Calcium Electroporation for Keloids: A First-in-Man Phase I Study.

Background: Keloid scarring is a pathologic proliferation of scar tissue that often causes pruritus, pain, and disfigurement. Keloids can be difficult to treat and have a high risk of recurrence. Recent studies have shown promising results in the treatment of cutaneous metastases with intralesional calcium combined with electroporation (calcium electroporation).

Calcium electroporation for treatment of cutaneous metastases; a randomized double-blinded phase II study, comparing the effect of calcium electroporation with electrochemotherapy.

Background: Calcium electroporation is a novel anticancer treatment, which utilizes high voltage pulses to permeabilize cell membranes and expose the cell to supraphysiological doses of calcium. Preclinical studies on calcium electroporation have shown strikingly high tumor response with cell necrosis. Calcium electroporation builds on the treatment electrochemotherapy, where chemotherapeutic drugs, mostly bleomycin, are internalized by electroporation.

Gene Status Affects Survival in Advanced Mycosis Fungoides.

is frequently mutated in different types of neoplasms including leukemia and lymphomas. Mutations of have also been reported in mycosis fungoides (MF), the most common type of cutaneous lymphoma. However, little is known about the frequency, spectrum of mutations, and their prognostic significance in MF.

Dermatofibrosarcoma protuberans: clinical series, national Danish incidence data and suggested guidelines.

Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma that frequently recurs locally, but rarely metastasizes. The purpose of this work is to present a clinical series of DFSP patients and national Danish incidence data in the period 2000-2012. Furthermore, the aim is to present guidelines on the management based on a review of the literature.

[A primary adenomucinous carcinoma on the upper eyelid].

In this case we present a 70-year-old male with a primary adenomucinous carcinoma (PKMK) on the upper eyelid. Radical surgery or radiotherapy could not be implemented, due to aggressive behaviour caused by dementia. PKMK is a rare tumour with 228 described cases.

Comparison of pressurized solvent and reflux extraction methods for the determination of perfluorooctanoic acid in polytetrafluoroethylene polymers using LC-MS-MS.

Both pressurized solvent extraction (PSE) and reflux extraction in various solvents were used to select the most efficient system for the determination of the quantity of perfluorooctanoic acid (PFOA) present in polytetrafluoroethylene polymers. After evaporating the solvent, PFOA was determined using liquid chromatography tandem mass spectrometry. Ethanol, water and methanol gave comparable results and were shown to be good solvents for this extraction.

Herniation of the heart after intrapericardial pneumonectomy.

Acute cardiac herniation after a radical rightsided pneumonectomy occurred in a 69-year-old man. Approximately 40 cases from the literature are discussed. Early recognition and emergency treatment are essential for patient survival of what showed to be a preventable complication of lung resection.

Experience with tissue heart valves.

Experience with tissue valves for heart valve replacement over the past seven years is presented and analyzed. Between February 1967 and March 1969, 87 patients had heart valves replaced with preserved heterologous aortic valves. Valve failure occurred in 19 of the 70 operative survivors.

Replacement of heart valves with frame-mounted tissue grafts.

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