Publications by authors named "Wong Wanling"
Background: Amlitelimab, a fully human nondepleting mAb targeting OX40 ligand on antigen-presenting cells, could prevent T-cell-driven inflammation seen in atopic dermatitis (AD).
Objective: This trial evaluated the efficacy and safety of amlitelimab in adults with AD.
Methods: In this 2-part, phase 2b, randomized, double-blinded placebo-controlled trial (ClinicalTrials.
Background: More than half of patients with polymyalgia rheumatica have a relapse during tapering of glucocorticoid therapy. Previous studies have suggested that interleukin-6 blockade may be clinically useful in the treatment of polymyalgia rheumatica. Sarilumab, a human monoclonal antibody, binds interleukin-6 receptor α and efficiently blocks the interleukin-6 pathway.
View Article and Find Full Text PDFPurpose: To evaluate the performance of polypoidal choroidal vasculopathy (PCV) diagnosis using fundus camera-based indocyanine green angiography, comparing a single sign of "subretinal focal hyperfluorescence" on indocyanine green angiography with a modification of the EVEREST criteria.
Methods: Color fundus photograph, flash fundus camera-based fluorescein angiography, and indocyanine green angiography of 241 eyes of 230 consecutive patients with exudative maculopathy due to PCV or typical age-related macular degeneration were graded independently by 2 retinal specialists using a modified EVEREST criteria, which requires the presence of subretinal focal hyperfluorescence plus any 1 of 5 additional criteria. Discordant cases were adjudicated by a senior retinal specialist to arrive at the final diagnosis.
Objective: To examine the reliability of inexperienced observers in plotting optic disc contours on Heidelberg retinal tomography images before and after training.
Design: Observational study.
Participants: One hundred eyes that were randomly selected from the Singapore Indian Eye Study.
Purpose: We hypothesize that patients with primary angle closure (PAC) have common significant facial characteristics that set them apart from an age-matched, sex-matched, and race-matched control population. The primary objective of this study was to test whether a 3-dimensional (3D) camera could pick up these differences in order to differentiate PAC patients from controls.
Patients: A total of 55 patients with PAC and 38 controls were included in the study.
Purpose: To assess the efficacy of intravitreal 0.5 mg ranibizumab for the treatment of center-involving macular edema secondary to branch retinal vein occlusion (BRVO) over 1 year compared with standard-of-care grid laser.
Design: A prospective randomized controlled clinical trial.
Purpose: To determine the prevalence and types of glaucoma in an urban Singaporean Indian population.
Methods: The Singapore Indian Eye Study (SINDI) was a population-based, cross-sectional survey that examined 3400 (75.6% response) persons aged 40 to 80 years.
Introduction: To describe the optic disc, visual field and ocular characteristics of a consecutive cohort of Asian patients with chronic primary angle-closure glaucoma (CPACG), and compare them with those having primary open-angle glaucoma (POAG).
Methods: In a prospective comparative case series of new patients with POAG or CPACG in Singapore, all patients underwent visual acuity assessment, slit-lamp examination, tonometry, gonioscopy, refraction, Heidelberg Retina Tomograph (HRT) and Humphrey visual field (HVF) assessment.
Results: 98 patients were enrolled (POAG n = 48; CPACG n = 50).
Introduction: We compared the agreement of diabetic retinopathy (DR) assessment between trained non-physician graders (NPGs) and family physicians (FPs) in a primary healthcare setting.
Methods: This was a cross-sectional study conducted retrospectively over a period of one month. The participants were diabetic patients from two primary healthcare clinics (polyclinics) in Singapore.
Purpose: The objective of this study was to evaluate the features, timing of intervention, complications, and outcomes of patients who underwent surgery for pediatric orbital blow-out fractures.
Design: This was a retrospective case review studying all cases of pediatric orbital blow-out fractures that underwent surgical intervention from 2000 to 2009 in a tertiary ophthalmic center in Singapore.
Methods: Case notes review of all cases of pediatric orbital blow-out fractures repaired surgically was carried out for demographics, time to intervention, and outcome.
Purpose: To determine the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT).
Methods: Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry.
Background: To evaluate different mechanisms of primary angle closure and to quantify anterior chamber parameters in these mechanisms using anterior segment optical coherence tomography in an Asian population.
Design: Hospital-based cross-sectional observational study.
Participants: Forty-eight consecutive patients with primary angle closure glaucoma.
Purpose: To describe the prevalence and risk factors of pterygium in a multiethnic Asian population and to examine racial differences.
Design: Population-based study in Singapore, located 1° north of the equator.
Participants: Data were analyzed from 8906 participants from 3 population-based studies of Malays, Indians, and Chinese persons 40 years of age and older conducted between 2004 and 2011.
Background: To describe the rationale and study design of a follow-up epidemiological eye study among Singaporean Malay adults.
Design: Follow-up prospective population-based study.
Participants: Participants of the Singapore Malay Eye Study (SiMES-1), which was conducted from August 2004 to June 2006.
Prevalence and risk factors of epiretinal membrane in Asian Indians.
Invest Ophthalmol Vis Sci
February 2012
Purpose: To describe the prevalence of epiretinal membrane (ERM) and its risk factors in an Indian population and compare the findings with other populations.
Methods: The Singapore Indian Eye Study is a population-based survey of 3400 Asian Indians aged between 40 and 80 years. A comprehensive ophthalmic examination, standardized interviews, and laboratory blood tests were performed.
The prevalence and risk factors of ocular trauma: the Singapore Indian eye study.
Ophthalmic Epidemiol
December 2011
Purpose: To describe the prevalence and risk factors of ocular trauma in an urban Southeast Asian population.
Methods: A population-based survey of 3,400 (75.6% response rate) adults of Indian ethnicity aged 40-80 years residing in Singapore was conducted in 2007-2009.
Purpose: Our previous study, Atropine for the Treatment of Myopia 1 (ATOM1), showed that atropine 1% eyedrops were effective in controlling myopic progression but with visual side effects resulting from cycloplegia and mydriasis. The aim of this study was to compare efficacy and visual side effects of 3 lower doses of atropine: 0.5%, 0.
View Article and Find Full Text PDFPurpose: To compare the prevalence and risk factors of diabetes (DM) and diabetic retinopathy (DR) in a multi-ethnic Asian population of Chinese, Malays, and Indians in Singapore.
Methods: A total of 2919 individuals participated in a population-based, cross-sectional study in Singapore of Chinese (n = 1633), Malays (n = 658), and Indians (n = 628) aged 40 to 95 years, with retinal photographs, graded using the Early Treatment Diabetic Retinopathy Study (ETDRS) severity scale. DM was defined as fasting plasma glucose ≥ 7 mmol/L, self-reported physician-diagnosed diabetes, and use of glucose-lowering medication.
Purpose: Cataract is the major cause of blindness worldwide yet there is no consensus on its assessment and definition. This study compares age-related cataract prevalence derived from two commonly used methods: clinical assessment using the Lens Opacity Classification System (LOCS III) and photographic grading using the Wisconsin Cataract Grading System (Wisconsin System).
Methods: The Singapore Malay Eye Study is a population-based study of 3,280 Singapore Malays aged 40-80 years.
Corneal arcus is a sign of cardiovascular disease, even in low-risk persons.
Am J Ophthalmol
November 2011
Purpose: To examine the association of corneal arcus to cardiovascular disease (CVD) in an adult, ethnic Indian population.
Design: Population-based cross-sectional study.
Methods: Population-based study of ethnic South Asian Indians 40 to 80 years of age in Singapore from June 2007 through March 2009.
Aim: To study the effect of the duration of anti-tubercular treatment (ATT) on the recurrence of uveitis associated with latent tuberculosis (TB).
Methods: Retrospective review of all consecutive uveitis patients seen at a single, tertiary institution over 9 years with uveitis consistent with TB, positive tuberculin skin test with other causes ruled out, and a minimum of 6 months follow-up after completion of treatment. Clinical characteristics, treatment type, treatment duration and clinical response were recorded.
Purpose: To examine the correlation and agreement of stereometric parameters between Heidelberg Retinal Tomograph version 2 (HRT-2) and HRT-3 in a normal Asian population.
Methods: This was a population-based study using data from the Singapore Malay Eye Study. Participants underwent a standardized and complete ophthalmic examination.
Background: To describe the changes in retinal vascular calibre in response to intravitreal ranibizumab injections in patients with neovascular age-related macular degeneration.
Design: Prospective interventional case series.
Participants: Treatment naïve patients with neovascular age-related macular degeneration were recruited over a 1-year period.
Purpose: To describe the prevalence and causes of visual impairment and blindness in an urban Indian population.
Design: Population-based study.
Participants: Ethnic Indians aged more than 40 years living in Singapore.