Study on breast carcinoma Her2/neu and hormonal receptors status assessed by automated images analysis systems: ACIS III (Dako) and ScanScope (Aperio).

Unlabelled: Her-2/neu is overexpressed in 20-30% of breast cancer patients and is associated with a more aggressive disease. Identification of Her-2/c-erbB-2-neu overexpression is based on immunohistochemical [ihc] detection of protein and/or gene amplification in fluorescence in situ hybridization test (FISH). Also Estrogen receptors [ER] and Progesterone receptors [PR] are the prognostic and predictive biomarkers, recently analysed by ihc methods.

Virtual microscopy, data management and image analysis in Aperio ScanScope system.

The histology and the pathology clinical practice undergo a digital revolution. Essential change in laboratory practice - from classical light microscopes, thousands of glass specimens waiting on plates to a virtual microscope and onscreen diagnosis is right now. Currently there are more than 30 different systems for the Virtual Microscopy available on the market.