Combined topical fluconazole and corticosteroid treatment for experimental Candida albicans keratomycosis.

Purpose: To determine the most efficient time point and concentration of topical corticosteroids in Candida albicans keratitis treated with fluconazole.

Methods: Corneas of 105 rabbits were infected with viable yeast cells of C. albicans (2.

Excimer laser "corneal shaping": a new technique for customized trephination in penetrating keratoplasty. First experimental results in rabbits.

Purpose: The aim of the presented experimental work was to develop a technique for congruent trephination of donor and recipient corneas in free form using a 193-nm excimer laser and to study the clinical follow-up after the application of the technique in a rabbit model.

Methods: In 12 New Zealand White rabbits homologous penetrating keratoplasty was performed. Trephination of donor buttons and recipient beds was achieved in six animals by conventional mechanical trephination and in six by excimer laser trephination with a guided laser beam in a non-circular geometry.