Publications by authors named "Wolfgang Leonhardt"
Article Synopsis
- Pioglitazone and simvastatin were studied individually and in combination to see their effects on LDL subfractions in non-diabetic patients at high cardiovascular risk.
- Simvastatin effectively lowered cholesterol in certain LDL subfractions (IDL, LDL1, LDL2) but had no impact on LDL3, while pioglitazone specifically reduced cholesterol levels in LDL3.
- The combination therapy of both drugs led to even greater reductions in LDL3 cholesterol and particle number compared to either treatment alone, indicating potential synergistic benefits.
Glucagon is the physiological antagonist of insulin. Postprandial (pp) hyperglycemia in impaired glucose tolerance (IGT) and in type 2 diabetes mellitus (T2DM) may also depend on irregularities in glucagon secretion. This study investigated the glucagon excursion after a lipid-glucose-protein tolerance test in subjects with different stages of glucose intolerance.
View Article and Find Full Text PDFA mutation in the peroxisome proliferator-activated receptor gamma2 (PPARgamma2) gene with a cytosine to guanine substitution results in an exchange of proline (Pro) with alanine (Ala) in exon B (codon 12) of this gene. This polymorphism has been associated with high insulin sensitivity and low body weight, but no data have been published to date about its effect on early atherosclerosis. We investigated the relationship of the Pro(12)Ala polymorphism to early atherosclerosis, measured by the intima-media thickness (IMT).
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