Lamotrigine serum levels: Ceiling effect in people with epilepsy in remission?

Background: Antiepileptic drug titration in epilepsy remains mostly empirical. Since in practice seizure remission may be obtained with low doses, we aimed to determine whether patients in remission have lower lamotrigine levels than those with ongoing seizures.

Methods: Retrospective comparison of the distribution of lamotrigine levels among unselected patients in remission and with ongoing seizures.