Modulating the properties of g-C3N4 through two-step annealing and ionic-liquid gating.

We reported a novel strategy by the combination of two-step annealing treatment and ionic-liquid gating technology for effectively regulating the properties of g-C3N4, especially largely reducing the recombination rate of the electron-hole pairs, with evidenced by the remarkable reduction of photoluminescence (PL) intensity. Firstly, graphitic carbon nitrides with typical layered structure were obtained by annealing melamine with temperature above 500°C. Further annealing at 600°C with much longer time (from 2 hours to 12 hours) were found to effectively reduce the imperfections or defects, and thus the PL intensity (49% reduction).

Tire Wear Particles Exposure Enhances Denitrification in Soil by Enriching Labile DOM and Shaping the Microbial Community.

Tire wear particles (TWP) are emerging contaminants in the soil environment due to their widespread occurrence and potential threat to soil health. However, their impacts on soil biogeochemical processes remain unclear. Here, we investigated the effects of TWP at various doses and their leachate on soil respiration and denitrification using a robotized continuous-flow incubation system in upland soil.

Depth weakens effects of long-term fertilization on dissolved organic matter chemodiversity in paddy soils.

Dissolved organic matter (DOM) is pivotal for soil biogeochemical processes, soil fertility, and ecosystem stability. While numerous studies have investigated the impact of fertilization practices on DOM content along soil profiles, variations in DOM chemodiversity and the underlying factors across soil profiles under long-term fertilization regimes remain unclear. Using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) and high-throughput sequencing, this study investigated DOM composition characteristics and microbial community compositions across different soil layers (0-20, 20-40, 40-60, and 60-100 cm) in paddy soil under different long-term fertilization treatments, including Control (no fertilizer), NPK (mineral NPK fertilizer), NPKHS (NPK fertilizer with half straw return), and NPKS (NPK fertilizer with full straw return).

Design of a pseudo-color-assisted biocompatible supramolecular sensing probe for "lighting up" endogenous salicylic acid in plants.

The widely recognized phytohormone, salicylic acid (SA), serves not only as an exogenous additive for fruits and vegetables but, more crucially, as an in vivo regulator of the entire plant growth process. Consequently, it is essential to achieve both in vitro detection and in vivo imaging analysis of the plant hormone SA. In this study, a biocompatible supramolecular probe was crafted using a "label-free" SA aptamer as the host for an aggregation-induced emission (AIE) organic small molecule.

Tendon Groove Technique: A Double-Bundle Footprint Technique for Anterior Cruciate Ligament Reconstruction.

Double-bundle (DB) anterior cruciate ligament (ACL) reconstruction has biomechanical advantages over single-bundle reconstruction. However, most studies perform the DB reconstruction with 2 femoral tunnels, which fails to provide an entire femoral footprint for ACL reconstruction. In this study, we describe a femoral double-bundle footprint technique for ACL reconstruction, named the tendon groove technique.

Increased Lateral Femoral Condyle Ratio Is Associated With a Greater Risk of Anterior Cruciate Ligament Injury and Concomitant Anterolateral Ligament and Meniscus Injuries.

Purpose: To investigate whether lateral femoral condyle ratio (LFCR) and lateral femoral condyle index (LFCI) were associated with a greater risk of anterior cruciate ligament (ACL) injury and concomitant injuries.

Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered on PROSPERO. PubMed, Web of Science, Embase, and the Cochrane Library were searched from inception to April 1, 2024.

An injectable tricalcium silicate/α-tricalcium phosphate/hydroxypropyl methylcellulose biocomposite with improved physicochemical properties and osteoinductive activity for endodontic application.

Tricalcium silicate (TCS)-based bioactive cements have attracted great attention for various endodontic applications owing to their hydraulic property, sealing ability and biological properties. Nevertheless, poor handling property and anti-washout ability are the main challenges for traditional TCS-based cements and their osteoinductive capacity needs enhance for accelerated pulpal and periapical tissue repair/regeneration. Herein, we developed an injectable TCS/α-tricalcium phosphate (α-TCP)/hydroxypropyl methylcellulose (HPMC) biocomposite with improved physicochemical properties and osteoinductive ability via the incorporation of α-TCP/HPMC.

Prevalence and drug resistance analysis of hepatitis C virus genotypes in Heilongjiang, China.

Hepatitis C still poses a threat to public safety, and there are few reports of hepatitis C virus (HCV) in Heilongjiang Province. Therefore, we aimed to study the epidemiology and resistance-associated substitutions (RASs) of HCV in Heilongjiang and explore the efficacy of treatment. 7019 specimens from Heilongjiang Province were subjected to the genotype identification.

Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage.

Background And Purpose: The field of hydrogen medicine has garnered extensive attention since Professor Ohsawa established that low concentrations of hydrogen (2%-4%) exert antioxidant effects. The present study aimed to evaluate the therapeutic effect of molecular hydrogen in a CUMS rat model.

Methods: A total of 40 SD rats were randomly divided into a control group, a model group, a hydrogen group, and a positive drug group.

Redox-sensitive epigenetic activation of SUV39H1 contributes to liver ischemia-reperfusion injury.

Liver ischemia-reperfusion (I/R) injury is a clinically relevant pathophysiological process that determines the effectiveness of life-saving liver transplantation, to which aberrant ROS accumulation plays a key role. In the present study we investigated the role of SUV39H1, a lysine methyltransferases, in this process focusing on regulatory mechanism and translational potential. We report that SUV39H1 expression was up-regulated in the liver tissues of mice subjected to ischemia-reperfusion and in hepatocytes exposed to hypoxia-reoxygenation (H/R) in a redox-sensitive manner.

Quantitative Unraveling of Exsolved Heteroboundaries for High-Temperature Electrocatalysis.

The application of perovskite oxide for high-temperature electrocatalysis is hindered by its limited activity. Exsolution is a smart strategy that allows the enrichment of the perovskite's surface with highly reactive phases, yielding heteroboundaries. However, the identification of the exact catalytic role of this complex architecture is still elusive.

Development of Human Monoclonal Antibodies With Broad Reactivity for Rabies Postexposure Prophylaxis.

Rabies is an acute lethal disease causing by the neurotropic virus rabies virus (RABV). Rabies immune globulin (RIG) as an indispensable component of rabies postexposure prophylaxis (PEP) always faces with great challenges in terms of costs, stability and safety. Our objective is to develop a novel and potential fully human monoclonal antibodies (mAbs) cocktail for the improvement of rabies PEP.

Clinical significance and expression of SLC35F6 in bladder urothelial carcinoma.

Background: SLC35F6 negatively regulates outer mitochondrial membrane permeability and positively regulates apoptotic signaling pathways and cell population proliferation. The biological function of SLC35F6 in bladder cancer (BC) remains inadequately established. This study evaluates the expression and clinical significance of SLC35F6 in BC, assesses its prognostic value and explores its relationship with key immune-related molecules in the tumor microenvironment.

[Electroacupuncture reduces neuronal apoptosis in rats with spinal cord injury by regulating GSK-3β expression and its phosphorylation].

Objectives: To observe the effect of electroacupuncture (EA) stimulation of "Dazhui"(GV14) and "Mingmen" (GV4) of the Governor Vessel (GV) on the apoptosis of neurons in rats with spinal cord injury (SCI) by regulating the expression of glycogen synthase kinase-3β (GSK-3β) protein and its phosphorylation level, so as to reveal partial mechanism for the treatment of SCI with EA of GV.

Methods: A total of 45 male SD rats were randomly divided into sham-operation, model and EA groups, 15 rats in each group. The SCI model was established by using the modified Allen's percussion device.

A Multi-Functional Cascade Nanoreactor for Remodeling Tumor Microenvironment to Realize Mitochondria Dysfunction via ROS/Zn Ions Overload.

Combining chemo/photodynamic therapy (CDT/PDT) to generate highly harmful reactive oxygen species and cause mitochondria dysfunction is considered a potential strategy to improve the efficiency of anticancer treatment. However, within tumor, the relatively deficient concentration of HO, hypoxic microenvironment, and overexpressed reduced glutathione (GSH) seriously suppress the efficacy of dynamic therapy. Herein, a multi-functional cascade nanoreactor, bovine serum albumin modified ZnO@CeO-ICG, is reported for remodeling tumor microenvironment (TME) to boost dynamic therapy and realize mitochondria dysfunction via reactive oxygen species (ROS) storm/Zn ions overload.

Development of a core predictor set of weaning in critically ill patients: a Delphi-based study protocol.

Introduction: Prolonged mechanical ventilation in intensive care units (ICUs) leads to increased morbidity, higher mortality rates, and elevated healthcare costs. Predicting successful weaning from mechanical ventilation with accuracy is essential for optimizing resource use and improving patient outcomes. The International Classification of Functioning, Disability and Health (ICF) framework offers a holistic perspective on health conditions and can be adapted to identify key predictors of weaning readiness.

Interaction between Dietary Magnesium Intake and Genetic Risk Score on the Risk of Gestational Diabetes.

Scope: We aim to assess the interaction between genetic risk and magnesium (Mg) intake during pregnancy on the development of gestational diabetes mellitus (GDM).

Methods And Results: Three thousand ninety-six pregnant women from Tongji Maternal and Child Health Cohort are involved in our study. One hundred twelve susceptibility genetic variants of diabetes are selected and genotyped through Asian Screening Array bead chip.

In-Device Ballistic-Electron-Emission Spectroscopy for Accurately In Situ Mapping Energy Level Alignment at Metal-Organic Semiconductors Interface.

Energy level alignment at metal/organic semiconductors (OSCs) interface governs electronic processes in organic electronics devices, making its precise determination essential for understanding carrier transport behaviors and optimizing device performance. However, it is proven that accurately characterizing the energy barrier at metal/OSC interface under operational conditions remains challenging due to the technical limitations of traditional methods. Herein, through integrating highly-improved device constructions with an ingenious derivative-assisted data processing method, this study demonstrates an in-device ballistic-electron-emission spectroscopy using hot-electron transistors to accurately characterize the energy barrier at metal/OSC interface under in-operando conditions.

Low-Intensity Focused Ultrasound-Responsive Phase-Transitional Liposomes Loaded with STING Agonist Enhances Immune Activation for Breast Cancer Immunotherapy.

Pharmacologically targeting the STING pathway offers a novel approach to cancer immunotherapy. However, small-molecule STING agonists face challenges such as poor tumor accumulation, rapid clearance, and short-lived effects within the tumor microenvironment, thus limiting their therapeutic potential. To address the challenges of poor specificity and inadequate targeting of STING in breast cancer treatment, herein, we report the design and development of a targeted liposomal delivery system modified with the tumor-targeting peptide iRGD (iRGD-STING-PFP@liposomes).