Analysis of garlic intake on atrophic gastritis risk in different infectious states of Helicobacter pylori in a case-control study.

In this case-control study, the main risk factors for atrophic gastritis (AG) were comprehensively analyzed in a real-world environment to identify potential risk factors associated with garlic intake and its effects on AG. Design Upper gastrointestinal endoscopy and pathological examination were performed as part of a gastric cancer screening and health check-up program. The detailed characteristics of both the case group and healthy control group were recorded and analyzed.

Moscatilin Induces Ferroptosis in Clear Cell Renal Cell Carcinoma via the JAK-STAT Signaling Pathway.

Moscatilin, a biphenyl compound derived from Dendrobium nobile, exhibits significant anti-tumor activity. However, the specific role of moscatilin in clear cell renal cell carcinoma (ccRCC) and its underlying molecular mechanisms have not been fully studied. This study aims to fill this gap by demonstrating through a series of experiments that moscatilin can effectively inhibit the proliferation and migration of ccRCC and induce its apoptosis process.

A new method for the quantification of polysaccharide structural domain: Rapid quantification of Rhamnogalacturonan-II by colorimetry.

Polysaccharides are important pharmacodynamically active components in traditional Chinese medicines and based on the type of monosaccharides and glycosidic linkages, they can be divided into different structural domains. Rhamnogalacturonan II (RG-II) is among the most complex and conserved structural domain within polysaccharides and possesses significant pharmacological effects. Nevertheless, there is no suitable method for quantifying homogeneous polysaccharides that contain the RG-II structural domain.

Total Sanghuangporus vaninii extract inhibits hepatocyte ferroptosis and intestinal microbiota disturbance to attenuate liver fibrosis in mice.

Ethnopharmacological Relevance: Sanghuangporus, the dried fruiting body of Sanghuangporus vaninii (Ljub) L.W.Zhou et Y.

OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity.

The 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway is a classical antiviral innate immune pathway. Upon sensing dsRNA, OAS produces 2',5'-oligoadenylate (2-5A) as a second messenger to activate RNase L. Whether 2-5A can be transported to extend the reach of innate immune signaling has not been established.

Impact of deep brain stimulation on cognitive impairment in Parkinson's disease: A retrospective longitudinal study.

Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for improving motor symptoms, non-motor symptoms, and quality of life (QOL) in patients with advanced Parkinson's disease (PD). However, its effects on patients with cognitive impairment (CI) remain controversial due to the unique challenges and risks posed by cognitive decline. This study aimed to evaluate the mid- to long-term impact of STN-DBS on motor function, non-motor symptoms, and QOL in PD patients with CI.

Radiofrequency Ablation Versus Thoracoscopic Sublobar Resection for the Treatment of Pulmonary Ground Glass Nodules: A Retrospective Observational Study.

Purpose: A variety of treatments options for pulmonary ground glass nodules (GGNs) are currently under investigation. This study aimed to retrospectively compare the safety and efficacy of two therapeutic concepts, radiofrequency ablation (RFA) and thoracoscopic sublobar resection, in the treatment of patients with resectable pulmonary GGNs.

Materials And Methods: This bi-center retrospective study included patients with resectable pulmonary GGNs who received either thoracoscopic sublobar resection or percutaneous computed tomography (CT)-guided RFA.

Assessing Plasma APLP1 for the Progression of Parkinson's Disease: Insights from HSPD and PPMI Cohorts.

Background: Amyloid precursor-like protein 1 (APLP1) is involved in pathological α-synuclein transmission, but its role in Parkinson's disease (PD) progression has not been explored.

Objective: This study investigates APLP1 as a potential predictor for motor and cognitive deterioration in PD.

Methods: Plasma APLP1 levels were measured in PD patients from the Huashan Hospital for Parkinson's Disease (HSPD) and Parkinson's Disease Progression Markers Initiative (PPMI) cohorts.

Molecular Network Characteristics and Drug Resistance Analysis Among Newly Diagnosed Persons Living with HIV-1 in Hefei, China (2017-2022).

Molecular transmission networks are being used with increasing frequency to study HIV-1 transmission patterns and to develop precise intervention strategies for high-risk populations. Here, we analyzed the molecular transmission networks of newly diagnosed patients with HIV-1 in Hefei City, Anhui Province, from 2017 to 2022. Of the 1,413 newly diagnosed HIV-1 sequences, the major genotypes in Hefei were CRF07_BC (600, 42.

Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment.

Inflammation and cartilage degeneration are critical challenges in osteoarthritis (OA) treatment. Achieving sustained drug efficacy while mitigating the adverse effects of inflammation and reactive oxygen species remains a significant challenge. This study synthesizes a gallic acid-magnesium (GA-Mg) metal-organic framework (MOF) as a drug carrier for puerarin (PA).

Self-Reported REM Sleep Behavior Disorder in Patients With Progressive Supranuclear Palsy: Clinical and F-Florzolotau PET Imaging Findings.

Background And Objectives: Rapid eye movement sleep behavior disorder (RBD) is increasingly recognized in patients with tauopathies, but its significance and underpinnings remain unclear. To address this gap, we investigated the prevalence of self-reported RBD in patients with progressive supranuclear palsy (PSP) and explored its clinical and imaging correlates using F-florzolotau PET imaging.

Methods: We consecutively enrolled patients meeting the 2017 Movement Disorder Society clinical criteria for PSP at a Chinese tertiary hospital between May 2019 and March 2022.

A systematic review of advances in preparation, structures, bioactivities, structural-property relationships, and applications of polysaccharides.

(Pers.) Fries is an edible fungus species belonging to the Polygonaceae family. Polysaccharides, the predominant bioactive compounds in , have been widely used due to its abundant nutritional and medicinal benefits.

Research Hotspots of Interferon Gamma in the Treatment of Lung Cancer: A Bibliometric Analysis Based on CiteSpace.

Interferon-gamma (IFN-γ) is an important cytokine associated with antitumor immunity and has been implicated in the pathogenesis and progression of lung cancer. Nevertheless, no bibliometric analyses have been published in this field to date, and thus we aim to address this gap in knowledge. A search of the Web of Science (WOS) for literature related to the treatment of lung cancer with IFN-γ was conducted from 2002 to 2024.

Rapid Cognitive Deterioration in Progressive Supranuclear Palsy: A 1-Year Follow-Up Study.

Background: Nowadays, cognitive impairment has been characterized as one of the most vital clinical symptoms in progressive supranuclear palsy (PSP).

Objectives: Based on a relatively large cohort, we aimed to show the cognitive deterioration in different PSP subtypes during 1-year follow-up and investigate potential contributors for disease prognosis.

Methods: One hundred seventeen patients from Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI) cohort underwent neuropsychological tests and 1-year follow-up, with 73 diagnosed as PSP-Richardson syndrome (PSP-RS) and 44 as PSP-non-RS.

Discovery of a Novel Public Antibody Lineage Correlated With Inactivated SARS-CoV-2 Vaccine and the Resultant Neutralization Activity.

While the SARS-CoV-2 vaccine offers 70%-95% protection effectiveness against Coronavirus disease 2019 (COVID-19), a portion of recipients do not produce adequate protective immune responses, particularly, neutralizing antibodies (nAbs). Previous studies of COVID-19 patients have identified several public antibody lineages, such as IGHV3-30, IGHV3-33, IGHV3-53, IGHV1-58, and IGHV1-24. However, it remains unclear how these public antibodies evolve during vaccination or whether there are any special antibody lineages correlated with SARS-CoV-2 vaccination.

F-Florzolotau PET Imaging Unveils Tau Pathology in Dementia with Lewy Bodies.

Background: Dementia with Lewy bodies (DLB) commonly exhibits a complex neuropathology, sharing characteristics with Alzheimer's disease (AD), including tau aggregates. However, studies using the F-AV-1451 tau tracer have shown inconsistent findings regarding both the extent and topographical distribution of tau pathology in DLB.

Objectives: Our aim was to elucidate the topographical patterns of tau deposition in DLB and to investigate the in vivo pathological distinction between DLB and AD in virtue of the F-Florzolotau positron emission tomography (PET) imaging.

Identification and validation of mRNA profiles linked to ATP- induced cell death represent a novel prognostic model for breast cancer.

Background: Cell death mechanisms are integral to the pathogenesis of breast cancer (BC), with ATP-induced cell death (AICD) attracting increasing attention due to its distinctive specificity and potential therapeutic applications.

Methods: This study employed genomic methodologies to investigate the correlation between drug sensitivity and types of AICD in BC. Initially, data from TCGA were utilized to construct a prognostic model and classification system for AICD.

Serum vitamin C levels and risk of osteoporosis: results from a cross-sectional study and Mendelian randomization analysis.

Background: The role of vitamin C as an antioxidant in guarding against osteoporosis in adults is still debated. This research employs both a cross-sectional study and a two-sample bidirectional Mendelian randomization (MR) analysis to explore how serum vitamin C levels correlate with the incidence of osteoporosis among adults.

Methods: In this study, we utilized data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2003-2006, and 2017-2018 to conduct both a cross-sectional analysis and MR to investigate the relationship between serum vitamin C levels and the risk of osteoporosis in adults.

A systematic review on polysaccharides from fermented Cordyceps sinensis: Advances in the preparation, structural characterization, bioactivities, structure-activity relationships.

Cordyceps sinensis (Berk.) Sacc. (Ophiocordyceps sinensis) is an edible and medicinal fungus used as a natural superior tonic.

Synchronous primary gastric diffuse large B-cell lymphoma and multiple lung primary adenocarcinoma with pulmonary cryptococosis: a case report and literature review.

Background: The coexistence of non-Hodgkin's lymphoma of the stomach and multiple primary lung adenocarcinomas with pulmonary cryptococcosis has rarely been reported.

Case Presentation: We herein present a 75-year-old man who was admitted to our hospital due to hematemesis. Gastroscopy and imaging revealed extensive stomach wall thickening and multiple lung lesions, including nodules and cavernous lesion.