Publications by authors named "Wouter Tjerk Rudolph Hooghiemstra"
Article Synopsis
- Monoclonal antibodies are crucial for treating inflammatory bowel disease (IBD), but many patients experience non-responsiveness, highlighting the need for better response prediction methods.
- Fluorescent imaging using labeled antibodies may help reveal drug distribution and engagement, but effective probes are necessary for accurate assessments.
- Out of 12 drug conjugates tested, 5 showed potential for development as clinical tracers, while others were deemed unfeasible due to issues like aggregation, reduced brightness, or poor binding.
Tumor-positive resection margins are present in up to 23% of head and neck cancer (HNC) surgeries, as intraoperative techniques for evaluation of the resection margins are lacking. In this study, we investigated the safety and potential clinical value of fluorescence-guided imaging (FGI) for resection margin evaluation in HNC patients. We determined the optimal cetuximab-800CW dose by quantification of intrinsic fluorescence values using multi-diameter single-fiber reflectance, single-fiber fluorescence (MDSFR/SFF) spectroscopy.
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