Publications by authors named "Wojciech Labaj"
Differentiated thyroid cancer (DTC) has one of the lowest cancer mutational burdens, while anaplastic thyroid cancer (ATC) has a much higher mutation frequency. A fraction of ATC has an associated differentiated component, which suggests the coevolution of both cancers. Here, we aimed to compare mutation frequency in coexisting ATC and DTC diagnosed concurrently in the same thyroid gland (3 cases) as well as in archetypal DTC and ATC alone (5 cases each).
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- - Exosomes play a crucial role in cell-to-cell communication, particularly in how cells respond to ionizing radiation, and their function is influenced by the molecules they carry, like proteins and miRNAs.
- - The study compared the miRNA profiles of FaDu cancer cells exposed to high doses of radiation (2 and 8 Gy) and the exosomes they released, revealing significant differences in the abundance of various miRNAs between the cells and the exosomes.
- - Notably, while some miRNAs were downregulated in the irradiated cells, they were found to be upregulated in the exosomes, indicating distinct radiation-induced effects and suggesting a potential role for these exosome-associated miRNAs in the radiation-induced bystander effect
Large collections of data in studies on cancer such as leukaemia provoke the necessity of applying tailored analysis algorithms to ensure supreme information extraction. In this work, a custom-fit pipeline is demonstrated for thorough investigation of the voluminous MILE gene expression data set. Three analyses are accomplished, each for gaining a deeper understanding of the processes underlying leukaemia types and subtypes.
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