Structural characterization of polysaccharides from three seaweed species and their hypoglycemic and hypolipidemic activities in type 2 diabetic rats.

Three algal polysaccharides (APs) were acquired from Scagassum (SCP), Sargassum fusiforme(Harv.) Setch. (SFP) and Macrocystis pyrifera(L.

Antiviral Adaptor MAVS Promotes Murine Lupus With a B Cell Autonomous Role.

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by increased production of autoantibodies, which commonly target nuclear antigens, and concomitant deposition of immune complexes that cause inflammation in tissues. SLE is often associated with increased systemic expression of type I interferons, in some cases due to dysregulation in nucleic acid-sensing innate pathways. There is strong genetic evidence for a link between cytoplasmic RNA sensing pathways (RIG-I/MDA5) and SLE, both in human patients and murine models, however questions still remain regarding pathway initiation, cell types involved and downstream effects.

Effects of β‑hydroxybutyric acid and ghrelin on the motility and inflammation of gastric antral smooth muscle cells involving the regulation of growth hormone secretagogue receptor.

Ghrelin is an orexigenic hormone that is produced by gastric cells. Ghrelin stimulates food intake and increases gastric movement. In rat model, injected β‑hydroxybutyric acid (β‑HB) leads to a decrease in body weight.

Paris saponin VII extracted from Trillium tschonoskii induces autophagy and apoptosis in NSCLC cells.

Ethnopharmacological Relevance: Trillium tschonoskii Maxim, a perennial herb of the Trilliaceae, has been widely used to treat inflammation, hypertension and cancer. We investigated Paris saponin VII's (PS VII), isolated from Trillium tschonoskii Maxim, function in mediating autophagy and apoptosis in NSCLC cells.

Materials And Methods: We treated various NSCLC cells with different concentrations of PS Ⅶ and then measure the cell apoptosis by using flow cytometry assays and western blot.

Plasma metabolite profiling reveals potential biomarkers of giant cell tumor of bone by using NMR-based metabolic profiles: A cross-sectional study.

Giant cell tumor (GCT) of bone is a locally aggressive bone tumor, which accounts for 4% to 5% of all primary bone tumors. At present, the early diagnosis and postoperative recurrence monitoring are still more difficult due to the lack of effective biomarkers in GCT. As an effective tool, metabolomics has played an essential role in the biomarkers research of many tumors.

Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients.

Background: Avoiding the phagocytosis by tumor-associated macrophages (TAMs) is necessary for the growth and metastasis of solid tumors. CD47 binds to the receptor signal-regulatory protein-α (SIRP-α) on the macrophages to avoid normal phagocytosis. In this study, we evaluated the expression and prognostic significance of CD47 and CD68-labeled TAMs in breast cancer solid tumors.

Influence of the application of irrigated water-soluble calcium fertilizer on wine grape properties.

The eastern foot of Helan mountain is a famous production area of high-end wine grapes in China. Excessive application of NPK fertilizer induced deficiency in trace elements, such as calcium, and seriously affected the properties of wine grapes. A vineyard in the eastern foot of Helan mountain was selected to investigate the influence of five different concentration treatments of 15 (T1), 30 (T2), 45 (T3), 60 (T4), and 75 (T5) kg·ha-1 of water-soluble calcium fertilizer (Ca(NO3)2·4H2O) application on grape calcium content, yield and fruit properties.

High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis.

CD47 functions as a dominant anti-engulfment signal on tumour cells and is overexpressed in various malignant tumours. However, the expression and functional significance of CD47 in triple-negative breast cancer (TNBC) is not completely understood. In the present study, CD47 was demonstrated to be overexpressed in TNBC solid tumours.

Reducing ammonia and greenhouse gas emission with adding high levels of superphosphate fertilizer during composting.

Previous studies revealed that superphosphate fertilizer (SSP) as an additive in compost can reduce the nitrogen loss and improve the effectiveness of phosphorus during composting. However, few studies have explored the influence of adding SSP with high levels on ammonia and greenhouse gas emission and the suitable amount for SSP addition according to a combined assessment of the composting process and product. The present study aimed to evaluate the impact of SSP with high additive amounts on NH, CO, CH, and NO emission and organic carbon loss.

Associations between serum IL-8 and knee symptoms, joint structures, and cartilage or bone biomarkers in patients with knee osteoarthritis.

Objective: The aim of this study was to investigate cross-sectional associations between serum levels of IL-8 and the above outcomes in patients with knee osteoarthritis (OA).

Methods: A total of 160 subjects with clinical knee OA were included. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and Lequesne index were used to assess the joint symptom.

Risk of breast cancer based on thermal tomography characteristics.

Background: There is no uniform standard for the diagnosis of breast lesions by thermal tomography (TT). This study aimed to widely analyse the predictive value of TT in patients with breast cancer and establish a uniform standard for the diagnosis of breast lesions.

Methods: We retrospectively analysed data from women who suffered from non-inflammatory unilateral single breast lesion and underwent TT from January 2014 to July 2016.

Responses of water quality and phytoplankton assemblages to remediation projects in two hypereutrophic tributaries of Chaohu Lake.

Water shortages and the presence of point and diffuse source pollution have caused a serious deterioration in water quality in two tributaries (the Tangxi River and Shiwuli River) of Chaohu Lake, China. To reduce nutrient pollution and suppress harmful algal blooms (HABs), hard engineering and ecological remediation projects were implemented. A post-project investigation from 2013 to 2016 was carried out to evaluate the outcome of the remediation projects by monitoring the seasonal and spatial variations in water quality and the phytoplankton community.

Immobilized lignin peroxidase on FeO@SiO@polydopamine nanoparticles for degradation of organic pollutants.

Lignin peroxidase (LiP) was obtained from Pichia methanolica through heterologous expression. LiP was extracted, purified, and immobilized on FeO@SiO@polydopamine (PDA) nanoparticles to acquire immobilized LiP. The optimal preparation conditions for immobilized LiP were investigated.

Sandwich-like SnS/Graphene/SnS with Expanded Interlayer Distance as High-Rate Lithium/Sodium-Ion Battery Anode Materials.

SnS materials have attracted broad attention in the field of electrochemical energy storage due to their layered structure with high specific capacity. However, the easy restacking property during charge/discharge cycling leads to electrode structure instability and a severe capacity decrease. In this paper, we report a simple one-step hydrothermal synthesis of SnS/graphene/SnS (SnS/rGO/SnS) composite with ultrathin SnS nanosheets covalently decorated on both sides of reduced graphene oxide sheets C-S bonds.

An Injectable, Bifunctional Hydrogel with Photothermal Effects for Tumor Therapy and Bone Regeneration.

Significant attention has been focused on bone tumor therapy recently. At present, the treatment in clinic typically requires surgical intervention. However, a few tumor cells remain around bone defects after surgery and subsequently proliferate within several days.

Allogeneic Hematopoietic Cell Transplant for HIV Patients with Hematologic Malignancies: The BMT CTN-0903/AMC-080 Trial.

We set out to assess feasibility and safety of allogeneic hematopoietic cell transplant in 17 persons with HIV in a phase II prospective multicenter trial. The primary endpoint was 100-day nonrelapse mortality (NRM). Patients had an 8/8 HLA-matched related or at least a 7/8 HLA-matched unrelated donor.

Biodegradation of aged polycyclic aromatic hydrocarbons in agricultural soil by Paracoccus sp. LXC combined with humic acid and spent mushroom substrate.

Paracoccus sp. LXC combined with humic acid (HA) and spent mushroom substrate (SMS) obtained from Auricularia auricular and Sarcomyxa edulis was tested for the remediation of agricultural soil contaminated with aged polycyclic aromatic hydrocarbons (PAHs). The biomass and diversity of bacteria and fungi and the soil enzyme activity were analyzed.

Genome-Wide Identification, Characterization, and Expression Analysis of the NAC Transcription Factor in .

The NAC (NAM, ATAF, and CUC) family is one of the largest families of plant-specific transcription factors. It is involved in many plant growth and development processes, as well as abiotic/biotic stress responses. So far, little is known about the NAC family in .

Cloning, expression and activity of ATP-binding protein in Bacillus thuringiensis toxicity modulation against Aedes aegypti.

Background: Bacillus thuringiensis israelensis (Bti) is a widely used mosquitocidal microbial pesticide due to its high toxicity. ATP-binding proteins (ABP) are prevalently detected in insects and are related to reaction against Bti toxins. However, the function of ABP in mosquito biocontrol is little known, especially in Aedes aegypti.

Plasma indoleamine 2,3-dioxygenase activity as a potential biomarker for early diagnosis of multidrug-resistant tuberculosis in tuberculosis patients.

Multidrug-resistant tuberculosis (MDR-TB) remains a challenge of global TB control, with difficulty in early detection of drug-sensitive tuberculosis (DS-TB). We investigate the diagnostic significance of IDO as a potential biomarker to discriminate MDR patients among the TB patients. Plasma indoleamine 2,3-dioxygenase (IDO) was measured by the ratio of kynurenine (Kyn) to tryptophan (Trp) concentrations, using high performance liquid chromatography-mass spectrometry (LC-MS/MS).

A tannin compound from blocks Wnt/β-catenin signaling pathway and induces apoptosis of colorectal cancer cells.

Background: , a popular Chinese herb, called DiYu, has been shown to inhibit the growth of many human cancer cell lines, including colorectal cancer cells. The aims of this study were to discover the active compound and molecular mechanism of against Wnt/β-catenin signaling pathway and develop Wnt inhibitors from natural products as anti-colorectal cancer agents.

Methods: 1,4,6-Tri--galloyl-β-d-glucopyranose (TGG) was obtained by the preparative HPLC.

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression.

Background: Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer. However, the mediators and mechanisms remain unclear.

Temporal ghost imaging for quantum device evaluation.

Ghost imaging (GI) can reconstruct the image of an object by measuring the correlation function of two beams, none of which carries the structure information of the object independently. This powerful technology makes it possible to obtain high-quality imaging of the object even in the presence of noise. Here, we introduce the GI method into quantum device evaluation in the time domain.