Comparison of Double-Blind and Open Food Challenges for the Diagnosis of Food Allergy in Childhood: The ALDORADO Study.

Background: Double-blind placebo-controlled food challenge (DBPCFC) is widely regarded as the "gold standard" to diagnose food allergy. Maximum efforts are made to reduce bias, yet DBPCFCs are costly, time-, and resource-intensive. Less demanding open food challenges are increasingly used in clinical practice.

Eliciting and stop dose during oral food challenges for peanut and common tree nuts in different age groups.

Background: Oral food challenges (OFCs) are used to confirm or reject a diagnosis of food allergy. However, younger children may encounter difficulties in consuming all offered doses during an OFC in the absence of symptoms, resulting in inconclusive outcomes. Our aim is to assess the eliciting dose for objective symptoms among various age groups and determine the necessity of consuming the final dose step during an uneventful OFC to avoid false negative outcomes.

Evolution and morphology of a contourite depositional system based on new evidence from 3D-seismic data offshore Madagascar (Paleogene, Morondava Basin).

Numerous bottom current-controlled depositional and erosional features, which together form Contourite Depositional Systems (CDS), have been recognized in deep-water settings over the past decade. Most of these systems are described based on two-dimensional (2D) seismic data, whereas only a few CDS have been characterised from high-resolution 3D data. Here we document a newly identified CDS that formed during the Paleocene within the Morondava Basin, offshore west Madagascar, through analysis of a depth-migrated 3D seismic survey, enhanced by the implementation of seismic attributes.

Detection of Salivary Tryptase Levels in Children following Oral Food Challenges.

Background: Oral food challenge (OFC) is commonly used to diagnose food allergy. This test is time and resource intensive, and conclusions are not always unequivocal as this relies on the interpretation of symptoms. Therefore, an objective marker would improve the accuracy of the diagnostic workup of food allergy.

The dilemma of open or double-blind food challenges in diagnosing food allergy in children: Design of the ALDORADO trial.

Background: It is of major importance to diagnose food allergy accurately. Current guidelines support the use of oral food challenges to do so. The double-blind placebo-controlled food challenge (DBPCFC) has been regarded as the 'gold standard' for decades.

The Late Miocene Rifian corridor as a natural laboratory to explore a case of ichnofacies distribution in ancient gateways.

Oceanic gateways have modulated ocean circulation and have influenced climatic variations throughout the Earth´s history. During the late Miocene (7.8-7.

Determining Static Hyperinflation in Patients with Severe Emphysema: Relation Between Lung Function Parameters and Patient-Related Outcomes.

Background: Bronchoscopic lung volume reduction techniques are minor invasive treatment modalities for severely hyperinflated emphysema patients. The severity of static lung hyperinflation determines eligibility and success rate for these treatments. However, it is not exactly known what parameter should be used to optimally reflect hyperinflation.