Effect of tibolone compared with sequential hormone replacement therapy on carbohydrate metabolism in postmenopausal women.

Objective: To investigate the effects of tibolone on carbohydrate metabolism, and to compare these effects with those of a sequential regimen of conjugated equine estrogens and medrogestone.

Methods: This was an open-label, multicentre, comparative study. Seventy-two postmenopausal women were randomized to receive either tibolone 2.