Genetic alteration in oral squamous cell carcinoma detected by arbitrarily primed polymerase chain reaction.

Oral cancer ranks as one of the top ten cancers in Thailand. Molecular carcinogenesis of this disease remains unknown. The purpose of this report was to identify the genetic alteration profile in Thai oral squamous cell carcinoma (OSCC) patients using arbitrarily primed PCR and to determine the association between genetic alterations and clinico-pathological characteristics.

Detection of human papillomavirus in oral squamous cell carcinoma, leukoplakia and lichen planus in Thai patients.

Although tobacco, alcohol abuse and betel nut chewing habit are well recognized risk factors for oral squamous cell carcinoma (OSCC), there is evidence to indicate that human papillomavirus (HPV) may also play some inducing role. The purpose of this study was to investigate the presence of HPV in Thai patients with oral squamous cell carcinoma, leukoplakia and lichen planus using the polymerase chain reaction (PCR). Biopsies of oral squamous cell carcinoma, leukoplakia and lichen planus were obtained from 65 patients, 15 males and 50 females, aged between 30- 88 years old.

Prostaglandin D2 pathway and peroxisome proliferator-activated receptor gamma-1 expression are induced by mechanical loading in an osteoblastic cell line.

Objective: The hypothesis underlying the current study was that the arachidonic acid cascade, specifically activation of the prostaglandin (PG) D(2) pathway in osteoblasts, is an anabolic signal induced by mechanical loading.

Background: Previous studies have shown that mechanical loading of osteoblasts triggers cyclooxygenase (COX)-2, PGE(2) and prostacyclin (PGI(2)) synthesis. Since modest mechanical loading of osteoblasts promotes bone formation, we sought to determine whether mechanical stress activates the osteoblastic PGD(2) pathway resulting in the synthesis of osteogenic cyclopentenones, including Delta(12)PGJ(2).

A retrospective study of 60 cases of salivary gland tumors in a Thai population.

Sixty cases of salivary gland tumors were diagnosed in the Oral Pathology Department, Faculty of Dentistry, Mahidol University, Bangkok, Thailand, from 1973 to 2002. Fifty-two cases (86.7%) involved the intraoral minor salivary glands, six cases (10%) were found in the major glands, and two cases (3.