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Digital care applications are digital solutions that should improve or stabilise the health of people in need of care and thus maintain their independence. In the future, they are supposed to be increasingly used to cope with the major challenges in geriatric care, especially the shortage of caregivers. Germany has already created the legal framework for embedding digital care applications in standard care.

[Not Available].

Teletherapy enables the provision of therapy services at a distance, supported by the use of information and communication technologies (ICT), for example by means of videoconferencing. This sub-discipline of telemedicine allows, to respond and adapt to global challenges and changing health needs of the population. The Albert Schweitzer Clinic of the Geriatric Health Centers has been using teletherapeutic after-care since the outbreak of the COVID-19 pandemic.

Direct activation of antigen-presenting cells is required for CD8+ T-cell priming and tumor vaccination.

Successful priming of adaptive immune responses is crucially dependent on innate activation signals that convert resting antigen-presenting cells (APCs) into immunogenic ones. APCs expressing the relevant innate pattern recognition receptors can be directly activated by pathogen-associated molecular patterns (PAMPs) to become competent to prime T-cell responses. Alternatively, it has been suggested that APCs could be activated indirectly by proinflammatory mediators synthesized by PAMP-exposed cells.

Type I IFN substitutes for T cell help during viral infections.

Certain virus infections depend on the presence of T cell help for the generation of primary CD8(+) T cell responses. However, the mechanisms that render these particular viral infections T cell help dependent is largely unknown. In this study, we compared CD8(+) T cell responses elicited by lymphocytic choriomeningitis virus infection, as prototype of a T cell help independent infection, with T cell help dependent CD8(+) T cell responses induced by vaccinia virus infection.

Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL.

Phosphorylation of transcription factor STAT-1 on Y701 regulates subcellular localization whereas phosphorylation of the transactivating domain at S727 enhances transcriptional activity. In this study, we investigate the impact of STAT-1 and the importance of transactivating domain phosphorylation on the induction of peptide-specific CTL in presence of the TLR9-dependent immune adjuvant IC31. STAT-1 deficiency completely abolished CTL induction upon immunization, which was strongly reduced in animals carrying the mutation of the S727 phospho-acceptor site.