CMOS Single-Photon Avalanche Diode Circuits for Probabilistic Computing.

Intrinsically random hardware devices are increasingly attracting attention for their potential use in probabilistic computing architectures. One such device is the single-photon avalanche diode (SPAD) and an associated functional unit, the variable-rate SPAD circuit (VRSC), recently proposed by us as a source of randomness for sampling and annealing Ising and Potts models. This work develops a more advanced understanding of these VRSCs by introducing several VRSC design options and studying their tradeoffs as implemented in a 65-nm CMOS process.

Enhancement of NK cytotoxicity, antimetastasis and elongation effect of survival time in B16-F10 melanoma cells by oregonin.

We investigated the antitumor activity of oregonin, a diarylheptanoid derivative purified from Alnus hirsuta Turcz, Betulaceae. Oregonin is a potential novel immunomodulator, which augments the activation of natural killer (NK) cells, and thereby leads to a powerful antitumor activity. To evaluate the cytotoxicity of oregonin against tumor cells, we examined the effectiveness of NK cells and determined that oregonin could increase NK cell cytotoxicity.