Moxibustion improves motor function by down-regulating SNX5 and inhibiting ferroptosis in neurons of corpus striatum in mice with Parkinson's disease.

Objectives: To explore the effect of moxibustion on the expression of sorting nexin 5 (SNX5), glutathione peroxidase (GPX4) and ferritin heavy chain (FTH1) in the corpus striatum in mice with Parkinson's disease (PD), so as to explore its mechanisms underlying improvement of PD by ameliorating ferroptosis in the substantia nigra striatum.

Methods: C57BL/6J mice were randomly divided into normal, sham operation, model, and moxibustion groups, with 10 mice in each group. The PD model was established by unilateral injection of 6-hydroxydopamine (3.

Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis.

Background: Gastric cancer (GC) is the fifth most common type of cancer and has the fourth highest death rate among all cancers. There is a lack of studies examining the impact of liver metastases on the effectiveness of immunotherapy in individuals diagnosed with GC.

Aim: To investigate the influence of liver metastases on the effectiveness and safety of immunotherapy in patients with advanced GC.

Prediction model of stress ulcer after laparoscopic surgery for colorectal cancer established by machine learning algorithm.

Background: Patients with colorectal cancer (CRC) are prone to stress ulcer after laparoscopic surgery. The analysis of risk factors for stress ulcer (SU) in patients with CRC is important to reduce mortality and improve patient prognosis.

Aim: To identify risk factors for SU after laparoscopic surgery for CRC, and develop a nomogram model to predict the risk of SU in these patients.

Adjuvant treatment for patients with incidentally resected limited disease small cell lung cancer-a retrospective study.

Background: With the exception of very early-stage small cell lung cancer (SCLC), surgery is not typically recommended for this disease; however, incidental resection still occurs. After incidental resection, adjuvant salvage therapy is widely offered, but the evidence supporting its use is limited. This study aimed to explore proper adjuvant therapy for these incidentally resected SCLC cases.

[Effects of Long-term Fertilization on Soil Nutrient Characteristics and Microbial Resource Restrictions in a Terrace on the Loess Plateau].

Long-term fertilization has an important effect on soil fertility and soil microbial activity. In order to explore the effects of long-term fertilization on soil extracellular enzyme activities and nutrient characteristics in a terrace on the Loess Plateau, we based our investigation on the long-term nutrient localization plot of Ansai Soil and Water Conservation Experimental Station, Chinese Academy of Sciences. We measured the soil physicochemical properties, microbial biomass, and extracellular enzyme activities of six fertilization treatments, which included no fertilization (CK); manure and nitrogen fertilization (MN); manure and phosphate fertilization (MP); manure, nitrogen, and phosphate fertilization (MNP); manure (M); and nitrogen and phosphate fertilization (NP).

A Recurrent Cryptic Rearrangement in an Adult Patient With Mixed-Phenotype Acute Leukemia, T/myeloid, NOS.

To define the fusion genes in T/myeloid mixed-phenotype acute leukemia (T/M MPAL), we performed transcriptome sequencing of diagnostic bone marrow samples from 20 adult patients. Our analysis identified a second instance of a recurrent chimeric gene resulting from the in-frame fusion of exon 23 of and exon 1 of , the first in an adult patient. The fusion gene was detected in both the diagnostic and relapsed blasts with reverse transcription-polymerase chain reaction and Sanger sequencing.

Collision-Energy Dependent Stereodynamics of Dissociative Charge Exchange Reaction between Ar and CO.

Long-distance charge-dipole attraction between atomic ion and randomly oriented polar molecule potentially makes the molecular orientation, which profoundly influences the products' kinetics of collisional reaction. Using the three-dimensional ion velocity map imaging technique, here we report a collision-energy dependent stereodynamics of dissociative charge exchange reaction Ar + CO → Ar + O + C in a range of 7.46-9.

Interleukin-5-induced eosinophil population improves cardiac function after myocardial infarction.

Aims: Interleukin (IL)-5 mediates the development of eosinophils (EOS) that are essential for tissue post-injury repair. It remains unknown whether IL-5 plays a role in heart repair after myocardial infarction (MI). This study aims to test whether IL-5-induced EOS population promotes the healing and repair process post-MI and to reveal the underlying mechanisms.

Superposition-state N produced in the intermolecular charge transfer from low-energy Ar to N.

Molecular electronic or vibrational states can be superimposed temporarily in an extremely short laser pulse, and the superposition-state transients formed therein receive much attention, owing to the extensive interest in molecular fundamentals and the potential applications in quantum information processing. Using the crossed-beam ion velocity map imaging technique, we disentangle two distinctly different pathways leading to the forward-scattered N yields in the large impact-parameter charge transfer from low-energy Ar to N. Besides the ground-state (XΣ ) N produced in the energy-resonant charge transfer, a few slower N ions are proposed to be in the superpositions of the XΣ -AΠ and AΠ-BΣ states on the basis of the accidental degeneracy or energetic closeness of the vibrational states around the XΣ -AΠ and AΠ-BΣ crossings in the non-Franck-Condon region.

Stereodynamics Observed in the Reactive Collisions of Low-Energy Ar with Randomly Oriented O.

Stereodynamics of the collisional reaction between mutually aligned or oriented reactants has been a striking topic of chemical dynamics for decades. However, the stereodynamic aspects are scarcely revealed for the low-energy collision with a randomly oriented target. Here in the dissociative charge-exchange reaction between randomly oriented O and low-energy Ar, we, using the three-dimensional ion velocity map imaging technique, clearly observe a linear alignment and a nearly isotropic distribution of the O yields along the collision axis.

Benign esophageal schwannoma: A case report and brief overview.

Rationale: Schwannoma is a tumor of the peripheral nervous system that originated in the Schwann cells of the neural sheath. Esophageal schwannomas are rare esophageal submucosal tumors, comprising approximately 2% of esophageal tumors. Since the symptoms, signs, and images of esophageal schwannoma are not specific, its preoperative diagnosis remains challenging.

Collision-Energy Dependence of the Ion-Molecule Charge-Exchange Reaction Ar + CO → Ar + CO.

Ion-molecule charge-exchange reactions Ar + CO → Ar + CO at the center-of-mass collision energies of 4.40, 6.40, and 8.

Ion momentum imaging study of the ion-molecule reaction Ar + O→ Ar + O.

Charge exchange reactions between Ar(P) and O (XΣ) are investigated in the collision energy range of 3.40-9.24 eV within the center-of-mass coordinate, by using the ion momentum imaging technique.

Ion Momentum Imaging Study of the Ion-Molecule Charge Exchange Reaction of Ar + CO.

Three-dimensional ion momentum imaging is developed in a combination of ion velocity map imaging technique and delay-line anode ion detection, and it is applied for the ion-molecule charge exchange reaction between Ar and CO. In a center-of-mass collision energy range of 7.23-15.

Salivary gland carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology.

Background: Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor salivary glands with oral cancer instead of with salivary gland carcinoma as a whole, because of the international disease coding.

Collision-Energy Dependence of the Ion-Molecule Charge Exchange Reaction Ar + NO.

High-lying quantum states of molecule are apt to be populated by translational-to-internal energy transfer in the collisions with atom, which usually becomes more significant with the increase of collision energy. However, in the charge exchange reaction Ar + NO → Ar + NO, the products NO prefer a dominant population at the lowest triplet state aΣ, in particular, in the higher energy collisions; the higher states bΠ and wΔ of NO are accessed only at the lower collision energies. Such a striking collision-energy dependence is attributed to two distinctly different processes: the former is controlled with an energetically resonant charge-transfer mechanism; while the latter experiences an intermediate complex (Ar-NO) which permits a more efficient translational-to-internal energy transfer.

Electroacupuncture exerts neuroprotective effects on ischemia/reperfusion injury in JNK knockout mice: the underlying mechanism.

Simple regulation of c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) pathways is not enough to trigger cell apoptosis. However, activation of the stress activated pathway (JNK/p38 MAPK) together with inhibition of the growth factor activated extracellular signal-regulated kinase (ERK) pathway can promote cell apoptosis. We hypothesized that inhibition of the JNK or p38 pro-apoptotic pathway and activating the ERK pathway could be the mechanism of anti-apoptosis following cerebral ischemia/reperfusion injury.

Note: A well-confined pulsed low-energy ion beam: Test experiments of Ar.

Here we report a pulsed low-energy ion beam source for ion-molecule reaction study, in which the ions produced by the pulsed electron impact are confined well in the spatial size of each bunch. In contrast to the ion focusing method to reduce the transverse section of the beam, the longitudinal section in the translational direction is compressed by introducing a second pulse in the ion time-of-flight system. The test experiments for the low-energy argon ions are performed.

Oral cancer incidence in Shanghai ---- a temporal trend analysis from 2003 to 2012.

Background: Oral cancer is a serious problem owing to its poor prognosis and destruction of patients' eating ability as well as facial appearance. Epidemiological studies can provide aetiological clues for prevention. The prevalence of oral cancer in densely populated cities in eastern China is unclear.

[Effect of Chinese medicine of nourishing kidney and clearing liver on intermittent hypoxia induced injury model of HUVECs through p38MAPK/NF-κB signaling pathway].

This study aims to explore the intervention effect of Chinese medicine of nourishing kidney and clearing liver on intermittent hypoxia(IH) induced injury model of HUVECs through p38MAPK/NF-κB signaling pathway in vitro. HUVECs injury model was induced by modified IH treatment. The effective components of Chinese medicine of nourishing kidney and clearing liver including isochteroside, aucubin and ligustrazine were used as intervention drugs.

Electroacupuncture reduces apoptotic index and inhibits p38 mitogen-activated protein kinase signaling pathway in the hippocampus of rats with cerebral ischemia/reperfusion injury.

Electroacupuncture attenuates cerebral hypoxia and neuronal apoptosis induced by cerebral ischemia/reperfusion injury. To further identify the involved mechanisms, we assumed that electroacupuncture used to treat cerebral ischemia/reperfusion injury was associated with the p38 mitogen-activated protein kinase (MAPK) signaling pathway. We established rat models of cerebral ischemia/reperfusion injury using the modified Zea-Longa's method.

Cancer incidence in urban Shanghai, 1973-2010: an updated trend and age-period-cohort effects.

Background: To provide a comprehensive overview of temporal trends in cancer incidence during 1973-2010 in urban Shanghai.

Methods: The estimated annual percent changes (EAPCs) for the whole period and for the time segments in age-standardized incidence rates (ASR) were evaluated with Joinpoint analysis. Age-period-cohort (APC) models were modeled to examine the effects of age, period and birth cohort on cancer incidence.

Brain activation and inhibition after acupuncture at Taichong and Taixi: resting-state functional magnetic resonance imaging.

Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture at Taichong (LR3) and Taixi (KI3) using resting-state functional magnetic resonance imaging.