Drug-drug interaction of phenytoin sodium and methylprednisolone on voriconazole: a population pharmacokinetic model in children with thalassemia undergoing allogeneic hematopoietic stem cell transplantation.

Purpose: Voriconazole (VRC) is recommended for the prevention and treatment of invasive fungal infections in children undergoing hematopoietic stem cell transplantation (HSCT). It demonstrates nonlinear pharmacokinetics (PK) and exhibits substantial inter- and intraindividual variability. Phenytoin sodium (PHT) and methylprednisolone (MP) are commonly used in the early stages of HSCT to prevent epilepsy and graft-versus-host disease.

Evaluation of toxicity of polystyrene microplastics under realistic exposure levels in human vascular endothelial EA.hy926 cells.

Microplastics (MPs) have emerged as a global concern, with a recent study being the first to detect them in the bloodstream of healthy people. However, precise information regarding the toxic effects of MPs on the human vascular system is currently lacking. In this study, we used human vascular endothelial EA.

[Surveillance of populations in different periods in Suizhou City].

Objective: To evaluate the effect of malaria vector control measures so as to provide the evidence for consolidating the control effectiveness of malaria and carrying out the vector surveillance in Suizhou City.

Methods: The distributions of and were investigated by the combination of retrospective review and field survey. The changes of density and population of mosquito vectors were investigated and compared among various years.

[Survey of epidemic status of paragonimiasis in western mountainous areas in Hubei Province].

Objective: To understand the current status of paragonimiasis epidemic in western mountain areas in Hubei Province.

Methods: Four counties (cities) of Western Hubei Province (Xingshan, Enshi, Yunxi, Baokang) were selected as the investigation sites for active surveillance. Crabs were captured and the metacercariae of were detected.

[Application of ARIMA model on prediction of malaria incidence].

Objective: To predict the incidence of local malaria of Hubei Province applying the Autoregressive Integrated Moving Average model (ARIMA).

Methods: SPSS 13.0 software was applied to construct the ARIMA model based on the monthly local malaria incidence in Hubei Province from 2004 to 2009.