Publications by authors named "Wolf-Ulrich Brewer"
Article Synopsis
- The study investigates the effects of triheptanoin, a medium-chain triglyceride, on lipolysis and fatty acid metabolism in rats, particularly for treating long-chain fatty acid oxidation disorders.
- The infusion of triheptanoin leads to increased glycerol turnover without harmful long-chain fatty acid release, indicating balanced metabolism.
- Results suggest that triheptanoin could be a viable treatment option for patients experiencing metabolic crises related to these disorders.
Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats.
Renée P Kinman Takhar Kasumov Kathryn A Jobbins Katherine R Thomas Jillian E Adams Wolf-Ulrich Brewer
Am J Physiol Endocrinol Metab
October 2006
A new chronic treatment for inherited disorders of long-chain fatty acid oxidation involves administering up to one-third of dietary calories as triheptanoin, a medium-odd-chain triglyceride (Roe CR, Sweetman L, Roe DS, David F, and Brunengraber H. J Clin Invest 110: 259-269, 2002). Heptanoate and C(5)-ketone bodies derived from its partial oxidation in liver are precursors of anaplerotic propionyl-CoA in peripheral tissues.
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