Publications by authors named "Won-Jun Lim"
Article Synopsis
- Autism spectrum disorder (ASD) is influenced by both genetic and environmental factors, with many ASD-associated genes yet to be discovered, prompting this study to explore rare de novo variants in a Korean familial dataset.
- Using whole exome sequencing (WES) and bioinformatics, researchers analyzed 151 individuals from 51 families, identifying 36 de novo variants potentially linked to ASD.
- The study revealed functional networks related to ASD, particularly highlighting the NF-κB signaling pathway, while cautioning that the small sample size may limit the findings on novel ASD genes.
Article Synopsis
- Genome-wide association studies (GWAS) have helped identify key markers that influence complex traits in plants, particularly focusing on flowering time in soybeans.
- Researchers genotyped 2,662 soybean accessions using a specialized SNP array, uncovering 93 significant SNP markers linked to flowering time, including important genes E1 and E3.
- Further analysis revealed 18 candidate SNP markers involved in multilocus epistatic interactions, offering new insights and potential tools for breeding programs aimed at regulating flowering time in soybeans.
Background: Domestication and improvement processes, accompanied by selections and adaptations, have generated genome-wide divergence and stratification in soybean populations. Simultaneously, soybean populations, which comprise diverse subpopulations, have developed their own adaptive characteristics enhancing fitness, resistance, agronomic traits, and morphological features. The genetic traits underlying these characteristics play a fundamental role in improving other soybean populations.
View Article and Find Full Text PDFIndigenous breeds develop their own genomic characteristics by adapting to local environments or cultures over long periods of time. Most of them are not particularly productive in commercial terms, but they have abilities to survive in harsh environments or tolerate to specific diseases. Their adaptive characteristics play an important role as genetic materials for improving commercial breeds.
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- The crab-eating monkey is a key subject in biomedical research, especially for studying pharmacological effects and understanding epigenetic regulation in primate brains through DNA methylation.
- Researchers generated RNA-seq and whole-genome bisulfite sequencing data to explore correlations between gene expression and DNA methylation across seven different brain regions in a single monkey, identifying 92 genes with significant relationships.
- Among the identified genes, some were linked to brain and eye functions, and a couple were recognized as brain epigenetic markers, demonstrating the complex roles of DNA methylation in adult brain tissues.
DNA methylation is an epigenetic mark that plays an essential role in regulating gene expression. CpG islands are DNA methylations regions in promoters known to regulate gene expression through transcriptional silencing of the corresponding gene. DNA methylation at CpG islands is crucial for gene expression and tissue-specific processes.
View Article and Find Full Text PDFFemale fertility is a highly regulated process involving the synchronized activities of multiple tissues. The underlying genomic regulation of the tissue synchronization is poorly understood. To understand this better we investigated the transcriptomes of the porcine ovary, endometrium, and oviduct at days 0, 3, 6, 9, 12, 15, or 18 of the oestrous cycle.
View Article and Find Full Text PDFHuman mitochondrial transcription factor A (TFAM) has been implicated in promoting tumor growth and invasion. TFAM activates mitochondrial DNA (mtDNA) transcription, and affects nuclear gene expression through mitochondrial retrograde signaling. In this study, we investigated the effects of TFAM depletion on the morphology and transcriptome of MKN45 gastric cancer cells.
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- * Researchers performed whole-genome resequencing of 17 radish accessions (10 cultivated and 7 wild) and found 4 million high-quality SNPs, revealing that Asian cultivated radishes are closely related to their wild counterparts, highlighting unique domestication pathways compared to European/American radishes.
- * The analysis identified 153 candidate domestication regions with genes linked to root development, signaling pathways, and metabolism, suggesting that traits like a main taproot and better taste resulted from selective breeding in radishes
Article Synopsis
- Hanwoo and Yanbian are related cattle breeds from Korea and China, respectively, with a shared ancestor until the last century when they faced different selection pressures.
- A study identified 901 copy number variation regions (CNVRs) in the genomes of both breeds by analyzing approximately 3.12 billion sequence reads from Hanwoo and 3.07 billion from Yanbian cattle.
- The analysis revealed that over half of the CNVRs were gains in Hanwoo, with many overlapping with genes linked to important traits, providing insights that could help in improving cattle breeding practices.