Integrated Transcriptomic and Metabolomic Analysis of and Responses to Wilt Infection.

wilt (VW) caused by (Vd) is a devastating fungal cotton disease characterized by high pathogenicity, widespread distribution, and frequent variation. It leads to significant losses in both the yield and quality of cotton. Identifying key non-synonymous single nucleotide polymorphism (SNP) markers and crucial genes associated with VW resistance in and , and subsequently breeding new disease-resistant varieties, are essential for VW management.

Unequal Effects of the Lockdown on Mental Health in Shanghai: The Moderating and Mediating Role of Neighborhood Environment and Online Social Connections.

The COVID-19 pandemic profoundly impacted population mental health worldwide. Few studies examined how the neighborhood environment and online social connections might influence the social gradient in mental health during the pandemic lockdown. We aim to examine the moderating and mediating role of neighborhood environment and online social connections in the association between socioeconomic status (SES) and mental health outcomes.

Denture use and a slower rate of cognitive decline among older adults with partial tooth loss in China: A 10-year prospective cohort study.

Objective: Denture use has been shown to improve nutritional intake and diet quality in people with tooth loss. Despite evidence linking tooth loss and dementia, few studies have examined the association between denture use and cognitive decline. We investigated the relationship between denture use and cognitive decline among Chinese older adults with tooth loss.

METTL10 attenuates adriamycin-induced podocyte injury by targeting cell dedifferentiation.

Chronic kidney disease (CKD) is a worldwide public health problem. Podocyte damage is a hallmark of glomerular diseases including focal segmental glomerulosclerosis (FSGS) and one of the leading causes of CKD. Lysine methylation is a crucial post-translational modification.

High-Entropy Metal Interstitials Activate TiO for Robust Catalytic Oxidation.

Substitution metal doping strategies are crucial for developing catalysts capable of activating O, but the leaching of metal dopants has greatly hindered their potential for extensive oxidation reactions under mild conditions. Here, the study develops an entropy-increase strategy to synthesize high-entropy metal (Mg, Ca, Mn, Fe, and Co) interstitial functionalized anatase TiO (HE-TiO) nanosheets, demonstrating remarkable degradation efficiency across a wide pH range and exceptional stability in a flow-by electro-catalytic reactor. Relative to that of pristine TiO, the intense lattice distortion on the (001) plane, an average lattice expansion of 2% on the (100) plane, and decrease of second shell peak of X-ray absorption spectra serve as compelling evidence for the formation of metal interstitials in HE-TiO.

Caregiving in Asia: Priority areas for research, policy, and practice to support family caregivers.

Population aging presents a growing societal challenge and imposes a heavy burden on the healthcare system in many Asian countries. Given the limited availability of formal long-term care (LTC) facilities and personnel, family caregivers play a vital role in providing care for the increasing population of older adults. While awareness of the challenges faced by caregivers is rising, discussions often remain within academic circles, resulting in the lived experiences, well-being, and needs of family caregivers being frequently overlooked.

Racial and ethnic disparities in the burden of non-obese type 2 diabetes using different anthropometric measurements.

Aims: Compare racial/ethnic disparities in the prevalence of non-obese type 2 diabetes (T2D) and the proportion of non-obese individuals among T2D patients.

Methods: This cross-sectional study used ICD-9/10 codes to ascertain T2D. Participants were classified as non-obese by BMI (<25 kg/m for normal weight; <23 kg/m for Asian Americans), waist circumference (<102 cm for males, <88 cm for females), and waist-to-hip ratio (<0.

Influence of Inflammation on Red Blood Cell Lifespan in Peritoneal Dialysis Patients.

: Renal anemia is linked to a decreased lifespan of red blood cells. The factors influencing red blood cell lifespan (RBCLS) in peritoneal dialysis patients, particularly the connection between inflammation and RBCLS, are still not well understood. This cross-sectional study was conducted to investigate these relationships.

Multiple approaches to advance health equity in nursing science: Recruitment, data, and dissemination.

Ensuring equitable care and health outcomes for all populations is essential in nursing science. However, achieving health equity in nursing science necessitates a multifaceted approach to address the complex factors influencing health disparities. This paper presented the keynote address delivered at the Advanced Methods Conference hosted by the Council for Advancement of Nursing Science in 2023.

Epistasis between genetic variations on MdMYB109 and MdHXK1 exerts a large effect on sugar content in apple fruit.

Many quantitative traits are controlled by multiple genetic variations with minor effects, making it challenging to resolve the underlying genetic network and to apply functional markers in breeding. Affected by up to a hundred quantitative trait loci (QTLs), fruit-soluble sugar content is one of the most complex quantitative traits in apple (Malus sp.).

Transcriptome and metabolome analyses provide crucial insights into the adaptation of chieh-qua to infection.

Introduction: Chieh-qua ( Cogn. How) is a wax gourd variety that is generally susceptible to infection and damage by during its cultivation. Therefore, analyzing the adaption mechanism of chieh-qua to infection is of great significance for cultivating resistant varieties.

Measurement Practice of Slow Gait Speed for Motoric Cognitive Risk Syndrome: A Systematic Review.

Objectives: Individuals with motoric cognitive risk (MCR) syndrome have a high dementia risk. However, a knowledge gap exists in the measurement procedure for slow gait speed, which is a crucial component of MCR diagnosis. The study aimed to systematically review slow gait speed measurement practices in MCR diagnosis to identify critical constructs in gait speed measurement procedure.

Psychological distress in Asian American informal caregivers: an analysis by disaggregated ethnic groups.

Background: Despite Asians being the fastest-growing ethnic group in the US, most studies have focused on Asian Americans as an aggregate racial/ethnic group. The burden of mental health problems is increasing among caregivers due to population aging, yet little is known about the distress experienced by Asian caregivers when examined by disaggregated ethnic groups.

Methods: Using 2019-2020 California Health Interview Survey data, we examined disparities in psychological well-beings between non-Hispanic White and Asian American adult caregivers, with an emphasis on understudied Asian ethnic groups.

Non-invasive prenatal detection of dominant single-gene disorders in fetal structural abnormalities: a clinical feasibility study.

Objective: This study evaluated the accuracy of non-invasive prenatal testing (NIPT-SGDs) for dominant monogenic genetic diseases associated with fetal structural abnormalities and to assess the feasibility of clinical application.

Methods: Pregnant women requiring prenatal diagnosis due to fetal structural abnormalities were enrolled. Maternal peripheral blood was analyzed for cell-free DNA (cfDNA) using coordinative allele-aware target enrichment sequencing (COATE-seq).

Age at diagnosis of diabetes, obesity, and the risk of dementia among adult patients with type 2 diabetes.

Background: While Type 2 Diabetes Mellitus (T2DM) prevalence is increasing among younger individuals, few studies have examined how age at T2DM diagnosis relates to dementia risk in diabetic populations. We aimed to investigate the association between age at T2DM diagnosis and subsequent dementia risk, and to determine whether obesity moderates this relationship.

Methods: We conducted a prospective cohort study using data from the Health and Retirement Study (2002-2016) matched with its 2003 Diabetes Mail-Out Survey.

Oral health inequities over time among older adults of different racial/ethnic backgrounds: a comparative decomposition analysis across Australia and the United States.

Background: Although the prevalence of poor oral health among older populations in Australia and the United States is higher, the contribution of ethnicity status is unknown. We aimed to estimate the contribution of social inequalities in oral health among older populations in Australia and the United States.

Methods: Cross-sectional study design using data from Australia's National Survey of Adult Oral Health (NSAOH 2004-06 and 2017-18) and the United States' National Health and Nutrition Examination Survey (NHANES 2003-04 and 2011-16).

Relationship Between Primary Caregiving Type and a Peaceful End-Of-Life Experience Among Older Adults in China.

Few studies have compared pain management provided by informal and formal caregivers of older adults in China at the end of life. This study aims to address this gap by investigating the association between formal and informal care and painfulness at the end of life among older adults in China. Specifically, the study focuses on the influence of various types of informal care.

A longitudinal study of self-report tooth loss impacting functional status among Chinese older adults: moderated mediation of social relationships and psychological resilience.

Objectives: This study aimed to discern the longitudinal association between tooth loss and subsequent functional status, specifically investigating the moderated mediation effects of social relationships and psychological resilience.

Methods: Data from the 2011, 2014, and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were analyzed, we included 2,834 older adults aged 65 and over in the study. The longitudinal relationship between tooth loss and functional status was analyzed using the generalized estimating equation.

Immigrant Status, Social Support From Children, and Resilience for Older Parents' Perceived Oral Health Among Chinese Americans.

Improving the oral health of older immigrants is an important public health priority in the United States, but the role of children's support has received little attention. This study investigated the relationship between support from adult children and perceived oral health among foreign-born and U.S.

Home Health Care and Place of Death in Medicare Beneficiaries With and Without Dementia.

Background And Objectives: Home health care supports patient goals for aging in place. Our objective was to determine if home health care use in the last 3 years of life reduces the risk of inpatient death without hospice.

Research Design And Methods: We analyzed the characteristics of 2,065,300 Medicare beneficiaries who died in 2019 and conducted multinomial logistic regression analyses to evaluate the association between the use and timing of home health care, dementia diagnosis, and place of death.

Association Between Oral Hygiene Behaviours and Cognitive Decline in Adults: A Systematic Review and Meta-Analysis.

Aim: To evaluate the association between oral hygiene behaviour and cognitive decline in adults. The outcomes include changes in global cognitive function, visual attention, task switching and the risk of dementia.

Design: We conducted a systematic review following the preferred reporting items for systematic reviews and meta-analyses guidelines.