Publications by authors named "WooHyun Kim"
Article Synopsis
- - The study focuses on creating Sn-doped GeSe (SnGS2) films via atomic layer deposition (ALD) for arsenic-free Ovonic threshold switch (OTS) devices that have low off-current and a desirable threshold voltage.
- - Undoped GeSe films display high performance and endurance but suffer from a large mobility gap; doping with Sn improves these properties by transforming pre-deposited SnN into SnSe through a special process involving NH and Se precursors.
- - The resulting SnGS2 films, with about 9.6% Sn concentration, allow for the fabrication of both planar and vertical OTS devices, showing impressive switching performance with a low threshold voltage of around 3.5 V and enduring
Acidisoma cladoniae sp. nov., an acidotolerant bacterium isolated from an Antarctic lichen.
Antonie Van Leeuwenhoek
September 2024
Article Synopsis
- A new bacterial strain, PAMC 29798, was discovered in an Antarctic lichen, characterized as a Gram-staining-negative, aerobic, non-motile coccobacilli with specific growth conditions.
- It demonstrates acidotolerance and psychrotolerance, thriving at low pH (optimally pH 4.0-6.5) and temperatures (optimally 10-20 °C).
- Phylogenetic analysis places it in the genus Acidisoma and proposes it as a new species named Acidisoma cladoniae, distinguishing it genomically from its close relatives.
On-farm dairy processing plants, which are situated close to farms and larger dairy processing facilities, face unique challenges in maintaining environmental hygiene. This can impact various stages of dairy processing. These plants operate on smaller scales and use Low-Temperature-Long-Time (LTLT) pasteurization, making them more susceptible to microbial contamination through direct and indirect contact.
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- - The study investigated how polystyrene microplastics (MPs) of different charges and sizes are absorbed by intestinal cells and examined the protective effects of green tea extracts (GTEs) against this absorption in Caco-2 cells.
- - Smaller, amine-modified MPs (0.2 μm) were found to significantly reduce cell viability compared to larger MPs and carboxylate-modified variants, suggesting size and charge influence toxicity.
- - Co-treatment with GTEs not only reduced the cytotoxic effects of amine-modified MPs but also improved the intestinal barrier function by limiting MP absorption and enhancing cell integrity.
Article Synopsis
- - Listeria monocytogenes is a harmful bacteria causing listeriosis, particularly found on chicken meat, which can easily become contaminated during butchery.
- - This study investigated contamination sources and routes at an abattoir that tested positive for Listeria over three years (2019-2021), using both culture-dependent and culture-independent methods for thorough analysis.
- - Findings showed that contamination predominantly occurred in the clean zone of the slaughterhouse, with significant links to chilling water and shackles, and culture-independent methods like qPCR provided better insight into contamination points than traditional methods.
Article Synopsis
- - Memristor-based physical reservoir computing (RC) struggles to effectively process complex data because traditional methods assign only one input to each memristor, which limits capturing spatial relationships.
- - A new "graph reservoir" system is introduced, utilizing a metal cell in a diagonal-crossbar array (mCBA) with dynamic memristors to better store and represent correlations between input signals.
- - This innovative approach yields impressive results, achieving a 0.09 error rate in time series prediction, 97.21% accuracy in recognizing handwritten digits (MNIST), and 80.0% accuracy in diagnosing human brain connectivity.
Kinetic conversion of BIOGF1K enriched in compound K from 3-D human tissue model.
Curr Res Pharmacol Drug Discov
October 2023
Article Synopsis
- The study aimed to assess the impact of ginsenosides from BIOGF1K, particularly compound K (CK) and compound Y (CY), on skin barrier function and their absorption into a 3-D human tissue model.
- Results showed that BIOGF1K treatment significantly improved skin barrier integrity compared to individual treatments of CY or CK.
- Additionally, the amount of CK absorbed into the skin was much higher when treated with BIOGF1K, indicating its potential effectiveness as a cosmetic product for improving skin health.
Article Synopsis
- Melanocortins are important for managing stress, inflammation, and skin color, with a focus on the MC1R (melanocortin 1 receptor) known for its role in pigmentation and anti-inflammatory responses.
- The review covers the structure and signaling pathways of MC1R and explores related diseases, emphasizing therapeutic options like synthetic peptides and small molecules that enhance drug stability and effectiveness.
- It highlights the broader potential of MC1R-targeted therapies beyond pigmentation issues, indicating their usefulness in treating various inflammatory diseases and calling for more research in this field.
Red ginseng, widely used in traditional medicine for various conditions, imparts health benefits mainly by modulating the gut microbiota in humans. Given the similarities in gut microbiota between humans and dogs, red ginseng-derived dietary fiber may have prebiotic potential in dogs; however, its effects on the gut microbiota in dogs remain elusive. This double-blinded, longitudinal study investigated the impact of red ginseng dietary fiber on the gut microbiota and host response in dogs.
View Article and Find Full Text PDFsp. nov., isolated from freshwater of the pond in Cambridge Bay, Canada.
Int J Syst Evol Microbiol
June 2023
A Gram-stain-negative, aerobic, reddish-coloured, rod-shaped and non-motile strain PAMC 29467, was isolated from freshwater of the pond in Cambridge Bay, Canada. Strain PAMC 29467 was closely related to (98.1 % 16S rRNA gene similarity).
View Article and Find Full Text PDFBackground: During the coronavirus disease 2019 (COVID-19) pandemic, there was a shortage of medical resources and the need for proper treatment guidelines for brain tumor patients became more pressing. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, has undertaken efforts to develop a guideline that is tailored to the domestic situation and that can be used in similar crisis situations in the future. As part II of the guideline, this consensus survey is to suggest management options in specific clinical scenarios during the crisis period.
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- The Korean Society for Neuro-Oncology (KSNO) developed treatment guidelines for brain tumor patients during the COVID-19 pandemic to address medical resource limitations and ensure proper care during crises.* -
- A group of 22 neuro-oncology experts used the Delphi method to reach a consensus on recommendations, prioritizing surgeries and therapies based on the urgency of patient needs during a crisis.* -
- The guidelines emphasize maintaining adequate care for brain tumor patients and suggest utilizing telemedicine as a vital management tool in future health crises.*
Article Synopsis
- The study investigates the effects of BIOGF1K, a ginseng root extract high in ginsenosides, on skin barrier function and how these compounds are absorbed in the skin.
- Upon treatment with BIOGF1K, human keratinocytes showed improved electrical resistance, indicating enhanced epidermal barrier function, particularly with ginsenosides CK and CY being the most abundant.
- The research found that CY is converted to CK as it penetrates the skin, suggesting that BIOGF1K could be an effective cosmeceutical for skin health.
Article Synopsis
- - The study investigates how retinol is absorbed and converted in human skin cells (HaCaT) and artificial skin, focusing on skin barrier integrity and transport over time.
- - Key findings show that while retinol maintains the strength of the skin barrier in HaCaT cells, its uptake decreases over time; retinoic acid, a metabolite of retinol, is identified as being transported through the skin layers.
- - The results suggest that the effectiveness of topical retinol for promoting skin health is dependent on its concentration and exposure duration, emphasizing its potential to enhance both barrier function and overall skin condition.
Article Synopsis
- The study investigates the public health risks associated with two variants of the mobilized colistin resistance gene, mcr-1.1 and mcr-3.1, found in E. coli from swine farms.
- Findings show that mcr-1.1 has a high ability to transfer between bacteria, while mcr-3.1 transfers less frequently but can also integrate into bacterial chromosomes.
- The results suggest that mcr-1.1 may lead to rapid spread of colistin resistance, whereas mcr-3.1 has a complex transmission strategy involving both horizontal and vertical mechanisms, which helps it persist despite lower transfer rates.
Article Synopsis
- - The study addresses the challenge of analyzing dynamic, interconnected big data represented as non-Euclidean graphs, where conventional methods struggle to find effective similarities between nodes.
- - Researchers propose mapping these non-Euclidean graphs to a crossbar array (CBA) of memristors, utilizing sneak current to identify node similarities and predicting future connections, community connectivity, and brain neural connections.
- - By connecting the CBA's bit lines to ground, the sneak current can be suppressed for adjacent node searches, demonstrating a physical computation method that mitigates typical issues faced with memristors.
Article Synopsis
- - Three key factors (body weight gain, intestinal lesion score, and fecal oocyst shedding) were analyzed in broilers infected with major parasites, revealing differences in their impact based on age and gender of the birds.
- - Two-week-old chickens exhibited a stronger correlation between intestinal lesion score and body weight gain when infected with Eimeria, as opposed to older chickens.
- - Broilers infected with a specific parasite showed a more significant connection between body weight gain and intestinal lesion score, highlighting the importance of considering gender, age, and species in related experiments.
Antimicrobial-resistant gram-negative bacteria in dairy products can transfer antimicrobial resistance to gut microbiota in humans and can adversely impact the product quality. In this study, we aimed to investigate their distribution in dairy processing lines and evaluate biofilm formation and heat tolerance under dairy processing line-like conditions. Additionally, we compared the relative expression of general and heat stress-related genes as well as spoilage-related gene between biofilm and planktonic cells under consecutive stresses, similar to those in dairy processing lines.
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- Social deficits are important characteristics of neuropsychiatric disorders like autism and ADHD, but their neural mechanisms are still not fully understood.
- Research on IRSp53/Baiap2-mutant mice, which exhibit social deficits, reveals that their medial prefrontal cortex (mPFC) neurons have reduced ability to encode social information compared to wild-type mice.
- Treatment with memantine can improve social deficits in these mutant mice by enhancing the activity of their mPFC neurons, indicating that changes in neuronal firing dynamics contribute to social behavior impairments.
Article Synopsis
- Atomic Layer Deposition (ALD) successfully creates Sb Te /GeTe superlattice films on both planar and vertical surfaces with a specific orientation due to the unique chemical interaction between the ALD precursor and the substrate.
- The superlattice film demonstrates a significantly lower reset current, about 1/7 of that of randomly oriented Ge Sb Te alloys, indicating improved performance.
- The switching process transforms the superlattice into a (111)-oriented face-centered-cubic structure, with induced compressive stress that aids in the movement of Ge atoms, leading to enhanced functionality in reset operations.
Article Synopsis
- A new computing scheme is needed to tackle complex tasks in the growing field of big data, and probabilistic computing (p-computing) offers a solution using probabilistic bits (p-bits).
- This study introduces p-computing through the behavior of a specific type of memristor known as CuTe/HfO/Pt (CTHP), which utilizes threshold switching for its operations.
- The p-bits created from these memristors can represent '0' or '1' with a probability influenced by input voltage, allowing for the execution of all 16 Boolean logic operations, as well as more complex tasks like full addition and factorization.
CD127, also named interleukin-7 receptor (IL-7R), is expressed on various cell types including naive and memory T cells, and plays a critical role in the differentiation and activation of T lymphocytes. The availability of poultry-specific immune reagents to identify and measure chicken CD127 response will enhance fundamental and applied research in poultry immunology. Mouse monoclonal antibodies (MAbs) against chicken CD127 (chCD127) were developed and characterized.
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- Wild migratory birds play a crucial role in maintaining healthy ecosystems, yet the impact of rehabilitation on their gut microbiomes is not well-understood.
- In a study involving six species of wild migratory birds in South Korea, researchers found that gut microbiome diversity decreased during rehabilitation and did not return to normal levels, leading to an increase in harmful pathogens and decreased beneficial bacteria.
- Additionally, the study indicated rising antibiotic resistance among rehabilitated birds, specifically against common antibiotics, which may hinder their adaptability to natural environments post-release.
Global spread of strains carrying the mobilized colistin resistance gene (MCR1-EC) poses serious threats to public health. Colistin has been generally prescribed for swine colibacillosis, having made swine farms as major reservoirs of MCR1-EC. The present study aimed to understand characteristic differences of MCR1-EC, including prevalence, antimicrobial resistance, and virulence, according to swine production stages.
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- * Researchers tested this method by simulating 100 HBP cases, taking into account different reading counts (16, 20, 24) and standard deviations (5, 10, 15, 20), achieving high accuracy in determining uncontrolled HBP.
- * Validation using real HBP data showed high C-statistics and a favorable count-to-total BP reading ratio, indicating the method effectively assesses HBP control with high sensitivity and specificity.