Publications by authors named "Woong Yoon"

Article Synopsis
  • - Patients with a history of gamma knife surgery for vestibular schwannoma can develop rare ruptured pseudoaneurysms in the distal anterior inferior cerebellar artery (AICA), and treatment usually involves either surgical trapping or endovascular occlusion.
  • - This study highlights the first use of endosaccular coil embolization to treat a ruptured pseudoaneurysm in AICA while preserving the artery, with the patient experiencing recanalization that required additional treatments over two years.
  • - The findings suggest that endosaccular coil embolization can be a safe approach for managing radiation-induced pseudoaneurysms, but ongoing monitoring and readiness for further interventions are essential due to the risk of regrowth. *
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  • Venous aneurysms associated with dural arteriovenous fistula (dAVF) typically arise from long-standing venous hypertension and present as an enlargement of the draining vein, but some saccular aneurysms can occur without clear evidence of hypertension, making them quite rare.
  • This report highlights two cases of ruptured saccular venous aneurysms linked to dAVF, both lacking signs of venous hypertension and exhibiting significant curvature or narrowing in the draining veins, which were successfully treated using transarterial embolization.
  • The findings suggest that while hemodynamic stress is important in the formation of venous aneurysms, prior venous hypertension is not essential for their development, emphasizing the
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Background: Endovascular therapy (EVT) is the treatment of choice for acute ischemic stroke (AIS) with large vessel occlusion. However, in many patients, successful EVT recanalization does not correspond to a clinical improvement, called futile recanalization (FR). We aimed to identify stroke risk factors and patient characteristics associated with FR in AIS with large core infarct (LCI).

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This study aimed to identify radiologic features that differentiate lymphoma from metastasis manifesting as a solid enhancing mass lacking necrosis in the cerebellum. Pathologically confirmed 24 primary central nervous system lymphoma (PCNSL) and 32 metastasis patients with solid enhancing cerebellar masses without necrotic or hemorrhagic components were retrospectively analyzed. We evaluated the imaging characteristics using contrast-enhanced magnetic resonance imaging (MRI).

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Our study retrospectively investigated differential patterns of the functional connectivity (FC) of core brain regions synchronous with morphometric changes associated with sexual dysfunction in menopausal women, and their correlations with sexual hormones. Twenty-three premenopausal women (mean age: 41.52 ± 7.

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Meningiomas are common primary brain tumors, and their accurate preoperative grading is crucial for treatment planning. This study aimed to evaluate the value of radiomics and clinical imaging features in predicting the histologic grade of meningiomas from preoperative MRI. We retrospectively reviewed patients with intracranial meningiomas from two hospitals.

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Article Synopsis
  • * Out of the patients, 8.6% had SCA occlusions, with 5 experiencing new infarctions in the SCA area; however, there were no major complications like cerebellar hemorrhage.
  • * The findings indicated that most SCA occlusions recanalized on their own, suggesting that additional treatment for these occlusions post-thrombectomy might not be necessary.
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Purpose: To investigate the utility of preoperative multiparametric magnetic resonance imaging (mpMRI)-based clinical-radiomic analysis combined with machine learning (ML) algorithms in predicting the expression of the Ki-67 proliferative index and p53 tumor suppressor protein in patients with meningioma.

Methods: This multicenter retrospective study included 483 and 93 patients from two centers. The Ki-67 index was classified into high (Ki-67≥5%) and low (Ki-67<5%)-expressed groups, and the p53 index was classified into positive (p53≥5%) and negative (p53<5%)-expressed groups.

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Article Synopsis
  • The study aimed to create and validate a deep learning tool, Neuro I, for automatic brain segmentation specifically for East Asians, and compared its performance to Freesurfer, a commonly used software in this area.
  • Using MRI scans from 30 healthy participants and training the algorithm on data from 776 healthy Koreans, the researchers assessed the accuracy of both methods through metrics like the Dice coefficient and correlation analyses.
  • Results showed that Neuro I outperformed Freesurfer, as indicated by significantly higher Dice values and better consistency across different ages, suggesting that Neuro I could serve as a more accurate alternative for measuring brain volume.
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Over the last 10 years, there has been a rise in neurointerventional case complexity, device variety and physician distractions. Even among experienced physicians, this trend challenges our memory and concentration, making it more difficult to remember safety principles and their implications. Checklists are regarded by some as a redundant exercise that wastes time, or as an attack on physician autonomy.

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Background: Mechanical thrombectomy (MT) is a primary endovascular modality for acute intracranial large vessel occlusion. However, further treatment, such as rescue stenting, is occasionally necessary for refractory cases. We aimed to investigate the efficacy and safety of rescue stenting in first-line MT failure and to identify the clinical factors affecting its clinical outcome.

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Purpose: To assess patient radiation doses during diagnostic and therapeutic neurointerventional procedures from multiple centers and propose dose reference level (RL).

Materials And Methods: Consecutive neurointerventional procedures, performed in 22 hospitals from December 2020 to June 2021, were retrospectively studied. We collected data from a sample of 429 diagnostic and 731 therapeutic procedures.

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Background And Purpose: This study aimed to investigate the effectiveness and safety of intravenous infusion of tirofiban after emergent angioplasty with or without stenting in patients with intracranial atherosclerotic stenosis-related large-vessel occlusion stroke.

Methods: We performed a retrospective case series study of 98 patients who underwent thrombectomy followed by angioplasty with or without stenting to treat intracranial atherosclerotic stenosis-related large-vessel occlusion. Patients were divided into 2 groups: those who received continuous intravenous infusion of tirofiban for 12 hours after procedure (intravenous tirofiban group, n=30) and those who did not receive postprocedural intravenous tirofiban (control group, n=68).

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Article Synopsis
  • - The study investigates the ability of hyperpolarized C MRI to differentiate between radiation-induced necrosis and tumor recurrence in the brain, which is significant for effective management in neuro-oncology.
  • - Using mouse models, researchers compared metabolic information (specifically lactate and pyruvate levels) in irradiated brain tissue versus brain tumors, finding significant metabolic differences that could aid in differentiation.
  • - Results showed that normalized lactate and the lactate-to-pyruvate ratio were notably lower in radiation necrosis compared to glioma and lung carcinoma metastasis, correlating with histological findings that indicated differences in cellularity between the two conditions.
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Current organoid models are limited by their inability to mimic mature organ architecture and associated tissue microenvironments. Here we create multilayer bladder 'assembloids' by reconstituting tissue stem cells with stromal components to represent an organized architecture with an epithelium surrounding stroma and an outer muscle layer. These assembloids exhibit characteristics of mature adult bladders in cell composition and gene expression at the single-cell transcriptome level, and recapitulate in vivo tissue dynamics of regenerative responses to injury.

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The early detection and rapid quantification of acute ischemic lesions play pivotal roles in stroke management. We developed a deep learning algorithm for the automatic binary classification of the Alberta Stroke Program Early Computed Tomographic Score (ASPECTS) using diffusion-weighted imaging (DWI) in acute stroke patients. Three hundred and ninety DWI datasets with acute anterior circulation stroke were included.

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Article Synopsis
  • - MRI is essential for assessing mediastinal masses since it can differentiate lesions that look unclear on CT and X-rays.
  • - A three-compartment model helps radiologists accurately locate and diagnose various types of mediastinal masses using their understanding of MRI techniques.
  • - The review includes images of different mediastinal masses, such as thymic hyperplasia, lymphoma, and neurogenic tumors, classified according to the International Thymic Malignancy Interest Group's system.
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  • Sellar spine is a rare bony spur from the dorsum sellae with possible origins linked to a cephalic ossified notochordal remnant.
  • It is often found incidentally and may be associated with conditions like precocious puberty or hypopituitarism, but not previously reported in Cushing's syndrome cases.
  • A case of a 29-year-old woman with Cushing's disease revealed a sellar spine during various diagnostic procedures, suggesting a potential link between the spine and her condition, though the exact cause remains unclear.
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Background: The association between pretreatment brain stem infarction and thrombectomy outcomes remains to be elucidated in patients with acute basilar artery occlusion (BAO). We aimed to assess the association between pretreatment pontine infarction and extremely poor outcome in patients who underwent endovascular thrombectomy due to acute BAO.

Methods: We retrospectively reviewed data from a stroke database to identify patients with acute BAO who underwent thrombectomy between January 2011 and August 2019.

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Quantification of intratumoral heterogeneity is essential for designing effective therapeutic strategies in the age of personalized medicine. In this study, we used a piezoelectric inkjet printer to enable analysis of intratumoral heterogeneity in a bladder cancer for the first time. Patient-derived tumor organoids were dissociated into single cell suspension and used as a bioink.

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Purpose: This study aimed to identify independent predictors of favorable outcomes associated with emergent carotid artery stenting (CAS) in patients with acute anterior circulation stroke.

Materials And Methods: This study included 93 patients with acute stroke who underwent emergent CAS to treat stenoocclusive lesions in the cervical internal carotid artery (ICA) within 6 hours of the onset of the associated symptoms. Data were compared between patients with and without favorable outcomes.

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Objective: Avoiding a catastrophic outcome may be a more realistic goal than achieving functional independence in the treatment of acute stroke in octogenarians. This study aimed to investigate predictors of catastrophic outcome in elderly patients after an endovascular thrombectomy with an acute anterior circulation large vessel occlusion (LVO).

Materials And Methods: Data from 82 patients aged ≥ 80 years, who were treated with thrombectomy for acute anterior circulation LVO, were analyzed.

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Background And Purposes: The role of endovascular recanalization in the treatment of cancer patients with acute stroke remains elusive. Our study aimed to investigate the clinical and imaging outcomes of endovascular recanalization treatment in patients with acute large vessel occlusion stroke who had active cancer.

Methods: We retrospectively reviewed the data from our stroke registry from January 2011 to September 2016 which was collected prospectively.

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The algal cell immobilization is a commonly used technique for treatment of waste water, production of useful metabolites and management of stock culture. However, control over the size of immobilized droplets, the population of microbes, and production rate in current techniques need to be improved. Here, we use drop-on-demand inkjet printing to immobilize spores of the alga Ecklonia cava within alginate microparticles for the first time.

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