Publications by authors named "Wu Ai"

Macrophages - one of the crucial immune cells, are recruited to the cardiac tissue by chemokines, cytokines and upregulated endothelial adhesion molecules after myocardial infarction (MI). During the course of inflammation in the cardiac tissue, necrotic cells and matrix debris is phagocytosed by M1 macrophages. During the resolution phase of cardiac inflammation, M2 macrophages promote cardiac recovery.

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Alpinia zerumbet is a food flavor additive and a traditional medicine herb around the world. Several studies have reported that A. zerumbet has excellent effects on a variety of cardiovascular diseases, but its potential hypertensive applications, and pharmacokinetic features of main active substances have not been fully investigated.

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Heteroatom doping, involving the introduction of atoms with distinct electronegativity into carbon materials, has emerged as an effective approach to optimize their charge distribution. In this study, we designed a strategy to synthesize in-situ Mn, N co-doped carbon nanospheres (Mn-NC) through the polycondensation of 2,6-diaminopyridine and formaldehyde in synchronization with Mn chelation to form Mn-polytriazine precursor, followed by calcination to form carbonaceous solid. Then Mn-NC was fabricated into a capacitive deionization (CDI) electrode for the selective removal of uranium ions (U (VI)), which is commonly found in radioactive water.

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Ethnopharmacological Relevance: Alangium chinense has been used as traditional folk medicine for centuries to treat rheumatoid arthritis (RA) by Guizhou Miao nationality with remarkable clinical effect. But the mechanism of its anti-RA is not fully clarified.

Aim Of The Study: To explore the effect and underlying mechanism of A.

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This study outlines the synthesis of a novel, cost-effective composite material comprising calcium sulphate-modified biochar (Ca-BC) cross-linked with polyethyleneimine (PEI) and sodium alginate (SA), which was subsequently transformed into gel beads (Ca-BC@PEI-SA). These beads were engineered to enable effective cadmium ion (Cd(II)) adsorption from wastewater. Batch adsorption experiments were conducted to evaluate the effects of pH, contact time, temperature, and coexisting ions on adsorption performance.

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Non-invasive techniques for rapid blood testing are gaining traction in global healthcare as they optimize medical screening, diagnosis and clinical decisions. Fourier transform infrared (FT-IR) spectroscopy is one of the most common technologies that can be used for non-destructive aided medical detection. Typically, after acquiring the Fourier transform infrared spectrum, spectral data preprocessing and feature extraction and quantitative analysis of several indicators of blood samples can be accomplished, in combination with chemometric method studies.

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Unlabelled: Rosiglitazone (Avandia) and pioglitazone (Actos) belong to the class of thiazolidinediones (TZDs) drugs that act by increasing insulin sensitivity and are widely used for treating diabetic patients with insulin resistance. TZDs exhibit anti-inflammatory and antioxidant properties, then may play an active role in inhibiting plaque formation and coronary atherosclerosis. But the results of evidence-based medicine suggest that TZDs may increase the risk of cardiovascular adverse events.

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There is growing interest in deoxynivalenol (DON) exposure during puberty because experimental evidence shows that DON-exposed to adolescents are more sensitive to DON and have limited detoxification ability. Nevertheless, there have been few surveys of DON exposure for adolescents in China. Furthermore, little is known about the effects of collection times on risk exposure.

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Article Synopsis
  • Feature selection and sample partitioning are crucial for creating effective NIR spectroscopy models, with proposed improvements using a combination of simulated annealing (SA) and other algorithms.
  • A new method called SA-iPLS & SPXY-NSIA was developed, which optimizes both feature waveband selection and sample partitioning simultaneously through evolutionary processes.
  • Testing on soil sample datasets showed that this method outperformed traditional approaches, yielding better performance metrics and indicating its potential to enhance NIR analytical model predictions.
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Bacillus Thuringiensis (Bt) protein has a strong ability to complex with metal ions, which may increase the transport of metal ions in the soil multi-media system. In this study, the interactions between Cry1Ac protein and metal ions (Zn and Cd) were investigated through spectroscopies and molecular docking methods. The spectra results showed that both Zn and Cd quenched the fluorescence intensity of Cry1Ac protein through the static quenching.

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Article Synopsis
  • Water pollution poses a significant challenge for environmental development, and near-infrared (NIR) spectroscopy is a refined method for rapid detection of this issue.
  • Machine learning enhances NIR spectroscopy's ability to predict water pollution accurately, specifically using the least squares support vector machine (LSSVM) algorithm to build calibration models for determining chemical oxygen demand (a key water pollution indicator).
  • A novel kernel proposed in this study improves LSSVM's performance by integrating a logistic-based neural network, allowing for better parameter optimization and resistance to over-fitting, making it a promising tool for water resource management.
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Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of Severe fever with thrombocytopenia syndrome virus (SFTSV) infection, with a rapidly progressive central nervous system (CNS) disturbance, in Dongyang, Zhejiang Province, China, in 2017.

Case Presentation: A 64-year-old man was admitted to hospital after 4 days of fever.

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Background: Fowl adenovirus (FAdV) is an infectious agent that can cause jaundice, severe anaemia, dyspnoea and reproductive disorders in fowls. Since 2015, FAdV disease has been rapidly spreading among broiler chickens in China, where it has caused significant economic losses. In this study, a loop-mediated isothermal amplification (LAMP) real-time turbidity method with strong specificity to FAdV was established.

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Since mid-2015, numerous outbreaks of hydropericardium-hepatitis syndrome (HHS), which is caused by a novel fowl adenovirus serotype 4 (FAdV-4), have been reported in chickens in parts of China, thereby causing huge economic losses to the poultry industry. Thus, an effective vaccine to control the further spread of infections with this hyper-virulent FAdV-4 is imperative. In this study, we isolated a novel FAdV-4 strain SDJN0105 from a broiler farm with HHS disease in Shandong Province.

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Avian paramyxovirus type 4 (APMV-4) has been frequently reported from wildfowl and waterfowl in recent year. However, few studies have reported on the molecular characteristics and regional transmission of APMV-4, knowledge of which is important for understanding the genetic diversity and epidemiology of avian paramyxovirus. Herein, we report the isolation of one APMV-4 strain, designated as QY17, from the duck in eastern China.

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In 2017, a new type of goose-origin astrovirus (GoAstV) that is completely different from previously identified avian astroviruses (which have only 30.0% to 50.5% homology with GoAstV) has been isolated from diseased geese in China.

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Article Synopsis
  • A new type of goose-origin astrovirus (GoAstV) disease has emerged in China since 2017, causing severe health issues in geese, including joint swelling and high mortality rates exceeding 30%.
  • A strain named CXZ18 has been identified, causing fatal infections with notable visceral urate deposits, and it does not replicate in chicken or duck embryos, only in goose embryos.
  • Genetic analysis shows that CXZ18 is significantly different from other known avian astroviruses, indicating it belongs to a unique branch of these viruses.
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Coronary artery aneurysms are rare. We present an unusual case of an isolated coronary artery aneurysm in the obtuse marginal artery detected on a computed tomographic coronary angiogram, which is unlikely to be significant for the patient. A Medline literature search did not find a similar case.

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Photonic crystal (PC)-based devices have been widely used since 1990s, while PC has just stepped into the research area of nanofluidic. In this paper, photonic crystal had been used as a complementary metal oxide semiconductors (CMOS) compatible part to create a nanofluidic structure. A nanofluidic structure prototype had been fabricated with CMOS-compatible techniques.

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A nanofluidic biosensor based on nanoreplica molding photonic crystal (PC) was proposed. UV epoxy PC was fabricated by nanoreplica molding on a master PC wafer. The nanochannels were sealed between the gratings on the PC surface and a taped layer.

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The effects of crop rotation on sorghum [Sorghum biocolor (L) Moench] growth, rhizosphere microbial community and the activity of soil enzymes for successive crops of sorghum were evaluated. Five years of continuous monoculture sorghum as the control (CK) was compared to alfalfa and scallion planted in the fourth year. The results showed that incorporation of alfalfa and scallion into the rotation significantly improved sorghum shoot growth.

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We isolated a novel H5N2 avian influenza virus from swans in China. The virus was derived from a widespread H9N2 avian influenza virus but acquired the hemagglutinin gene from Eurasian H5 subtype with a naturally occurring in-frame deletion of four basic residues in the polybasic hemagglutinin cleavage site.

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A quantitative determination method for the diagnosis of hyperlipidemia was developed using Fourier transform infrared (FTIR) spectroscopy. Random forest (RF) was demonstrated as a potential multivariate algorithm for the FTIR analysis of low-density lipoprotein cholesterol (LDL-C) and tri-glycerides (TG) in human serum samples. The informative wavebands for LDL-C and TG were selected based on the Gini importance.

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Protein and total fat are two ingredients to measure the quality of corn. The aim of this study is to evaluate the quality of corn by the dual-component join determination through Fourier transform near infrared (FT-NIR) spectroscopic analysis. The calibration models were established by the systematic study performed respectively in the four regions of the whole range, the second overtone, the first overtone, and the combination.

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Synopsis of recent research by authors named "Wu Ai"

  • - Wu Ai's recent research focuses on the pharmacological applications of natural compounds, as evidenced by studies on Alpinia zerumbet for hypertension and Alangium chinense for rheumatoid arthritis, aiming to elucidate their therapeutic mechanisms and pharmacokinetic profiles.
  • - The author also explores innovative materials for environmental remediation, including the development of manganese and nitrogen co-doped carbon nanospheres for uranium capture, and calcium sulfate-modified biochar for cadmium removal from wastewater, showcasing a commitment to addressing pollution issues.
  • - Additionally, Wu Ai investigates advances in non-invasive medical diagnostics, particularly using Fourier transform infrared spectroscopy for blood testing, and employs machine learning techniques to enhance predictive modeling for water pollution assessment, indicating a multidisciplinary approach in his research.