Publications by authors named "Won Young Chey"
Those who dye their hair frequently manifest allergic contact dermatitis (ACD) from p-phenylenediamine (PPD)-containing hair dye. PPD is known to be the most frequent sensitizer in hair dye, but there has been no documentation of this sensitizer having a role in chronic dermatologic conditions. Our department experienced a case of a 62-year-old woman with lichen simplex chronicus (LSC), who complained of aggravation after hair dyeing and made such an association.
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- A lack or mutation in metabolic enzymes, specifically the CYP2C9 gene, may lead to cutaneous adverse drug reactions (CADRs) from diphenylhydantoin (DPH), and patch testing is often ineffective for these reactions.
- Three out of ten patients with DPH-induced CADRs exhibited a heterozygous CYP2C9*3 variant, which significantly increased their odds of adverse reactions compared to other groups.
- This variant appears to differentiate CADR patients with positive patch-test results from those without, highlighting its potential role in adverse drug reactions related to DPH.
Article Synopsis
- The effectiveness of skin tests for diagnosing adverse drug reactions (ADRs) is limited due to a lack of understanding of drug allergens.
- Reports suggest that metabolites, particularly a carbamazepine (CBZ) metabolite, play a significant role in skin reactions.
- In a study, skin tests with CBZ and its metabolite CBZ-epoxide showed positive results in 10 out of 13 patients with CBZ-induced skin reactions, highlighting the importance of testing both drugs and their metabolites for better diagnostic accuracy.
Allergic reaction to insulin preparations seemed to have decreased since the introduction of contaminant-free, human preparations. The role of protamine sulfate in decreasing the prevalence of allergy is unclear. This study examines the causative components of insulin allergy along with the value of skin tests for diagnosis.
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