Osteosarcoma is the most common primary bone malignancy in adolescents. Its high propensity to metastasize is the leading cause for treatment failure and poor prognosis. Although the research of osteosarcoma has greatly expanded in the past decades, the knowledge and new therapy strategies targeting metastatic progression remain sparse.
View Article and Find Full Text PDFPersisting declination of amphibians around the world has resulted in the public attaching importance to the conservation of their biodiversity. Genetic data can be greatly helpful in conservation planning and management, especially in species that are small in size and hard to observe. It is essential to perform genetic assessments for the conservation of , an endangered toad and receiving secondary protection on the list of state-protected wildlife in China.
View Article and Find Full Text PDFKidney renal papillary cell carcinoma (KIRP) is a type of low-grade malignant renal cell carcinoma. Huge challenges remain in the treatment of KIRP. Cell division cycle associated 3 (CDCA3) participates in human physiological and pathological processes.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
April 2022
The Chinese cordyceps, a parasitic fungus- larva complex, is a valuable biological resource endemic to the Tibetan Plateau. Protection of the Plateau environment and huge market demand make it necessary to culture this complex in an artificial system. A method for the large-scale artificial rearing of the insect host has been established.
View Article and Find Full Text PDFAllyl isothiocyanate (AITC) is a promising alternative to chemical fumigants, and mitochondrial dysfunction has been proposed to play a crucial role in its lethal mechanisms; however, the specific lethal mechanisms of AITC remain unknown. Four mitochondrial electron transport chain genes, nd5, nd6, cox1, and cox5, were selected from adult Sitophilus zeamais and processed with RNA interference experiments. Then, the biochemical and biophysical effects were compared between double-stranded RNA (dsRNA)-mediated insects and wild-type insects after AITC fumigation at the concentration of LC values.
View Article and Find Full Text PDFKidney Blood Press Res
February 2022
Background: The aim of the study was to screen biomarkers related to clear cell renal cell carcinoma (ccRCC) progression and prognosis.
Methods: 1,026 ccRCC-related genes were dug from 494 ccRCC samples in TCGA based on weighted gene co-expression network analysis, and 7 modules were identified. Afterward, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted on modules of interest.
Background: Cartilage damage is a common medical issue in clinical practice. Complete cartilage repair remains a significant challenge owing to the inferior quality of regenerative tissue. Safe and non-invasive magnetic therapy combined with tissue engineering to repair cartilage may be a promising breakthrough.
View Article and Find Full Text PDFBackground: Preschooler inactivity and insufficient motor development have serious long-term consequences. The Chinese Ministry of Education launched a nationwide football-focused pilot project aimed at kindergartens in 2019 and issued the policy "Notice on the Establishment of National Football Kindergartens" in 2020. However, the impact of fundamental movement skills (FMS) interventions on other aspects of child development is unclear.
View Article and Find Full Text PDFIn this paper we provide an overview of the rationale, methods, and preliminary results of the four Connectome Studies Related to Human Disease investigating mood and anxiety disorders. The first study, "Dimensional connectomics of anxious misery" (HCP-DAM), characterizes brain-symptom relations of a transdiagnostic sample of anxious misery disorders. The second study, "Human connectome Project for disordered emotional states" (HCP-DES), tests a hypothesis-driven model of brain circuit dysfunction in a sample of untreated young adults with symptoms of depression and anxiety.
View Article and Find Full Text PDFEvid Based Complement Alternat Med
October 2021
Objective: To explore the diagnostic value of FTO combined with CEA or CYFRA21-1 for nonsmall cell lung cancer (NSCLC) and to provide a theoretical basis for molecular diagnosis of NSCLC.
Methods: Totally, 60 patients with nonsmall cell lung cancer (NSCLC) treated in our hospital between Feb. 2018 and Feb.
Gray mold caused by is one of the most destructive postharvest decay of strawberry fruit. The present study aims to identify essential oils with antifungal activity against and the underlying mechanisms and their potential application in controlling postharvest decay. In the screening test, essential oils from (), (), and () exhibited maximum inhibition of mycelial growth.
View Article and Find Full Text PDFWilforine, a compound of sesquiterpene alkaloids isolated from Tripterygium wilfordii, exhibits excellent insecticidal activity against Mythimna separata. In order to clarify the action mechanism of wilforine, the plasma membrane calcium transporting ATPase (PMCA) and inositol 1,4,5-trisphosphate receptor (IPR) from M. separata were studied.
View Article and Find Full Text PDFIntegrative colloidosomes with hierarchical structure and advanced function may serve as biomimetic microreactors to carry out catalytic reactions by compartmentalizing biological species within semipermeable membranes. Despite of recent progress in colloidosome design, integration of biological and inorganic components into tiered structures to tackle the remaining challenges of biocatalysis is highly demanded. Here, we report a rational design of three-tiered colloidosomes via the Pickering emulsion process.
View Article and Find Full Text PDFPurpose: To explore the feasibility of [Ga]Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) in patients with non-keratinizing nasopharyngeal carcinoma (NPC) and to evaluate whether [Ga]Ga-DOTATATE PET/CT could be used for non-invasive determination of somatostatin receptor 2 (SSTR2) expression in NPC.
Methods: This prospective study included patients with NPC who underwent [Ga]Ga-DOTATATE PET/CT between February and May 2021. The [Ga]Ga-DOTATATE and [F]FDG uptakes in primary and metastatic NPC lesions were calculated and compared, and the [Ga]Ga-DOTATATE uptake between SSTR2 score groups was analysed.
Purpose: This study aimed to investigate the diagnostic performance of [Ga]Ga-FAPI PET/CT for primary and metastatic pancreatic carcinoma lesions and compare the results with those of [F]-fluorodeoxyglucose ([F]FDG) PET/CT.
Methods: Patients with suspected or diagnosed pancreatic malignancy, who underwent contemporaneous [F]FDG and [Ga]Ga-FAPI PET/CT between June 2020 and January 2021, were retrospectively analyzed. Routine contrast-enhanced CT (CE-CT) is performed in all patients as standardized care.
Development of cortical tissue during infancy is critical for the emergence of typical brain functions in cortex. However, how cortical microstructure develops during infancy remains unknown. We measured the longitudinal development of cortex from birth to six months of age using multimodal quantitative imaging of cortical microstructure.
View Article and Find Full Text PDFHighly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) causes a serious disease to the swine industry worldwide. To understand the mechanisms of HP-PRRSV infection, RNA-seq-based transcriptome analyses were performed on porcine alveolar macrophages (PAMs) infected with a HP-PRRSV strain (TJ), a less virulent strain of a classical lineage (CH-1a), and a vaccine strain TJM-F92. Gene ontology, Kyoto Encyclopedia of Genes and Genomes analyses indicate that TJM-F92 led to significant up-regulation of gene expression for proteins associated with membrane-bound organelles.
View Article and Find Full Text PDFWater quality can have serious impacts on human health. One crucial issue of water pollution seriously affects our safety due to the continually emerging of discovered anthropogenic pollutants. The water treatment technologies are persistent improvement to adapt such new contaminants, which accelerates the evolution of materials science to explore solving the problems.
View Article and Find Full Text PDFPreeclampsia (PE) is a huge threat to pregnant women. Our previous study demonstrated that long non-coding RNA (lncRNA) NR_002794 was highly expressed in placentas of PE patients and could regulate the phenotypes of trophoblast cells. However, the downstream regulatory mechanisms of NR_002794 remain unknown.
View Article and Find Full Text PDFBackground: The increasing use of colistin causes a serious breach in our last line of defence against MDR Gram-negative pathogens. Our previous study showed that CpxR overexpression increases the susceptibility of acrB and cpxR double-deleted Salmonella enterica serovar Typhimurium to colistin.
Objectives: To identify the mechanism of CpxAR and efflux pumps that synergistically enhance the susceptibility of S.
The security issue of human health is faced with dispiriting threats from multidrug-resistant bacteria infections induced by the abuse and misuse of antibiotics. Over decades, the antimicrobial peptides (AMPs) hold great promise as a viable alternative to treatment with antibiotics due to their peculiar antimicrobial mechanisms of action, broad-spectrum antimicrobial activity, lower drug residue, and ease of synthesis and modification. However, they universally express a series of disadvantages that hinder their potential application in the biomedical field (e.
View Article and Find Full Text PDFSheng Wu Gong Cheng Xue Bao
August 2021
Online courses are an indispensable part of medical teaching in the new era. Online courses have good prospects, although also with certain problems in practice. As an important basic medical course, medical genetics has both basic theoretical knowledge and clinical cases, involving basic principles and the latest developments.
View Article and Find Full Text PDFTo use a quantitative approach to examine the effects of family interventions on physical activity (PA) and sedentary behavior (SB) in children aged 2. 5-12 years. PubMed, OVID, Web of Science, and others were searched from their inception to May 2020.
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