Publications by authors named "Wolf A Lagreze"
Purpose: To investigate orthokeratology-related diurnal variations in visual acuity, contrast sensitivity, mesopic (twilight) vision, and glare sensitivity, and to verify compliance with requirements for driver licensing.
Methods: In this prospective, multicenter, controlled study, fifty myopic (range, -1.00 to -4.
Article Synopsis
- The study focuses on improving the diagnosis of arteritic anterior ischemic optic neuropathy (AAION) from giant cell arteritis, which can prevent vision loss, particularly when symptoms are subtle or unreliable tests are involved.
- Researchers developed a deep learning system (DLS) to differentiate between AAION and nonarteritic anterior ischemic optic neuropathy (NAION) by analyzing color fundus images from a large international dataset involving 961 eyes from 802 patients.
- The DLS demonstrated promising performance metrics, such as area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy, validating its potential as a diagnostic tool during the acute phase.
Article Synopsis
- * New studies highlight the role of peripheral vision in slowing myopia, suggesting that multifocal lenses designed to create peripheral myopic defocus can help reduce the elongation of the eyeball, which is linked to worsening myopia.
- * Although these new lenses and contacts are generally safe and well-tolerated, ongoing research should focus on diverse populations and real-world application to ensure that the benefits in managing myopia are meaningful and applicable to different groups.
Article Synopsis
- The study focused on developing a deep learning system (DLS) to differentiate between optic disc drusen (ODD) and papilledema in digital fundus photographs, which is important for understanding different ocular conditions.
- The research involved a large dataset of over 4,500 images from multiple centers worldwide, allowing for robust training and validation of the DLS.
- Results showed the DLS performed exceptionally well, achieving high accuracy in distinguishing between ODD and various severities of papilledema, indicating its potential for clinical use in neuro-ophthalmology.
Retinopathy of prematurity in Germany over 13 years: incidences, treatment preferences and effects of national guideline changes.
Arch Dis Child Fetal Neonatal Ed
December 2024
Objective: Retinopathy of prematurity (ROP) is a leading yet avoidable cause of childhood blindness. Screening for ROP is highly effective in preventing blindness secondary to ROP. We provide epidemiological data on ROP screening and treatment in Germany since 2010 and evaluate the effects of recently adopted as well as potential future screening guideline adaptations.
View Article and Find Full Text PDFPurpose: Intracranial hypertension (IH) frequently complicates cerebral venous thrombosis (CVT). Distinct neuroimaging findings are associated with IH, yet their discriminative power, reversibility and factors favoring normalization in prospective CVT patients are unknown. We determined test performance measures of neuroimaging signs in acute CVT patients, their longitudinal change under anticoagulation, association with IH at baseline and with recanalization at follow-up.
View Article and Find Full Text PDFBackground And Objectives: Optic neuritis is the most common optic neuropathy in young adults and a frequent manifestation of multiple sclerosis. Its clinical course is pertinent to the design of visual pathway neuroprotection trials.
Methods: This is a secondary analysis of longitudinal data from the TONE trial, which included 103 patients from 12 German academic tertiary centers with acute unilateral optic neuritis as a clinically isolated syndrome and baseline high-contrast visual acuity <0.
Purpose: To determine the testability, performance, and test-retest variability (TRV) of visual acuity (VA) assessment using the Freiburg Visual Acuity Test (FrACT) compared to the LEA Symbols Test (LEA) in preschool children.
Methods: In 134 preschool children aged 3.0 to 6.
Purpose: To evaluate early detection of retinal hemangioblastomas (RHs) in von Hippel-Lindau disease (VHLD) with widefield optical coherence tomography angiography (wOCTA) compared to the standard of care in ophthalmologic VHLD screening in a routine clinical setting.
Methods: We conducted prospective comparisons of three screening methods: wOCTA, standard ophthalmoscopy, and fluorescein angiography (FA), which was performed only in uncertain cases. The numbers of detected RHs were compared among the three screening methods.
Purpose: To quantify the effects of CSF pressure alterations on intracranial venous morphology and hemodynamics in idiopathic intracranial hypertension (IIH) and spontaneous intracranial hypotension (SIH) and assess reversibility when the underlying cause is resolved.
Methods: We prospectively examined venous volume, intracranial venous blood flow and velocity, including optic nerve sheath diameter (ONSD) as a noninvasive surrogate of CSF pressure changes in 11 patients with IIH, 11 age-matched and sex-matched healthy controls and 9 SIH patients, before and after neurosurgical closure of spinal dural leaks. We applied multiparametric MRI including 4D flow MRI, time-of-flight (TOF) and T2-weighted half-Fourier acquisition single-shot turbo-spin echo (HASTE).
Purpose: To analyze changes in demographic parameters and retreatment patterns over a 10-year period in a clinical routine setting of infants with retinopathy of prematurity (ROP) requiring treatment documented in the German Retina.net ROP registry.
Design: Multicenter, noninterventional, observational registry study recruiting patients treated for ROP.
Background: In this systematic review, we address the question whether children and adolescents with developmental visual disorders benefit from computer-assisted visual training.
Methods: Systematic literature searches were carried out in three bibliographic databases (initial search in October 2021) and trial registries. Included were randomized controlled trials that evaluated the efficacy of computer-assisted visual training in children and adolescents with developmental visual disorders in comparison to no training, sham training, or conservative treatment.
Treatment With Erythropoietin for Patients With Optic Neuritis: Long-term Follow-up.
Neurol Neuroimmunol Neuroinflamm
July 2023
Background And Objective: Erythropoietin (EPO) is a candidate neuroprotective drug. We assessed its long-term safety and efficacy as an adjunct to methylprednisolone in patients with optic neuritis and focused on conversions to multiple sclerosis (MS).
Methods: The TONE trial randomized 108 patients with acute optic neuritis but without previously known MS to either 33,000 IU EPO or placebo in conjunction with 1,000 mg methylprednisolone daily for 3 days.
Article Synopsis
- Myopia is a significant cause of eye disease and vision impairment, and the AIM study seeks to evaluate the effectiveness of 0.02% atropine eye drops in slowing its progression specifically in a German population of children.
- The study is a randomized, double-blind, placebo-controlled trial involving children aged 8-12 with myopia, aiming to compare the effects of atropine 0.02% against a placebo over three years.
- Key outcomes will include changes in eye refraction and axial length, along with safety assessments, with a target enrollment of 300 participants to ensure robust results.
Glaucoma in infancy and childhood is a rare disease. An immediate diagnosis and treatment are absolutely necessary to prevent blindness of affected children. Childhood glaucoma is characterized by a heterogeneous phenotype: besides primary congenital glaucoma, secondary types often exist and the individualized treatment requires an experienced interdisciplinary team.
View Article and Find Full Text PDFPurpose: Single center study to evaluate the incidence and long-term outcome of laser pointer maculopathy (LPM).
Methods: Medical records of 909,150 patients visiting our institution between 2007 and 2020 were screened in our electronic patient record system using the keywords "laserpointer," "laser pointer," and "solar."
Results: Eight patients (6/2 male/female, 11 eyes) with a history of LPM were identified by fundoscopy and optical coherence tomography (OCT), all of whom were children (6/2 male/female).
Since the retina shares its embryological origin with the central nervous system, optical coherence tomography (OCT), an imaging technique frequently employed in ophthalmology to analyze the macula and intraretinal layer thicknesses and volumes, has recently become increasingly important in psychiatric research. We examined 34 autistic and 31 neurotypical adults (NT) using OCT. Autistic adults had reduced overall macular and outer nuclear layer (ONL) thickness and volume compared to NT.
View Article and Find Full Text PDFBackground: The German Ophthalmological Society (DOG) regularly records the scientific activities of ophthalmological research institutions in Germany.
Objective: With this publication the DOG wants to make the performance of scientific ophthalmology in Germany transparent and increase the options for future research cooperation with facilities of research institutions.
Methods: Systematic survey of German research centers in ophthalmology.
Orbital tumors comprise a variety of diseases, although tumors of the peripheral nerves are rare. Of these, schwannoma is considered the most common entity, consisting histopathologically almost exclusively of Schwann cells. Another benign tumor containing Schwann cells is ganglioneuroma.
View Article and Find Full Text PDFArticle Synopsis
- - Graves' orbitopathy (GO) causes symptoms like bulging eyes and vision problems due to increased tissue in the eye socket, especially muscle and fat.
- - A study analyzed 83 orbits from 47 patients who underwent surgery and found that those with more muscle had worse preoperative visual acuity (VA) but showed significant improvement post-surgery.
- - The results suggest that surgery, specifically pterional orbital decompression, can effectively enhance vision, especially in patients with increased muscle volume, highlighting the importance of surgical treatment for those with reduced VA.
Purpose: To assess the time course of secondary visual axis opacification (VAO) leading to additional surgery after primary intraocular lens (IOL) implantation in children and to describe further surgical outcomes. Comparison of lens types.
Design: Single-center, retrospective analysis of children aged 1 to 14 years who underwent cataract surgery with primary IOL implantation.
Optic atrophy 1 (MIM #165500) is caused by pathogenic variants in the gene OPA1 (OPA1 MITOCHONDRIAL DYNAMIN-LIKE GTPase, MIM *605290) and is inherited in an autosomal dominant manner. We describe a 6-year-old male patient with severe early onset manifestation of optic atrophy, whose parents are subjectively asymptomatic. OPA1-sequence analysis revealed the heterozygous missense variant NM_015560.
View Article and Find Full Text PDFBackground: To date, only four cases of ocular spiroplasma infection have been reported in the entire ophthalmic literature. We add two more cases to raise awareness of this sight-threatening congenital disease that manifests as cataract with ocular inflammation.
Case Presentation: Both infants were referred for cataracts associated with ocular inflammation.