Publications by authors named "Wondzinski E"
Article Synopsis
- The study investigated cognitive impairments in cerebellar disorders and identified two subtypes of cerebellar cognitive affective syndrome (CCAS) using cluster analysis.
- The German CCAS-Scale was utilized to assess 205 cerebellar patients and 200 controls, revealing one cluster with severe cognitive impairment and another with milder deficits that often overlapped with healthy controls.
- Findings suggest that cognitive performance in cerebellar patients is influenced by both demographic factors and cluster assignment, indicating that the assessment tool may struggle to detect milder impairments.
Background: Traditionally, cerebellar disorders including ataxias have been associated with deficits in motor control and motor learning. Since the 1980's growing evidence has emerged that cerebellar diseases also impede cognitive and affective processes such as executive and linguistic functions, visuospatial abilities and regulation of emotion and affect. This combination of non-motor symptoms has been named .
View Article and Find Full Text PDFIn the present study extinction and renewal of cognitive associations were assessed in two experiments in participants with focal and degenerative cerebellar disease. Using a predictive learning task, participants had to learn by trial and error the relationships between food items and the occurrence of stomach trouble in a hypothetical patient. In the first experiment, focus was on renewal effects.
View Article and Find Full Text PDFExtinction of conditioned aversive responses (CR) has been shown to be context-dependent. The hippocampus and prefrontal cortex are of particular importance. The cerebellum may contribute to context-related processes because of its known connections with the hippocampus and prefrontal cortex.
View Article and Find Full Text PDFArticle Synopsis
- - Studies using modern techniques show that different areas of the cerebellum are important for adapting movements, specifically in response to force fields and visual changes during reaching tasks.
- - The research focused on patients with cerebellar lesions, revealing that the superior hand area is critical for both types of adaptations, while the inferior hand area did not show significant involvement.
- - Findings suggest that lobule V is key for adapting to force fields, whereas lobule VI is more important for visual movement adaptations, indicating distinct functions within the cerebellum.
Age effects in storage and extinction of a naturally acquired conditioned eyeblink response.
Neurobiol Learn Mem
March 2014
Acquisition of conditioned eyeblink responses is known to decline with age, and age-related decline has been related to a reduction of cerebellar size and function. The aim of the present study was to investigate age-related effects on storage-related processes and extinction of visual threat eyeblink responses (VTERs), conditioned responses which are naturally acquired in early childhood. Storage and extinction of VTERs were tested in 34 healthy participants with an age range from 21 to 74 years (mean age 41.
View Article and Find Full Text PDFPrevious findings suggested that the human cerebellum is involved in the acquisition but not the long-term storage of motor associations. The finding of preserved retention in cerebellar patients was fundamentally different from animal studies which show that both acquisition and retention depends on the integrity of the cerebellum. The present study investigated whether retention had been preserved because critical regions of the cerebellum were spared.
View Article and Find Full Text PDFExtent of cerebellar involvement in cognition and emotion is still a topic of ongoing research. In particular, the cerebellar role in humor processing and control of laughter is not well known. A hypermetric dysregulation of affective behavior has been assumed in cerebellar damage.
View Article and Find Full Text PDFBackground And Purpose: Obstructive sleep apnea (OSA) is suspected to be an independent risk factor for atherosclerotic artery disease. The aim of this hospital-based case-control study was to assess the association between OSA and extracranial artery disease (EAD) as well as peripheral artery disease (PAD) in stroke survivors adjusting for potential confounders.
Methods: Out of 395 stroke survivors in reconvalescent phase, 235 (male 165, female 70, mean age 64.