Rural Older Adults in Disasters: A Study of Recovery From Hurricane Michael.

Objective: This study aims for a greater understanding of how older adults (age 65 and older) in Jackson County, Florida, are prepared for and cope with the effects of a natural disaster.

Methods: A multidisciplinary, international research team developed a survey examining: (1) resources available to individuals aged 65+ in rural communities for preparing for a disaster; (2) challenges they face when experiencing a disaster; and (3) their physical, social, emotional, and financial needs when it strikes. The survey was administered with older adults (65+) in Jackson County, Florida, following Hurricane Michael in 2018.

The Localization of Phenolic Compounds in Liposomal Bilayers and Their Effects on Surface Characteristics and Colloidal Stability.

The interactions with and effects of five chemically distinct, bioactive phenolic compounds on the lipid bilayers of model dipalmitoylphosphatidylcholine (DPPC) liposomes were investigated. Complementary analytical techniques, including differential scanning calorimetry (DSC) and phosphorus and proton nuclear magnetic resonance spectroscopy (NMR), were employed in order to determine the location of the compounds within the bilayer and to correlate location with their effects on bilayer characteristics and liposomal stability. As compared to the phenolic compounds localized in the glycerol region of the DPPC head group within the bilayer, which enhanced the colloidal stability of the liposomes, compounds located closer to the center of the bilayer reduced vesicle stability as a function of time.

Heat content variability in the North Atlantic Ocean in ocean reanalyses.

Unlabelled: Warming of the North Atlantic Ocean from the 1950s to 2012 is analyzed on neutral density surfaces and vertical levels in the upper 2000 m. Three reanalyses and two observational data sets are compared. The net gain of 5 × 10 J in the upper 2000 m is roughly 30% of the global ocean warming over this period.

Radio Frequency-Activated Nanoliposomes for Controlled Combination Drug Delivery.

This work was conducted in order to design, characterize, and evaluate stable liposomes containing the hydrophobic drug raloxifene HCl (RAL) and hydrophilic doxycycline HCl (DOX), two potentially synergistic agents for treating osteoporosis and other bone lesions, in conjunction with a radio frequency-induced, hydrophobic magnetic nanoparticle-dependent triggering mechanism for drug release. Both drugs were successfully incorporated into liposomes by lipid film hydration, although combination drug loading compromised liposome stability. Liposome stability was improved by reducing the drug load and by including Pluronics® (PL) in the formulations.

Greenland ice sheet melt from MODIS and associated atmospheric variability.

Unlabelled: Daily June-July melt fraction variations over the Greenland ice sheet (GIS) derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) (2000-2013) are associated with atmospheric blocking forming an omega-shape ridge over the GIS at 500 hPa height. Blocking activity with a range of time scales, from synoptic waves breaking poleward (<5 days) to full-fledged blocks (≥5 days), brings warm subtropical air masses over the GIS controlling daily surface temperatures and melt. The temperature anomaly of these subtropical air mass intrusions is also important for melting.

Design, synthesis, antiviral activity, and pre-formulation development of poly-L-arginine-fatty acyl derivatives of nucleoside reverse transcriptase inhibitors.

The objective of this work was to design conjugates of anti-HIV nucleosides conjugated with fatty acids and cell-penetrating poly-L-arginine (polyArg) peptides. Three conjugates of polyArg cell-penetrating peptides with fatty acyl derivatives of alovudine (FLT), lamivudine (3TC), and emtricitabine (FTC) were synthesized. In general, the compounds exhibited anti-HIV activity against X4 and R5 cell-free virus with EC50 values of 1.

Hydroxypropyl cellulose stabilizes amorphous solid dispersions of the poorly water soluble drug felodipine.

Overcoming the low oral bioavailability of many drugs due to their poor aqueous solubility is one of the major challenges in the pharmaceutical industry. The production of amorphous solid dispersions (ASDs) of these drugs using hydrophilic polymers may significantly improve their solubility. However, their storage stability and the stability of their supersaturated solutions in the gastrointestinal tract upon administration are unsolved problems.

Good enough for America.

Adulterated and counterfeit drugs were pouring into the U.S. Providing poor medicines was a growing business, and the market was growing with the rapid expansion of the country itself.

Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs.

The influence of polymers on the dissolution, supersaturation, crystallization, and partitioning of poorly water soluble compounds in biphasic media was evaluated. Amorphous solid dispersions (ASDs) containing felodipine (FLD) and itraconazole (ITZ) were prepared by hot melt mixing (HMM) using various polymers. The ASDs were analyzed using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and HPLC.

Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo.

Cartilage destruction is a crucial process in arthritis and is characterized by the degradation of cartilage proteins, proteoglycans, and type II collagen (CII), which are embedded within the extracellular matrix. While proteoglycan loss can be reversed, the degradation of CII is irreversible and has been correlated with an over-expression and over-activation of matrix metalloproteinases (MMPs). Among the various MMPs, the collagenase MMP-13 possesses the greatest catalytic activity for CII degradation.

Low-viscosity hydroxypropylcellulose (HPC) grades SL and SSL: versatile pharmaceutical polymers for dissolution enhancement, controlled release, and pharmaceutical processing.

Hydroxypropylcellulose (HPC)-SL and -SSL, low-viscosity hydroxypropylcellulose polymers, are versatile pharmaceutical excipients. The utility of HPC polymers was assessed for both dissolution enhancement and sustained release of pharmaceutical drugs using various processing techniques. The BCS class II drugs carbamazepine (CBZ), hydrochlorthiazide, and phenytoin (PHT) were hot melt mixed (HMM) with various polymers.

Nonprescription drug abuse.

Nonprescription drug, also referred to as over-the-counter (OTC) abuse, is a serious and growing global health challenge. Drugs from many different therapeutic classes and numerous dosage forms and drug delivery systems are implicated in nonprescription drug abuse. Individuals who commonly abuse certain nonprescription medications are likewise diverse, varying in age, demographics, and overall health status.

Atmospheric blocking and Atlantic multidecadal ocean variability.

Atmospheric blocking over the northern North Atlantic, which involves isolation of large regions of air from the westerly circulation for 5 days or more, influences fundamentally the ocean circulation and upper ocean properties by affecting wind patterns. Winters with clusters of more frequent blocking between Greenland and western Europe correspond to a warmer, more saline subpolar ocean. The correspondence between blocked westerly winds and warm ocean holds in recent decadal episodes (especially 1996 to 2010).

Proceedings of the American Pharmaceutical Association: JAPhA centennial celebration.

From the beginning, APhA recognized and embraced the mission of keeping its members and all pharmacists informed and engaged in the progress of the profession. For the entire period encompassed by the Proceedings, print runs were for 1,000 copies or more, a far greater number than the membership list, which allowed for distribution to a broad audience both domestically and internationally. However, it was the meetings in 1856 and 1857 establishing the Report on the Progress of Pharmacy and the publication of NF in 1888 that truly moved the Association to the role of a major provider of information to the pharmacists of America.

In the hands of your enemy.

In the days of the post 9/11 attacks in the United States and the response against terrorism, one must question whether the source and supply of medicines in America is safe and adequate. This article reviews a common thread that runs through the periods of national emergency brought on by war, beginning with the Revolutionary War and repeated in the Civil War, World War 1, and World War 2: access to sufficient safe medicines. The shortage of medicines challenged the birth of the new nation in the Revolutionary War and helped thwart its destruction by the withdrawal of the southern states in the Civil War.