Drug induced interstitial lung disease.

With an increasing number of therapeutic drugs, the list of drugs that is responsible for severe pulmonary disease also grows. Many drugs have been associated with pulmonary complications of various types, including interstitial inflammation and fibrosis, bronchospasm, pulmonary edema, and pleural effusions. Drug-induced interstitial lung disease (DILD) can be caused by chemotherapeutic agents, antibiotics, antiarrhythmic drugs, and immunosuppressive agents.

Cytochrome P450 polymorphisms and drug-induced interstitial lung disease.

Introduction: With an increasing number of therapeutic drugs available for use, the list of drugs that are responsible for severe pulmonary disease also grows. Genetic polymorphism of drug-metabolizing enzymes, particularly of the cytochrome P450 superfamily of enzymes, influences individual drug efficacy and safety through the alteration of pharmacokinetics and disposition of drugs.

Areas Covered: This review focuses on drug-induced interstitial lung disease, describes common patterns of pulmonary injury, discusses diagnosis and treatment, and details the prevalence and clinical significance of cytochrome P450 polymorphisms.