Publications by authors named "Woosuk Kim"

(1) Background: This study evaluated the quality of medical imaging acquired using radiography, ultrasonography, and computed tomography (CT) in canine cadavers prepared with formalin solution, Thiel solution (TS), and saturated salt solution (SS). Additionally, the duration whereby image quality could be properly reproduced was investigated. (2) Methods: Nine dog cadavers, divided into three groups per embalming solution, were imaged pre- and post-embalming at 6 and 12 weeks using three different imaging modalities.

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  • The study investigates how different medications (heparin, aspirin, SNP) affect the risk of pulmonary thromboembolism (PTE) after injecting adipose tissue-derived mesenchymal stem cells (AdMSCs) in dogs.
  • This research involved administering fluorescently labeled AdMSCs to mice and comparing outcomes like survival rates and other health indicators across groups receiving the drugs and a control group.
  • Results showed that heparin significantly reduced PTE-related deaths compared to aspirin and SNP, suggesting its effectiveness in improving the safety of stem cell therapies in veterinary practice.
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Introduction: The external jugular vein (EJV) is a superficial vein of the neck in dogs; its significance is evident in veterinary clinical practice, encompassing surgeries and interventional procedures. However, there have been no reports on EJV variations in canines, despite extensive studies on variations in the jugular veins in humans. This study aimed to use CT imaging to evaluate the prevalence of anatomic vascular variations of the EJVs in Shih Tzu dogs and to describe the clinical and CT characteristics of these vascular variants.

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  • The study aimed to create a rat model of Chiari-like malformation, a condition seen in dogs and humans characterized by a small caudal cranial fossa that leads to cerebellar herniation.
  • The researchers analyzed MRI data from normal and affected dogs, measuring caudal cranial fossa volume and volume index, which revealed significant reductions in affected dogs.
  • The established rat model mirrored these findings, showing similar reductions and confirming cerebellar herniation, making it a useful tool for further research in understanding and treating Chiari-like malformation.
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  • This review explores Chiari-like malformation (CLM), a condition characterized by displacement of the hindbrain due to inadequate skull size, affecting both humans and animals.
  • CLM causes obstruction at the craniocervical junction, disrupting cerebrospinal fluid flow and potentially leading to syringomyelia, with symptoms like head tremors, ataxia, and pain.
  • While magnetic resonance imaging is essential for diagnosis, current treatments such as foramen magnum decompression provide only temporary relief, highlighting the need for further research on effective long-term treatment options.
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  • The study examined the impact of heat shock protein 10 (HSP10) on memory and neurogenesis in both adult and aged mice using a fusion protein called Tat-HSP10 for delivery.
  • Aged mice showed signs of cognitive decline and aging-related markers, but treatment with Tat-HSP10 improved their memory performance and increased the growth of new neurons in the hippocampus.
  • Tat-HSP10 also positively influenced key proteins and genes associated with hippocampal function, suggesting it may help alleviate aging effects on memory.
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  • The study aimed to examine the neuroprotective effects of Dendropanax morbifera extract (DME) against ischemic damage in gerbils by administering different doses (100 or 300 mg/kg) over three weeks before inducing ischemia.
  • Results showed that only the higher dose (300 mg/kg) significantly improved memory impairments related to ischemia and preserved a substantial percentage of neurons in the CA1 region of the hippocampus.
  • Additionally, the 300 mg/kg DME treatment reduced morphological changes in glial cells and decreased oxidative stress indicators, thereby supporting its potential neuroprotective properties.
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  • This study investigates how polycaprolactone (PCL), a flexible organic resin, affects the mechanical properties of cellulose nanocrystal (CNC) cement composites.
  • The researchers used various forms of PCL to determine the best adhesion with cement and found that dissolving PCL in a dichloromethane (DCM) solution improved this interaction, particularly with CNC modified using 3-aminopropyltriethoxysilane (APTES).
  • Results showed that while 1 vol.% PCL provided high dispersion stability and improved strength characteristics with PCL powder, the overall hydration and strength were lower compared to plain specimens, suggesting a complex relationship between PCL incorporation and performance.
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Purpose: Various operative treatment options for advanced thumb carpometacarpal (CMC) joint arthritis have been presented without a definite surgical guideline. Selective denervation is a less invasive method for thumb CMC arthritis. However, it is unclear whether the clinical outcome varies with the stage of thumb CMC arthritis.

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Background: Recent studies have demonstrated that the distal forearm dual-energy X-ray absorptiometry (DEXA) scan might be a better method for screening bone mineral density (BMD) and the risk of a distal forearm fracture, compared with a central DEXA scan. Therefore, the purpose of this study was to determine the effectiveness of a distal forearm DEXA scan for predicting the occurrence of a distal radius fracture (DRF) in elderly females who were not initially diagnosed with osteoporosis after a central DEXA scan.

Methods: Among the female patients who visited our institutes and who were over 50 years old and underwent DEXA scans at 3 sites (lumbar spine, proximal femur, and distal forearm), 228 patients with DRF (group 1) and 228 propensity score-matched patients without fractures (group 2) were included in this study.

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  • Somatostatin (SST) levels change during brain development, but its specific role, especially in the hippocampus, remains unclear.
  • This study examined SST expression in young mice and its effects on neurogenesis, finding that SST peaks at P14 and declines by P21 across various hippocampal regions.
  • The results suggest that SST is crucial for the temporary increase in neuroblast differentiation in the dentate gyrus during early postnatal development.
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  • Cuprizone causes damage to myelin and oligodendrocytes in mice, leading to reduced myelin basic protein (MBP) and activated microglia in brain regions like the hippocampus.
  • The study tested the neuroprotective effects of a fusion protein, PEP-1-SOD1, on cuprizone-induced damage and found that it partially mitigated microglial activation and MBP reduction.
  • However, PEP-1-SOD1 treatment did not significantly improve the overall demyelination or the proliferation of new neurons in the dentate gyrus, indicating limited effectiveness in protecting against cuprizone's harmful effects.
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  • This paper presents a new coding method for compressing phase-only hologram videos that can be displayed directly on commercial phase-only spatial light modulators.
  • The approach builds on existing video codecs as anchors, which allows for improved performance in coding methods for 3D data while enhancing compatibility and reducing development time.
  • Utilizing techniques like progressive scaling and deep neural networks, the proposed method achieves an average coding gain of 22% compared to the anchor, resulting in clearer images and reduced juddering in the final output.
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A sequence of 3D models generated using volumetric capture has the advantage of retaining the characteristics of dynamic objects and scenes. However, in volumetric data, since 3D mesh and texture are synthesized for every frame, the mesh of every frame has a different shape, and the brightness and color quality of the texture is various. This paper proposes an algorithm to consistently create a mesh of 4D volumetric data using dynamic reconstruction.

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Due to the amount of transmitted data and the security of personal or private information in wireless communication, there are cases where the information for a multimedia service should be directly transferred from the user's device to the cloud server without the captured original images. This paper proposes a new method to generate 3D (dimensional) keypoints based on a user's mobile device with a commercial RGB camera in a distributed computing environment such as a cloud server. The images are captured with a moving camera and 2D keypoints are extracted from them.

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  • Phosphoglycerate mutase 5 (PGAM5) is a glycolytic enzyme linked to cell death and mitochondrial regulation, with this study focusing on its impact on oxidative stress in HT22 cells and ischemic damage in gerbils.
  • Researchers used a PEP-1 expression vector to effectively deliver PGAM5 proteins into cells, observing increased cell protection against reactive oxygen species (ROS) and cell death, with sustained protein presence noted after 12 hours.
  • PEP-1-PGAM5 treatment also improved outcomes in gerbils post-ischemia, reducing hyperlocomotion and neuronal death, and mitigating oxidative stress indicators such as lipid peroxidation and glutathione levels.
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  • The study focuses on the vacuolar H-ATPase enzyme, particularly its subtype ATP6V1B2, and its expression changes in the hippocampus after transient forebrain ischemia in gerbils.
  • It investigates how the expression of ATP6V1B2 correlates with changes in pH and lactate levels to understand its role in neuronal health during ischemic conditions.
  • Findings indicate a transient increase in ATP6V1B2 expression in specific hippocampal regions post-ischemia, suggesting its potential compensatory role in responding to ischemic damage.
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This paper proposes a new technique for performing 3D static-point cloud registration after calibrating a multi-view RGB-D camera using a 3D (dimensional) joint set. Consistent feature points are required to calibrate a multi-view camera, and accurate feature points are necessary to obtain high-accuracy calibration results. In general, a special tool, such as a chessboard, is used to calibrate a multi-view camera.

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  • * In a study involving HT22 cells and gerbil models of ischemia, purpurin treatment reduced cell death and DNA fragmentation, while also lowering levels of pro-apoptotic proteins and inflammatory markers post-injury.
  • * Administration of purpurin after transient forebrain ischemia led to improved cell survival in the hippocampal CA1 region and decreased neuroinflammation, suggesting its role in protecting against brain damage caused by ischemia.
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  • Cuprizone induces demyelination in mice, particularly affecting the corpus callosum, and this study examines its impact on young adult (5-week-old) and aged (23-month-old) mice.
  • Young adult mice showed a significant reduction in myelin structures and an increase in proliferating cells and neuroblasts in response to cuprizone, while aged mice did not exhibit these changes due to lower basal levels of these cells.
  • Both age groups experienced increased demyelination and changes in neural progenitor cells, but the effects were more severe in young adult mice, linked to decreased levels of BDNF and pCREB in the dentate gyrus.
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We determine that type I interferon (IFN) response biomarkers are enriched in a subset of pancreatic ductal adenocarcinoma (PDAC) tumors; however, actionable vulnerabilities associated with IFN signaling have not been systematically defined. Integration of a phosphoproteomic analysis and a chemical genomics synergy screen reveals that IFN activates the replication stress response kinase ataxia telangiectasia and Rad3-related protein (ATR) in PDAC cells and sensitizes them to ATR inhibitors. IFN triggers cell-cycle arrest in S-phase, which is accompanied by nucleotide pool insufficiency and nucleoside efflux.

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: Hemostasis and local anesthetic injection are essential for minor hand surgeries under local anesthesia (LA). Wide awake local anesthesia no tourniquet (WALANT) became popular for achieving hemostasis without a tourniquet. However, a recent study reported that injection is more painful than tourniquet use in minor hand surgery.

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  • - The study investigates the role of the Prostaglandin E2 E-prostanoid 2 receptor (EP2) in inflammatory responses and its potential functions in the hippocampus, particularly focusing on its expression during different developmental stages in mice.
  • - Researchers used immunohistochemical staining and western blot techniques to measure EP2 levels in the brains of C57BL/6J mice at various postnatal days, revealing a decrease in EP2 immunoreactivity and protein levels with age.
  • - Findings indicate that EP2 is associated with neuroblasts in the dentate gyrus and suggests its importance in brain structure and adult neurogenesis, as evidenced by reduced levels in COX-2 knockout mice. *
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We investigated the effects of leaf extract (CVE) on a high-fat diet (HFD)-induced obesity and memory deficits. Male mice (5 weeks of age) were fed vehicle (distilled water), or 30, 100, or 300 mg/kg of CVE once a day for 8 weeks with an HFD. Treatment with CVE resulted in lower body weight and glucose levels in a concentration- and feeding time-dependent manner.

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