Preliminary Study of Wound Oxygenation Comparing Skin Substitutes and Dressings.

Background: Improving oxygen delivery to challenging wound types has been shown to optimize and accelerate several key contributors to healing. This study aims to compare selective skin substitutes and primary dressings and evaluate their ability to transfer oxygen to the wound.

Methods: Visual and quantitative methods were employed to measure gas and fluid movement across several skin substitutes, including a bilayer nylon and silicone dressing coated with porcine gelatin and aloe vera (CNS), a porous bovine collagen-glycosaminoglycan (GAG) matrix dressing coated with silicone (UBC), and a urethane biodegradable temporizing matrix (PFD).

Creating safe and healing environments: Innovative curriculum to support team members during patient and family escalations in a quaternary care pediatric hospital.

Workplace violence in healthcare settings is at a crisis point. Healthcare organization have almost as many serious injuries from violence then all other industries combined (OSHA, 2013; Phillips, 2016). The costs of workplace violence have reached a crescendo provoking a response from several leading healthcare organizations including the Center for Disease Control, Occupational Safety and Health Administration, American Organization of Nurse Executives, American Nurse Association, and the Joint Commission who have all prioritized workplace violence initiatives.

In Vitro Characterization of Variable Porosity Wound Dressing With Anti-Scar Properties.

New options are needed to improve wound healing while preventing excessive scar formation. Temporary primary dressings are important options in topical wound management that allow the natural healing process. We evaluated a novel primary dressing consisting of a biosynthetic, variable porosity, matrix-containing gelatin and Aloe Vera extract and a derivative dressing coated with the anti-scarring agent salinomycin for their ability to promote cell growth, reduce myofibroblast formation, and regulate cytokine production.

Evaluating a Variable Porosity Wound Dressing With Anti-Scar Properties in a Porcine Model of Wound Healing.

New treatments that promote wound healing while preventing scar formation are needed. One option in topical wound healing is the use of temporary dressings that allow the natural healing process with minimal scar formation. We evaluated the temporary wound dressings PermeaDerm C, and a PermeaDerm C derivative coated with the anti-scarring agent, salinomycin (PermeaDerm D) in a pig model of wound healing to show the efficacy of these wound dressings in vivo.

Evolution of a Biosynthetic Temporary Skin Substitute: A Preliminary Study.

Objective: To compare PermeaDerm to first temporary biosynthetic skin substitute (Biobrane, cleared by the Food and Drug Administration in 1979).

Methods: Different temporary skin substitutes (Biobrane, PermeaDerm, and PermeaDerm derivatives) were tested for physical differences, impact on healing wounds, inflammatory response, and ability to allow adequate growth of dermal fibroblasts and mesenchymal stem cells without accumulation of excessive scar-forming myofibroblasts. Proliferation of fibroblasts and stem cells on various skin substitutes was measured, and myofibroblast marker accumulation was evaluated by the expression of α-smooth muscle actin and fibronectin.