Cough-induced severe bradycardia and syncope in a dog.

A 10-year-old spayed female shih tzu dog was brought to the hospital because of recurring syncope that occurred simultaneously with a cough. Physical examination did not reveal an abnormal heart rhythm or abnormal heart sounds. Electrocardiography revealed sinus arrest of 4.

MR-GGI: accurate inference of gene-gene interactions using Mendelian randomization.

Background: Researchers have long studied the regulatory processes of genes to uncover their functions. Gene regulatory network analysis is one of the popular approaches for understanding these processes, requiring accurate identification of interactions among the genes to establish the gene regulatory network. Advances in genome-wide association studies and expression quantitative trait loci studies have led to a wealth of genomic data, facilitating more accurate inference of gene-gene interactions.

Numerical modeling of sneeze airflow and its validation with an experimental dataset.

In this study, we aimed at providing datasets using experimental results to validate the sneeze airflow. In addition, the boundary conditions for the sneeze simulation that could reproduce the sneeze airflow in the experimental results are presented and reviewed. The validation datasets were created by performing ensemble-average analysis with the experimental results of particle image velocimetry, and these were used to explore the boundary conditions to reproduce the sneeze airflow.

Effects of Environmental Features in Small Public Urban Green Spaces on Older Adults' Mental Restoration: Evidence from Tokyo.

Exposure to small public urban green spaces (SPUGS) has been demonstrated to have mental benefits for older adults. However, studies on identifying the objective environmental features of SPUGS and their effects on mental restoration for older adults remain limited. This study employed a multilevel regression model to investigate the restorative and vitalizing effects of the environmental features of 11 SPUGS in Tokyo.

Lemon Balm and Corn Silk Mixture Alleviates Metabolic Disorders Caused by a High-Fat Diet.

We recently reported that varying combination ratios of lemon balm ( L.) and corn silk extracts (Stigma of L. fruit) could reduce the obesity caused by a high-fat diet (HFD).

Amlodipine decreases mitral regurgitation volume in dogs over 7 days: A study of 24 dogs with myxomatous mitral valve degeneration.

Background: Amlodipine, a dihydropyridine calcium-channel blocker, is currently being investigated as a treatment for myxomatous mitral valvular degeneration (MMVD). However, the effects of amlodipine on moderate or severe spontaneous MMVD, based on changes in echocardiographic indices, remain unclear.

Animals: Client-owned small-breed dogs ( = 24) with naturally occurring MMVD of the American College of Veterinary Internal Medicine (ACVIM) stage B2 or higher.

Lemon Balm and Corn Silk Extracts Mitigate High-Fat Diet-Induced Obesity in Mice.

Lemon balm and corn silk are valuable medicinal herbs, which exhibit variety of beneficial effects for human health. The present study explored the anti-obesity effects of a mixture of lemon balm and corn silk extracts (M-LB/CS) by comparison with the effects of single herbal extracts in high-fat diet (HFD)-induced obesity in mice. HFD supplementation for 84 days increased the body weight, the fat mass density, the mean diameter of adipocytes, and the thickness of fat pads.

Experimental measurements of airflow features and velocity distribution exhaled from sneeze and speech using particle image velocimetry.

Airflow exhaled from sneeze and speech is an important source of viruses and droplets in daily life and may cause imperceptible virus propagation. The velocities of sneeze and speech airflow exhaled from 10 healthy young participants repeatedly using high-frequency (2986 Hz) particle image velocimetry are measured. The parameters for describing the dynamic process of sneeze airflow, such as sneeze duration time (SDT), peak velocity time (PVT), maximum velocities, and sneeze spread angle, are analyzed.

Recent research on expiratory particles in respiratory viral infection and control strategies: A review.

The global spread of coronavirus disease 2019 poses a significant threat to human health. In this study, recent research on the characteristics of expiratory particles and flow is reviewed, with a special focus on different respiratory activities, to provide guidance for reducing the viral infection risk in the built environment. Furthermore, environmental influence on particle evaporation, dispersion, and virus viability after exhalation and the current methods for infection risk assessment are reviewed.

Measurements of exhaled airflow velocity through human coughs using particle image velocimetry.

The sudden outbreak of coronavirus (COVID-19) has infected over 100 million people and led to over two million deaths (data in January 2021), posing a significant threat to global human health. As a potential carrier of the novel coronavirus, the exhaled airflow of infected individuals through coughs is significant in virus transmission. The research of detailed airflow characteristics and velocity distributions is insufficient because most previous studies utilize particle image velocimetry (PIV) with low frequency.

Experimental assessment of convective and radiative heat transfer coefficients for various clothing ensembles.

The convective and radiative heat transfer coefficients of clothing are important parameters for human thermoregulation and comfort models. Many researchers have studied convective and radiative heat transfer coefficients of the naked human body. However, there is limited information on convective and radiative heat transfer coefficients for the clothed human body.

Protective effects of fermented rice extract on ulcerative colitis induced by dextran sodium sulfate in mice.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), characterized by the gut mucosal ulceration. Growing evidence indicates that dysregulation of immune response to the commensal microbiota involves the pathogenesis of IBD. Previous studies have demonstrated the favorable probiotic effects of fermented rice extracts through triple fermentation with and (FRe).

Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice.

Ultraviolet (UV) B exposure induces DNA damage and production of reactive oxygen species (ROS), which causes skin photoaging through signaling pathways of inflammation and modulation of extracellular matrix remodeling proteins, collagens, and matrix metalloproteinase (MMP). As low molecular-weight fucoidan (LMF) has potential antioxidant and anti-inflammatory properties, we examined the protective effects of LMF against UVB-induced photoaging. A UVB-irradiated mouse model was topically treated with myricetin or LMF at 2.

Recurrent sebaceous carcinoma in an African hedgehog (Atelerix albiventris).

A 1.5-year-old intact male African hedgehog (Atelerix albiventris) was presented with a firm, non-movable subcutaneous mass on ventral chest area. Microscopically, the tumor was un-encapsulated, invasive up to the muscle layer, and composed of highly pleomorphic polygonal cells arranged in variably-sized lobules.

Mapping of the dog skin based on biophysical measurements.

Trans epidermal water loss (TEWL), skin hydration status and pH were determined in 14 skin regions of five healthy male Beagle dogs (2-4 years) both before and after anaesthesia. Trans epidermal water loss was highest for the footpad and head and lowest for the inguinal region. Skin hydration status was higher in the ear but did not vary significantly in other regions.