Publications by authors named "Wong Hallee"

The provision of ART in South Africa has transformed the HIV epidemic, resulting in an increase in life expectancy by over 10 years. Despite this, nearly 2 million people living with HIV are not on treatment. The objective of this study was to develop and externally validate a practical risk assessment tool to identify people with HIV (PWH) at highest risk for attrition from care after testing.

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The effect of gestational age (GA) on comorbidity prevalence, healthcare resource utilization (HCRU), and all-cause costs is significant for extremely premature (EP) infants in the United States. To characterize real-world patient characteristics, prevalence of comorbidities, rates of HCRU, and direct healthcare charges and societal costs among premature infants in US Medicaid programs, with respect to GA and the presence of respiratory comorbidities. Using codes, diagnosis and medical claims data from 6 state Medicaid databases (1997-2018) of infants born at less than 37 weeks of GA (wGA) were collected retrospectively.

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Background: Infants born extremely premature (EP) (<28 weeks gestational age) are at high risk of complications, particularly bronchopulmonary dysplasia (BPD), which can develop into chronic lung disease (CLD).

Methods: The burden of respiratory complications in EP infants up to 2 years corrected age (CA) was evaluated using real-world data from the US Medicaid program. Data recorded between 1997 and 2018 on EP infants without major congenital malformations were collected from Medicaid records of six states.

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Article Synopsis
  • Using real-world data (RWD) and natural history data (NHD) for evaluating drugs in Duchenne muscular dystrophy (DMD) offers a solution to the difficulties of enrolling participants in placebo-controlled trials.
  • A study compared the changes in the North Star Ambulatory Assessment (NSAA) scores between placebo trial arms and RWD/NHD data, revealing that the differences were minor before and after adjusting for baseline factors.
  • The findings suggest that RWD/NHD external controls are appropriate for DMD drug evaluations, as they align with earlier results and provide a solid method for accounting for prognostic factors.
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