A Clinically Validated, Broadly Active, Oral Viral Superinfection Therapy Could Mitigate Symptoms in Early-stage COVID-19 Patients.

More than 200 viruses infect humans, but treatments are available for less than ten of them. To narrow the gap between 'bugs and drugs,' a paradigm shift is required. The "one drug, one bug" approach can be expanded to a "one drug, multiple bugs" strategy such that the host's defense system is targeted rather than the virus.

Skin sodium measured with ²³Na MRI at 7.0 T.

Skin sodium (Na(+) ) storage, as a physiologically important regulatory mechanism for blood pressure, volume regulation and, indeed, survival, has recently been rediscovered. This has prompted the development of MRI methods to assess Na(+) storage in humans ((23) Na MRI) at 3.0 T.

Modular 32-channel transceiver coil array for cardiac MRI at 7.0T.

Purpose: To design and evaluate a modular transceiver coil array with 32 independent channels for cardiac MRI at 7.0T.

Methods: The modular coil array comprises eight independent building blocks, each containing four transceiver loop elements.

Detailing radio frequency heating induced by coronary stents: a 7.0 Tesla magnetic resonance study.

The sensitivity gain of ultrahigh field Magnetic Resonance (UHF-MR) holds the promise to enhance spatial and temporal resolution. Such improvements could be beneficial for cardiovascular MR. However, intracoronary stents used for treatment of coronary artery disease are currently considered to be contra-indications for UHF-MR.

Two-dimensional sixteen channel transmit/receive coil array for cardiac MRI at 7.0 T: design, evaluation, and application.

Purpose: To design, evaluate, and apply a 2D 16-channel transmit/receive (TX/RX) coil array tailored for cardiac magnetic resonance imaging (MRI) at 7.0 T.

Materials And Methods: The cardiac coil array consists of two sections each using eight elements arranged in a 2 × 4 array.

Comparison of three multichannel transmit/receive radiofrequency coil configurations for anatomic and functional cardiac MRI at 7.0T: implications for clinical imaging.

Objectives: To implement, examine, and compare three multichannel transmit/receive coil configurations for cardiovascular MR (CMR) at 7T.

Methods: Three radiofrequency transmit-receive (TX/RX) coils with 4-, 8-, and 16-coil elements were used. Ten healthy volunteers (seven males, age 28 ± 4 years) underwent CMR at 7T.

Detailing the use of magnetohydrodynamic effects for synchronization of MRI with the cardiac cycle: a feasibility study.

Purpose: To investigate the feasibility of using magnetohydrodynamic (MHD) effects for synchronization of magnetic resonance imaging (MRI) with the cardiac cycle.

Materials And Methods: The MHD effect was scrutinized using a pulsatile flow phantom at B(0) = 7.0 T.

(23)Na magnetic resonance imaging of tissue sodium.

Hypertension is linked to disturbed total-body sodium (Na(+)) regulation; however, measuring Na(+) disposition in the body is difficult. We implemented (23)Na magnetic resonance spectroscopy ((23)Na-MR) and imaging technique ((23)Na-MRI) at 9.4T for animals and 3T for humans to quantify Na(+) content in skeletal muscle and skin.

Comparison of peritoneal adhesion formation in bowel retraction by cotton towels versus the silicone lap pak device in a rabbit model.

Objective: Manipulation of cotton operating room towels within the abdominal cavity in open abdominal surgery has been associated with the formation of peritoneal adhesions. In a rabbit model, the use of standard cotton operating room towels is compared to the Lap Pak, a silicone bowel-packing device, to determine the potential for reducing the risk of adhesions.

Methods: Thirty rabbits were randomly assigned to 3 groups.

Design, evaluation and application of an eight channel transmit/receive coil array for cardiac MRI at 7.0 T.

The objective of this work is to design, examine and apply an eight channel transmit/receive coil array tailored for cardiac magnetic resonance imaging at 7.0 T that provides image quality suitable for clinical use, patient comfort, and ease of use. The cardiac coil array was designed to consist of a planar posterior section and a modestly curved anterior section.

Development and evaluation of a small and mobile Magneto Alert Sensor (MALSE) to support safety requirements for magnetic resonance imaging.

Objective: The purpose of this study is to (i) design a small and mobile Magnetic field ALert SEnsor (MALSE), (ii) to carefully evaluate its sensors to their consistency of activation/deactivation and sensitivity to magnetic fields, and (iii) to demonstrate the applicability of MALSE in 1.5 T, 3.0 T and 7.

Design and application of a four-channel transmit/receive surface coil for functional cardiac imaging at 7T.

Purpose: To design and evaluate a four-channel cardiac transceiver coil array for functional cardiac imaging at 7T.

Materials And Methods: A four-element cardiac transceiver surface coil array was developed with two rectangular loops mounted on an anterior former and two rectangular loops on a posterior former. specific absorption rate (SAR) simulations were performed and a B 1+ calibration method was applied prior to obtain 2D FLASH CINE (mSENSE, R = 2) images from nine healthy volunteers with a spatial resolution of up to 1 × 1 × 2.

Acoustic cardiac triggering: a practical solution for synchronization and gating of cardiovascular magnetic resonance at 7 Tesla.

Background: To demonstrate the applicability of acoustic cardiac triggering (ACT) for imaging of the heart at ultrahigh magnetic fields (7.0 T) by comparing phonocardiogram, conventional vector electrocardiogram (ECG) and traditional pulse oximetry (POX) triggered 2D CINE acquisitions together with (i) a qualitative image quality analysis, (ii) an assessment of the left ventricular function parameter and (iii) an examination of trigger reliability and trigger detection variance derived from the signal waveforms.

Results: ECG was susceptible to severe distortions at 7.

Cardiac chamber quantification using magnetic resonance imaging at 7 Tesla--a pilot study.

Objectives: Interest in cardiovascular magnetic resonance (CMR) at 7 T is motivated by the expected increase in spatial and temporal resolution, but the method is technically challenging. We examined the feasibility of cardiac chamber quantification at 7 T.

Methods: A stack of short axes covering the left ventricle was obtained in nine healthy male volunteers.

Degenerate mode band-pass birdcage coil for accelerated parallel excitation.

An eight-rung, 3T degenerate birdcage coil (DBC) was constructed and evaluated for accelerated parallel excitation of the head with eight independent excitation channels. Two mode configurations were tested. In the first, each of the eight loops formed by the birdcage was individually excited, producing an excitation pattern similar to a loop coil array.