Publications by authors named "Woei-Cheang Shyu"
Article Synopsis
- Cancer cells have a high demand for sugars, and researchers developed glycopolymer-like nanoparticles that target specific receptors on cancer-associated macrophages to enhance their effectiveness in fighting tumors.
- These nanoparticles, created through a carbonization process, can alter immune cell polarization and cellular metabolism, promoting a transition from M2 (immunosuppressive) to M1 (pro-inflammatory) macrophages, which helps overcome tumor defenses.
- In models of glioblastoma and pancreatic cancer, these nanoparticles not only induced cancer cell death but also improved the effectiveness of immunotherapy by remodeling the tumor microenvironment, activating immune responses, and facilitating the activity of cytotoxic T lymphocytes and dendritic cells.
This study explores the synergistic impact of Programmed Death Ligand 1 (PD-L1) and Protein Kinase B (Akt) overexpression in adipose-derived mesenchymal stem cells (AdMSCs) for ameliorating cardiac dysfunction after myocardial infarction (MI). Post-MI adult Wistar rats were allocated into four groups: sham, MI, ADMSC treatment, and ADMSCs overexpressed with PD-L1 and Akt (AdMSC-PDL1-Akt) treatment. MI was induced via left anterior descending coronary artery ligation, followed by intramyocardial AdMSC injections.
View Article and Find Full Text PDFBackground: Despite patients with severe coronavirus disease (COVID-19) receiving standard triple therapy, including steroids, antiviral agents, and anticytokine therapy, health condition of certain patients continue to deteriorate. In Taiwan, the COVID-19 mortality has been high since the emergence of previous variants of this disease (such as alpha, beta, or delta). We aimed to evaluate whether adjunctive infusion of human umbilical cord mesenchymal stem cells (MSCs) (hUC-MSCs) on top of dexamethasone, remdesivir, and tocilizumab improves pulmonary oxygenation and suppresses inflammatory cytokines in patients with severe COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- * The study focused on using human olfactory ensheathing cells (hOECs) for intracranial transplantation in a mouse model (ATXN3-84Q) to evaluate potential therapeutic effects.
- * Results showed that the treatment improved motor function, reduced cerebellar inflammation, and supported the survival and maturation of important brain cells, suggesting hOEC transplantation could be a promising new treatment strategy for SCA3.