recurrence, with high preoperative HBV-DNA levels linked to both types of recurrence, and early recurrence correlated with worse survival outcomes.
- - The research concluded that different risk factors are involved in early and late recurrences, but high HBV-DNA levels were a significant risk for both; early recurrence led to a lower chance of receiving further curative treatment and poorer median survival post
Background: To develop an easy-to-use model to predict the probability of perioperative blood transfusion (PBT) in patients undergoing liver resection for hepatocellular carcinoma (HCC).
Method: 878 patients from Eastern Hepatobiliary Surgery Hospital of Shanghai were enrolled in the training cohort, while 691 patients from Tongji Hospital of Wuhan and 364 patients from two hospitals from Europe and America served as the Eastern and Western external validation cohorts, respectively. Independent predictors of PBT were identified and used for the nomogram construction.
Background: Iatrogenic biliary injury (IBI) following laparoscopic cholecystectomy (LC) is the most serious iatrogenic complications. Little is known whether LC-IBI would lead to surgeon's severe mental distress (SMD).
Methods: A cross-sectional survey in the form of electronic questionnaire was conducted among Chinese general surgeons who have caused LC-IBI.
Background: Aging of the population and prolonged life expectancy have significantly increased the number of elderly patients undergoing hepatectomy for hepatocellular carcinoma (HCC). However, potential benefits, especially long-term oncologic outcomes of hepatectomy for elderly patients with HCC remain unclear.
Method: Patients treated with curative-intent hepatectomy for HCC in 8 Chinese hospitals were enrolled.
Article Synopsis
- Repeat hepatectomy is a viable option for treating intrahepatic recurrence of hepatocellular carcinoma, but the survival benefits are not well understood.
- A study analyzed patients who underwent repeat hepatectomy, distinguishing between early and late recurrences to assess long-term outcomes.
- Results showed that patients with early recurrence had significantly lower overall and disease-free survival rates compared to those with late recurrence, indicating that early recurrence is linked to poorer prognosis.
Background: Large, multinodular (> 3 nodules and/or > 3 cm) hepatocellular carcinoma (HCC) is not an indication for liver resection based on the Barcelona Clinic Liver Cancer (BCLC) staging classification. We hypothesize that microvascular invasion (MVI) is a strong indication for surgery in these patients.
Methods: Between December 2009 and December 2010, a retrospective cohort of the patients with BCLC intermediate stage HCC undergoing surgical resection at Eastern Hepatobiliary Surgery Hospital was analyzed.
Background: The aim of this study was to evaluate the effect of portal vein tumor thrombus (PVTT) on the prognosis of patients undergoing liver resection (LR) for primary liver malignancies (PLC).
Methods: The recurrence-free survival (RFS) and overall survival (OS) for patients undergoing LR with and without PVTT for three primary liver malignancies, including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and hepato-cholangio carcinoma (CHC) were compared using the Kaplan-Meier method and Cox regression analysis.
Results: In total, 3775 patients with PLC who underwent LR were included in this study.
Background: To identify the impact of tumor number on Barcelona Clinic Liver Cancer (BCLC) early-stage hepatocellular carcinoma (HCC) and the impact of microvascular invasion (MVI) on multinodular HCC (MHCC).
Methods: We retrospectively analyzed 1,548 patients who had early-stage HCC [solitary HCC (SHCC, n=1,481) and MHCC (n=67)], according to the BCLC classification, after curative resection. Recurrence-free survival (RFS) and overall survival (OS) were compared.
Background: A clear definition of "early recurrence" after hepatocellular carcinoma (HCC) resection is still lacking. This study aimed to determine the optimal cutoff between early and late HCC recurrence, and develop nomograms for pre- and postoperative prediction of early recurrence.
Methods: Patients undergoing HCC resection were identified from a multi-institutional Chinese database.