Publications by authors named "Wu De-Xi"
Article Synopsis
- Diabetic cardiomyopathy (DCM) leads to fatty acid accumulation in the heart, causing lipotoxicity that negatively affects heart function, while Adipsin may help mitigate these effects.
- A study was conducted on mice with a high-fat diet to explore how Adipsin influences DCM and identify its molecular interactions, using various advanced analytical methods.
- Results showed that Adipsin levels decreased in DCM, but increased Adipsin expression improved heart function and mitochondrial health by inhibiting the harmful interaction between Irak2 and key mitochondrial proteins.
Long-term treatment of spontaneously hypertensive rats with PD123319 and electrophysiological remodeling of left ventricular myocardium.
Naunyn Schmiedebergs Arch Pharmacol
December 2016
To investigate the effects of PD123319, an antagonist of angiotensin II subtype-2 receptor (AT2R), on the electrophysiological characteristics of the left ventricular hypertrophic myocardium in spontaneously hypertensive rats (SHR). A total of twenty-four 10-week-old male SHR were divided into two groups: PD123319 and non-PD123319 groups (n = 12 in each). Twelve 10-week-old Wistar-Kyoto rats served as the control group.
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